{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T22:59:24Z","timestamp":1773097164449,"version":"3.50.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Renal dysfunction is an important prognostic factor in heart failure (HF), but whether this dysfunction progresses to end-stage renal disease (ESRD) is unknown. Therefore, we examined incidence and predictors of ESRD in outpatients with HF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Patients with systolic HF were identified in The Danish Heart Failure database and new-onset ESRD from the Danish Registry on Dialysis. Renal function was estimated by The Chronic Kidney Disease Epidemiology Collaboration equation and patients grouped by estimated glomerular filtration rate (eGFR)\u2014group I: \u226560 mL\/min per 1.73 m\n              <jats:sup>2<\/jats:sup>\n              , group II: 30 to 59 mL\/min per 1.73 m\n              <jats:sup>2<\/jats:sup>\n              , group III: 15 to 29 mL\/min per 1.73 m\n              <jats:sup>2<\/jats:sup>\n              , group IV: &lt;15 mL\/min per 1.73 m\n              <jats:sup>2<\/jats:sup>\n              . Cox hazard models for time to ESRD, to death, and the composite end point of ESRD or death were constructed and predictors of ESRD identified. A total of 8204 patients were included in the analyses. Median age was 70 years (Q, 61\u201377), 28% were women, median left ventricular ejection fraction was 30% (Q, 24\u201340), and median eGFR was 68 (Q, 51\u201385) mL\/min per 1.73 m\n              <jats:sup>2<\/jats:sup>\n              . Forty-one patients developed ESRD (1.3\/1000 patient-years). Baseline eGFR group II (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), eGFR group III (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), eGFR group IV (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), uncontrolled hypertension (\n              <jats:italic>P<\/jats:italic>\n              =0.049), need of diuretics, and age &lt;60 years (\n              <jats:italic>P<\/jats:italic>\n              =0.016) were associated with time to ESRD.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              ESRD is rare in outpatients with systolic HF and is mainly observed in patients with an eGFR &lt;30 mL\/min per 1.73 m\n              <jats:sup>2<\/jats:sup>\n              . A low eGFR, age &lt;60 years, need of diuretics, and uncontrolled hypertension identify patients with an increased risk for ESRD.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.113.000553","type":"journal-article","created":{"date-parts":[[2013,10,19]],"date-time":"2013-10-19T01:53:30Z","timestamp":1382147610000},"page":"1124-1131","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Incidence and Predictors of End-Stage Renal Disease in Outpatients With Systolic Heart Failure"],"prefix":"10.1161","volume":"6","author":[{"given":"Helle","family":"Bosselmann","sequence":"first","affiliation":[{"name":"From the Departments of Cardio-, Nephro-, and Endocrinology, North Zealand Hospital, University of Copenhagen, Hillerod, Denmark (H.B., N.T., M.S.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (G.G., C.T.-P., S.C.); Department of Cardiology (F.G., L.K., K.R.), and Department of Nephrology (A.-L.K.), Rigshospitalet, Copenhagen, Denmark; Department of Internal Medicine, Frederiksberg University Hospital, Copenhagen, Denmark (P.R.H.); Department of Cardiology, Odense..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Gislason","sequence":"additional","affiliation":[{"name":"From the Departments of Cardio-, Nephro-, and Endocrinology, North Zealand Hospital, University of Copenhagen, Hillerod, Denmark (H.B., N.T., M.S.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (G.G., C.T.-P., S.C.); Department of Cardiology (F.G., L.K., K.R.), and Department of Nephrology (A.-L.K.), Rigshospitalet, Copenhagen, Denmark; Department of Internal Medicine, Frederiksberg University Hospital, Copenhagen, Denmark (P.R.H.); Department of Cardiology, Odense..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Finn","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"From the Departments of Cardio-, Nephro-, and Endocrinology, North Zealand Hospital, University of Copenhagen, Hillerod, Denmark (H.B., N.T., M.S.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (G.G., C.T.-P., S.C.); Department of Cardiology (F.G., L.K., K.R.), and Department of Nephrology (A.-L.K.), Rigshospitalet, Copenhagen, Denmark; Department of Internal Medicine, Frederiksberg University Hospital, Copenhagen, Denmark (P.R.H.); Department of Cardiology, Odense..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per R.","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"From the Departments of Cardio-, Nephro-, and Endocrinology, North Zealand Hospital, University of Copenhagen, Hillerod, Denmark (H.B., N.T., M.S.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (G.G., C.T.-P., S.C.); Department of Cardiology (F.G., L.K., K.R.), and Department of Nephrology (A.-L.K.), Rigshospitalet, Copenhagen, Denmark; Department of Internal Medicine, Frederiksberg University Hospital, Copenhagen, Denmark (P.R.H.); Department of Cardiology, Odense..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Videbaek","sequence":"additional","affiliation":[{"name":"From the Departments of Cardio-, Nephro-, and Endocrinology, North Zealand Hospital, University of Copenhagen, Hillerod, Denmark (H.B., N.T., M.S.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (G.G., C.T.-P., S.C.); Department of Cardiology (F.G., L.K., K.R.), and Department of Nephrology (A.-L.K.), Rigshospitalet, Copenhagen, Denmark; Department of Internal Medicine, Frederiksberg University Hospital, Copenhagen, Denmark (P.R.H.); Department of Cardiology, Odense..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Kober","sequence":"additional","affiliation":[{"name":"From the Departments of Cardio-, Nephro-, and Endocrinology, North Zealand Hospital, University of Copenhagen, Hillerod, Denmark (H.B., N.T., M.S.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (G.G., C.T.-P., S.C.); Department of Cardiology (F.G., L.K., K.R.), and Department of Nephrology (A.-L.K.), Rigshospitalet, Copenhagen, Denmark; Department of Internal Medicine, Frederiksberg University Hospital, Copenhagen, Denmark (P.R.H.); Department of Cardiology, Odense..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Torp-Pedersen","sequence":"additional","affiliation":[{"name":"From the Departments of Cardio-, Nephro-, and Endocrinology, North Zealand Hospital, University of Copenhagen, Hillerod, Denmark (H.B., N.T., M.S.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (G.G., C.T.-P., S.C.); Department of Cardiology (F.G., L.K., K.R.), and Department of Nephrology (A.-L.K.), Rigshospitalet, Copenhagen, Denmark; Department of Internal Medicine, Frederiksberg University Hospital, Copenhagen, Denmark (P.R.H.); Department of Cardiology, Odense..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Tonder","sequence":"additional","affiliation":[{"name":"From the Departments of Cardio-, Nephro-, and Endocrinology, North Zealand Hospital, University of Copenhagen, Hillerod, Denmark (H.B., N.T., M.S.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (G.G., C.T.-P., S.C.); Department of Cardiology (F.G., L.K., K.R.), and Department of Nephrology (A.-L.K.), Rigshospitalet, Copenhagen, Denmark; Department of Internal Medicine, Frederiksberg University Hospital, Copenhagen, Denmark (P.R.H.); Department of Cardiology, Odense..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasper","family":"Rossing","sequence":"additional","affiliation":[{"name":"From the Departments of Cardio-, Nephro-, and Endocrinology, North Zealand Hospital, University of Copenhagen, Hillerod, Denmark (H.B., N.T., M.S.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (G.G., C.T.-P., S.C.); Department of Cardiology (F.G., L.K., K.R.), and Department of Nephrology (A.-L.K.), Rigshospitalet, Copenhagen, Denmark; Department of Internal Medicine, Frederiksberg University Hospital, Copenhagen, Denmark (P.R.H.); Department of Cardiology, Odense..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Christensen","sequence":"additional","affiliation":[{"name":"From the Departments of Cardio-, Nephro-, and Endocrinology, North Zealand Hospital, University of Copenhagen, Hillerod, Denmark (H.B., N.T., M.S.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (G.G., C.T.-P., S.C.); Department of Cardiology (F.G., L.K., K.R.), and Department of Nephrology (A.-L.K.), Rigshospitalet, Copenhagen, Denmark; Department of Internal Medicine, Frederiksberg University Hospital, Copenhagen, Denmark (P.R.H.); Department of Cardiology, Odense..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Lise","family":"Kamper","sequence":"additional","affiliation":[{"name":"From the Departments of Cardio-, Nephro-, and Endocrinology, North Zealand Hospital, University of Copenhagen, Hillerod, Denmark (H.B., N.T., M.S.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (G.G., C.T.-P., S.C.); Department of Cardiology (F.G., L.K., K.R.), and Department of Nephrology (A.-L.K.), Rigshospitalet, Copenhagen, Denmark; Department of Internal Medicine, Frederiksberg University Hospital, Copenhagen, Denmark (P.R.H.); Department of Cardiology, Odense..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Heaf","sequence":"additional","affiliation":[{"name":"From the Departments of Cardio-, Nephro-, and Endocrinology, North Zealand Hospital, University of Copenhagen, Hillerod, Denmark (H.B., N.T., M.S.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (G.G., C.T.-P., S.C.); Department of Cardiology (F.G., L.K., K.R.), and Department of Nephrology (A.-L.K.), Rigshospitalet, Copenhagen, Denmark; Department of Internal Medicine, Frederiksberg University Hospital, Copenhagen, Denmark (P.R.H.); Department of Cardiology, Odense..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Schou","sequence":"additional","affiliation":[{"name":"From the Departments of Cardio-, Nephro-, and Endocrinology, North Zealand Hospital, University of Copenhagen, Hillerod, Denmark (H.B., N.T., M.S.); Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark (G.G., C.T.-P., S.C.); Department of Cardiology (F.G., L.K., K.R.), and Department of Nephrology (A.-L.K.), Rigshospitalet, Copenhagen, Denmark; Department of Internal Medicine, Frederiksberg University Hospital, Copenhagen, Denmark (P.R.H.); Department of Cardiology, Odense..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp108"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2007.04.008"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005030270"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr190"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61469-0"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2012.04.009"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi696"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.02.098"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circheartfailure.111.963256"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006010063"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.111.028282"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.048"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.963066"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/circheartfailure.110.959882"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.123841"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp571"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811409654"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_3_4_20_2","first-page":"S1","article-title":"K\/doqi clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification.","volume":"39","author":"National Kidney Foundation","year":"2002","unstructured":"National Kidney Foundation. 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