{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T10:10:16Z","timestamp":1769940616336,"version":"3.49.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Heart failure (HF) progression results in worsening functional capacity and end-organ compromise. HF may occur acutely or be associated with a chronic presentation. We hypothesized that the duration of HF affects outcomes after mechanical circulatory support.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              A total of 10 730 patients registered in Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) who received primary implant of a mechanical circulatory support device were stratified according to the duration of HF symptoms: acute HF (AHF; \u22641 month), sub-AHF (1\u201312 months), and chronic HF (Cr-HF; \u2265 12 months). AHF patients were younger with a higher proportion of women and white and with a lower prevalence of peripheral vascular disease and history of prior cardiac surgeries. Sixty percent of AHF patients were INTERMACS profile 1 at the time of implantation versus 24% and 13.2% in the sub-AHF and Cr-HF groups, respectively (\n              <jats:italic>P<\/jats:italic>\n              =0.0001). Patients with AHF had the highest utilization of biventricular support (14.4%). The estimated survival at 4 years was 58%, 51%, and 45% for the AHF, sub-AHF, and Cr-HF patients (\n              <jats:italic>P<\/jats:italic>\n              =0.006). The proportion of patients with AHF who received heart transplantation at 1 year was 29% compared with 22.6% in the patients with Cr-HF. After adjustment for known risk factors of adverse outcome, patients with AHF have a better late phase prognosis compared with patients with Cr-HF (hazard ratio, 0.34;\n              <jats:italic>P<\/jats:italic>\n              =0.0003).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>The duration of HF before durable mechanical circulatory support implant is an important variable influencing outcome. Patients with AHF had improved survival at 4 years and higher rates of transplantation at 1 year despite higher acuity of presentation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.115.002321","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T02:19:49Z","timestamp":1438913989000},"page":"953-959","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Duration of Heart Failure Is an Important Predictor of Outcomes After Mechanical Circulatory Support"],"prefix":"10.1161","volume":"8","author":[{"given":"Renzo Y.","family":"Loyaga-Rendon","sequence":"first","affiliation":[{"name":"From the Division of Cardiovascular Diseases, Department of Medicine (R.Y.L.-R., D.A., S.V.P., J.A.T.), Division of Cardiothoracic Surgery, Department of Surgery (R.C.), and Department of Epidemiology, School of Public Health (R.C.), and Division of Cardiothoracic Surgery (D.N., J.K.), University of Alabama at Birmingham; and Section of Heart Failure, Department of Medicine, Cleveland Clinic Foundation, OH (R.C.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Acharya","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases, Department of Medicine (R.Y.L.-R., D.A., S.V.P., J.A.T.), Division of Cardiothoracic Surgery, Department of Surgery (R.C.), and Department of Epidemiology, School of Public Health (R.C.), and Division of Cardiothoracic Surgery (D.N., J.K.), University of Alabama at Birmingham; and Section of Heart Failure, Department of Medicine, Cleveland Clinic Foundation, OH (R.C.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salpy V.","family":"Pamboukian","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases, Department of Medicine (R.Y.L.-R., D.A., S.V.P., J.A.T.), Division of Cardiothoracic Surgery, Department of Surgery (R.C.), and Department of Epidemiology, School of Public Health (R.C.), and Division of Cardiothoracic Surgery (D.N., J.K.), University of Alabama at Birmingham; and Section of Heart Failure, Department of Medicine, Cleveland Clinic Foundation, OH (R.C.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose A.","family":"Tallaj","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases, Department of Medicine (R.Y.L.-R., D.A., S.V.P., J.A.T.), Division of Cardiothoracic Surgery, Department of Surgery (R.C.), and Department of Epidemiology, School of Public Health (R.C.), and Division of Cardiothoracic Surgery (D.N., J.K.), University of Alabama at Birmingham; and Section of Heart Failure, Department of Medicine, Cleveland Clinic Foundation, OH (R.C.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Cantor","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases, Department of Medicine (R.Y.L.-R., D.A., S.V.P., J.A.T.), Division of Cardiothoracic Surgery, Department of Surgery (R.C.), and Department of Epidemiology, School of Public Health (R.C.), and Division of Cardiothoracic Surgery (D.N., J.K.), University of Alabama at Birmingham; and Section of Heart Failure, Department of Medicine, Cleveland Clinic Foundation, OH (R.C.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall C.","family":"Starling","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases, Department of Medicine (R.Y.L.-R., D.A., S.V.P., J.A.T.), Division of Cardiothoracic Surgery, Department of Surgery (R.C.), and Department of Epidemiology, School of Public Health (R.C.), and Division of Cardiothoracic Surgery (D.N., J.K.), University of Alabama at Birmingham; and Section of Heart Failure, Department of Medicine, Cleveland Clinic Foundation, OH (R.C.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Naftel","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases, Department of Medicine (R.Y.L.-R., D.A., S.V.P., J.A.T.), Division of Cardiothoracic Surgery, Department of Surgery (R.C.), and Department of Epidemiology, School of Public Health (R.C.), and Division of Cardiothoracic Surgery (D.N., J.K.), University of Alabama at Birmingham; and Section of Heart Failure, Department of Medicine, Cleveland Clinic Foundation, OH (R.C.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James K.","family":"Kirklin","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Diseases, Department of Medicine (R.Y.L.-R., D.A., S.V.P., J.A.T.), Division of Cardiothoracic Surgery, Department of Surgery (R.C.), and Department of Epidemiology, School of Public Health (R.C.), and Division of Cardiothoracic Surgery (D.N., J.K.), University of Alabama at Birmingham; and Section of Heart Failure, Department of Medicine, Cleveland Clinic Foundation, OH (R.C.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.019"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-012-9306-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2011.02573.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.74.Suppl_1.S132"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs381"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302807"},{"key":"e_1_3_3_8_2","first-page":"713","article-title":"Predicting outcome after listing for heart transplantation in children: comparison of Kaplan-Meier and parametric competing risk analysis. Pediatric Heart Transplant Study Group.","volume":"16","author":"McGiffin DC","year":"1997","unstructured":"McGiffin DC, Naftel DC, Kirklin JK, Morrow WR, Towbin J, Shaddy R, Alejos J, Rossi A. Predicting outcome after listing for heart transplantation in children: comparison of Kaplan-Meier and parametric competing risk analysis. Pediatric Heart Transplant Study Group. J Heart Lung Transplant. 1997;16:713\u2013722.","journal-title":"J Heart Lung Transplant"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1986.10478314"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.04.010"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-012-9836-3"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.09.001"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.02.027"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.06.023"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.12.014"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.06.009"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.04.010"},{"key":"e_1_3_3_18_2","first-page":"854","article-title":"Mechanical circulatory support in acute heart failure.","volume":"39","author":"Gregoric ID.","year":"2012","unstructured":"Gregoric ID. Mechanical circulatory support in acute heart failure. Tex Heart Inst J. 2012;39:854\u2013855.","journal-title":"Tex Heart Inst J"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.113.000721"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.05.033"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2012.01.020"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003093421003"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.02.015"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.12.004"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp549"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2012.08.001"}],"container-title":["Circulation: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCHEARTFAILURE.115.002321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:49:11Z","timestamp":1715564951000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCHEARTFAILURE.115.002321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1161\/CIRCHEARTFAILURE.115.002321"],"URL":"https:\/\/doi.org\/10.1161\/circheartfailure.115.002321","relation":{},"ISSN":["1941-3289","1941-3297"],"issn-type":[{"value":"1941-3289","type":"print"},{"value":"1941-3297","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"2015-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}