{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:29:48Z","timestamp":1791221388038,"version":"4.1.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>There are few sex-specific outcome data in heart failure with preserved ejection fraction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We assessed sex differences in baseline characteristics and outcomes among 4128 patients with heart failure with preserved ejection fraction in the Irbesartan in Heart Failure with Preserved Ejection Fraction (I-PRESERVE) trial. Women (n=2491) with heart failure with preserved ejection fraction were \u22481 year older (72\u00b17 years versus 71\u00b17 years) and more likely to be obese (46% versus 35%) and have chronic kidney disease (34% versus 26%) and hypertension (91% versus 85%) than men but less likely to have an ischemic cause (19% versus 34%), atrial fibrillation (27% versus 33%), or chronic obstructive pulmonary disease (8% versus 13%) (all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). During a mean of 49.5 months, there were 881 deaths (447 in women, 434 in men; risk ratio, 0.64; 95% CI, 0.56\u20130.74) and 5776 hospitalizations (3239 in women, 2537 in men; risk ratio, 0.80; 95% CI, 0.76\u20130.84). Women had lower risk of all-cause events (deaths and hospitalizations), even after adjusting for baseline characteristics (adjusted hazards ratio, 0.81; 95% CI, 0.73\u20130.89). However, the sex-related difference in risk of all-cause events was modified in the presence or absence of atrial fibrillation, renal dysfunction, stable angina pectoris, or advanced New York Heart Association class symptoms.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In patients with typical heart failure with preserved ejection fraction, there were prominent sex differences in baseline characteristics and outcomes. Women had better overall prognosis, although the presence of 4 common baseline characteristics seemed to moderate this finding.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT000095238.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.112.970061","type":"journal-article","created":{"date-parts":[[2012,8,12]],"date-time":"2012-08-12T02:14:19Z","timestamp":1344737659000},"page":"571-578","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":203,"title":["Sex Differences in Clinical Characteristics and Outcomes in Elderly Patients With Heart Failure and Preserved Ejection Fraction"],"prefix":"10.1161","volume":"5","author":[{"given":"Carolyn S.P.","family":"Lam","sequence":"first","affiliation":[{"name":"From the National University Health System, Singapore (C.S.P.L.); Georgetown University and Washington DC Veterans Affairs Medical Center, Washington, DC (P.E.C.); Department of Veterans Affairs Health Care System and Department of Medicine, University of Minnesota, Minneapolis, MN (I.S.A., T.S.R., M.K.); Universit\u00e9 Paris 6 and Hospital Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France (M.K.); British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Carson","sequence":"additional","affiliation":[{"name":"From the National University Health System, Singapore (C.S.P.L.); Georgetown University and Washington DC Veterans Affairs Medical Center, Washington, DC (P.E.C.); Department of Veterans Affairs Health Care System and Department of Medicine, University of Minnesota, Minneapolis, MN (I.S.A., T.S.R., M.K.); Universit\u00e9 Paris 6 and Hospital Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France (M.K.); British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inder S.","family":"Anand","sequence":"additional","affiliation":[{"name":"From the National University Health System, Singapore (C.S.P.L.); Georgetown University and Washington DC Veterans Affairs Medical Center, Washington, DC (P.E.C.); Department of Veterans Affairs Health Care System and Department of Medicine, University of Minnesota, Minneapolis, MN (I.S.A., T.S.R., M.K.); Universit\u00e9 Paris 6 and Hospital Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France (M.K.); British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Rector","sequence":"additional","affiliation":[{"name":"From the National University Health System, Singapore (C.S.P.L.); Georgetown University and Washington DC Veterans Affairs Medical Center, Washington, DC (P.E.C.); Department of Veterans Affairs Health Care System and Department of Medicine, University of Minnesota, Minneapolis, MN (I.S.A., T.S.R., M.K.); Universit\u00e9 Paris 6 and Hospital Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France (M.K.); British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kuskowski","sequence":"additional","affiliation":[{"name":"From the National University Health System, Singapore (C.S.P.L.); Georgetown University and Washington DC Veterans Affairs Medical Center, Washington, DC (P.E.C.); Department of Veterans Affairs Health Care System and Department of Medicine, University of Minnesota, Minneapolis, MN (I.S.A., T.S.R., M.K.); Universit\u00e9 Paris 6 and Hospital Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France (M.K.); British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Komajda","sequence":"additional","affiliation":[{"name":"From the National University Health System, Singapore (C.S.P.L.); Georgetown University and Washington DC Veterans Affairs Medical Center, Washington, DC (P.E.C.); Department of Veterans Affairs Health Care System and Department of Medicine, University of Minnesota, Minneapolis, MN (I.S.A., T.S.R., M.K.); Universit\u00e9 Paris 6 and Hospital Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France (M.K.); British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"McKelvie","sequence":"additional","affiliation":[{"name":"From the National University Health System, Singapore (C.S.P.L.); Georgetown University and Washington DC Veterans Affairs Medical Center, Washington, DC (P.E.C.); Department of Veterans Affairs Health Care System and Department of Medicine, University of Minnesota, Minneapolis, MN (I.S.A., T.S.R., M.K.); Universit\u00e9 Paris 6 and Hospital Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France (M.K.); British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"McMurray","sequence":"additional","affiliation":[{"name":"From the National University Health System, Singapore (C.S.P.L.); Georgetown University and Washington DC Veterans Affairs Medical Center, Washington, DC (P.E.C.); Department of Veterans Affairs Health Care System and Department of Medicine, University of Minnesota, Minneapolis, MN (I.S.A., T.S.R., M.K.); Universit\u00e9 Paris 6 and Hospital Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France (M.K.); British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Zile","sequence":"additional","affiliation":[{"name":"From the National University Health System, Singapore (C.S.P.L.); Georgetown University and Washington DC Veterans Affairs Medical Center, Washington, DC (P.E.C.); Department of Veterans Affairs Health Care System and Department of Medicine, University of Minnesota, Minneapolis, MN (I.S.A., T.S.R., M.K.); Universit\u00e9 Paris 6 and Hospital Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France (M.K.); British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry M.","family":"Massie","sequence":"additional","affiliation":[{"name":"From the National University Health System, Singapore (C.S.P.L.); Georgetown University and Washington DC Veterans Affairs Medical Center, Washington, DC (P.E.C.); Department of Veterans Affairs Health Care System and Department of Medicine, University of Minnesota, Minneapolis, MN (I.S.A., T.S.R., M.K.); Universit\u00e9 Paris 6 and Hospital Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France (M.K.); British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalane W.","family":"Kitzman","sequence":"additional","affiliation":[{"name":"From the National University Health System, Singapore (C.S.P.L.); Georgetown University and Washington DC Veterans Affairs Medical Center, Washington, DC (P.E.C.); Department of Veterans Affairs Health Care System and Department of Medicine, University of Minnesota, Minneapolis, MN (I.S.A., T.S.R., M.K.); Universit\u00e9 Paris 6 and Hospital Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France (M.K.); British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.M.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01393-X"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00118-7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01165-6"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1997.129150000.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02696-7"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2005.09.005"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2007.12.012"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.11.042"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.3.344"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020265"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.770602"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.09.032"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.17.2334"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.628347"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14285-7"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl250"},{"key":"e_1_3_3_18_2","first-page":"1257","article-title":"Irbesartan for heart failure with preserved ejection fraction.","volume":"360","author":"Tomoda H","year":"2009","unstructured":"Tomoda H. 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