{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:12:16Z","timestamp":1775074336171,"version":"3.50.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Atrial fibrillation is common in patients with heart failure, but outcomes of patients with both conditions who receive cardiac resynchronization therapy with defibrillator (CRT-D) compared with an implantable cardioverter-defibrillator (ICD) alone are unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>Using the National Cardiovascular Data Registry\u2019s ICD Registry linked with Medicare claims, we identified 8951 patients with atrial fibrillation who were eligible for CRT-D and underwent first-time device implantation for primary prevention between April 2006 and December 2009. We used Cox proportional hazards models and inverse probability-weighted estimates to compare outcomes with CRT-D versus ICD alone. Cumulative incidence of mortality (744 [33%] for ICD; 1893 [32%] for CRT-D) and readmission (1788 [76%] for ICD; 4611 [76%] for CRT-D) within 3 years and complications within 90 days were similar between groups. After inverse weighting for the probability of receiving CRT-D, risks of mortality (hazard ratio, 0.83; 95% confidence interval, 0.75\u20130.92), all-cause readmission (hazard ratio, 0.86; 95% confidence interval, 0.80\u20130.92), and heart failure readmission (hazard ratio, 0.68; 95% confidence interval, 0.62\u20130.76) were lower with CRT-D compared with ICD alone. There was no significant difference in the 90-day complication rate (hazard ratio, 0.88; 95% confidence interval, 0.60\u20131.29). We observed hospital-level variation in the use of CRT-D among patients with atrial fibrillation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Among eligible patients with heart failure and atrial fibrillation, CRT-D was associated with lower risks of mortality, all-cause readmission, and heart failure readmission, as well as with a similar risk of complications compared with ICD alone.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.115.002324","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T03:09:20Z","timestamp":1465873760000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Comparative Effectiveness of Cardiac Resynchronization Therapy Among Patients With Heart Failure and Atrial Fibrillation"],"prefix":"10.1161","volume":"9","author":[{"given":"Prateeti","family":"Khazanie","sequence":"first","affiliation":[{"name":"From the Duke Clinical Research Institute (P.K., M.A.G., S.M.A.-K., J.P.P., L.H.C., A.F.H.) and Department of Medicine (P.K., S.M.A.-K., J.P.P., L.H.C., A.F.H.), Duke University School of Medicine, Durham, NC; Veterans Affairs Eastern Colorado Healthcare System, Denver, CO (P.D.V.); University of Colorado Anschutz Medical Campus, Aurora, CO (F.A.M.); and Veterans Affairs Palo Alto Health Care System, Palo Alto, CA and Stanford University School of Medicine, CA (M.P.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa A.","family":"Greiner","sequence":"additional","affiliation":[{"name":"From the Duke Clinical Research Institute (P.K., M.A.G., S.M.A.-K., J.P.P., L.H.C., A.F.H.) and Department of Medicine (P.K., S.M.A.-K., J.P.P., L.H.C., A.F.H.), Duke University School of Medicine, Durham, NC; Veterans Affairs Eastern Colorado Healthcare System, Denver, CO (P.D.V.); University of Colorado Anschutz Medical Campus, Aurora, CO (F.A.M.); and Veterans Affairs Palo Alto Health Care System, Palo Alto, CA and Stanford University School of Medicine, CA (M.P.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana M.","family":"Al-Khatib","sequence":"additional","affiliation":[{"name":"From the Duke Clinical Research Institute (P.K., M.A.G., S.M.A.-K., J.P.P., L.H.C., A.F.H.) and Department of Medicine (P.K., S.M.A.-K., J.P.P., L.H.C., A.F.H.), Duke University School of Medicine, Durham, NC; Veterans Affairs Eastern Colorado Healthcare System, Denver, CO (P.D.V.); University of Colorado Anschutz Medical Campus, Aurora, CO (F.A.M.); and Veterans Affairs Palo Alto Health Care System, Palo Alto, CA and Stanford University School of Medicine, CA (M.P.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan P.","family":"Piccini","sequence":"additional","affiliation":[{"name":"From the Duke Clinical Research Institute (P.K., M.A.G., S.M.A.-K., J.P.P., L.H.C., A.F.H.) and Department of Medicine (P.K., S.M.A.-K., J.P.P., L.H.C., A.F.H.), Duke University School of Medicine, Durham, NC; Veterans Affairs Eastern Colorado Healthcare System, Denver, CO (P.D.V.); University of Colorado Anschutz Medical Campus, Aurora, CO (F.A.M.); and Veterans Affairs Palo Alto Health Care System, Palo Alto, CA and Stanford University School of Medicine, CA (M.P.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mintu P.","family":"Turakhia","sequence":"additional","affiliation":[{"name":"From the Duke Clinical Research Institute (P.K., M.A.G., S.M.A.-K., J.P.P., L.H.C., A.F.H.) and Department of Medicine (P.K., S.M.A.-K., J.P.P., L.H.C., A.F.H.), Duke University School of Medicine, Durham, NC; Veterans Affairs Eastern Colorado Healthcare System, Denver, CO (P.D.V.); University of Colorado Anschutz Medical Campus, Aurora, CO (F.A.M.); and Veterans Affairs Palo Alto Health Care System, Palo Alto, CA and Stanford University School of Medicine, CA (M.P.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D.","family":"Varosy","sequence":"additional","affiliation":[{"name":"From the Duke Clinical Research Institute (P.K., M.A.G., S.M.A.-K., J.P.P., L.H.C., A.F.H.) and Department of Medicine (P.K., S.M.A.-K., J.P.P., L.H.C., A.F.H.), Duke University School of Medicine, Durham, NC; Veterans Affairs Eastern Colorado Healthcare System, Denver, CO (P.D.V.); University of Colorado Anschutz Medical Campus, Aurora, CO (F.A.M.); and Veterans Affairs Palo Alto Health Care System, Palo Alto, CA and Stanford University School of Medicine, CA (M.P.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick A.","family":"Masoudi","sequence":"additional","affiliation":[{"name":"From the Duke Clinical Research Institute (P.K., M.A.G., S.M.A.-K., J.P.P., L.H.C., A.F.H.) and Department of Medicine (P.K., S.M.A.-K., J.P.P., L.H.C., A.F.H.), Duke University School of Medicine, Durham, NC; Veterans Affairs Eastern Colorado Healthcare System, Denver, CO (P.D.V.); University of Colorado Anschutz Medical Campus, Aurora, CO (F.A.M.); and Veterans Affairs Palo Alto Health Care System, Palo Alto, CA and Stanford University School of Medicine, CA (M.P.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley H.","family":"Curtis","sequence":"additional","affiliation":[{"name":"From the Duke Clinical Research Institute (P.K., M.A.G., S.M.A.-K., J.P.P., L.H.C., A.F.H.) and Department of Medicine (P.K., S.M.A.-K., J.P.P., L.H.C., A.F.H.), Duke University School of Medicine, Durham, NC; Veterans Affairs Eastern Colorado Healthcare System, Denver, CO (P.D.V.); University of Colorado Anschutz Medical Campus, Aurora, CO (F.A.M.); and Veterans Affairs Palo Alto Health Care System, Palo Alto, CA and Stanford University School of Medicine, CA (M.P.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian F.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"From the Duke Clinical Research Institute (P.K., M.A.G., S.M.A.-K., J.P.P., L.H.C., A.F.H.) and Department of Medicine (P.K., S.M.A.-K., J.P.P., L.H.C., A.F.H.), Duke University School of Medicine, Durham, NC; 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