{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:10:01Z","timestamp":1790745001697,"version":"4.1.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) profiles provide important prognostic information for patients with advanced heart failure (HF) receiving mechanical support. The value of INTERMACS profiling has not been shown for patients followed on medical therapy for advanced HF at centers that also offer mechanical circulatory support.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>This prospective, observational study enrolled 166 patients with chronic New York Heart Association class III\u2013IV HF, ejection fraction \u226430%, and \u22651 HF hospitalization in the previous year, excluding patients listed for transplant or receiving chronic intravenous inotropic therapy. Subjects were followed for at least 12 months or until death, mechanical support, or transplant. Baseline features, quality of life, and outcomes were compared according to INTERMACS profile. Mean age was 57 years, ejection fraction 18%, and 57% had HF &gt;5 years, whereas 23% of subjects were INTERMACS profile 4, 32% profile 5, and 45% profile 6\/7. At 1 year, only 47% of this ambulatory advanced HF cohort remained alive on medical therapy. Patients in INTERMACS profile 4 were more likely to die or require mechanical support, with only 52% of these patients alive without support after the first 6 months. Profile 6\/7 patients had 1-year survival of 84%, similar to outcomes for contemporary destination left ventricular assist device recipients. Quality of life using the indexed EuroQol score was poor across profiles 4 to 7, although severe limitation was less common than for ambulatory patients enrolled in INTERMACS before ventricular assist device implantation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Ambulatory patients with systolic HF, a heavy symptom burden, and at least 1 recent HF hospitalization are at high risk for death or left ventricular assist device rescue. INTERMACS profiles help identify ambulatory patients with advanced HF who may benefit from current mechanical support devices under existing indications.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.116.003032","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T14:11:33Z","timestamp":1478787093000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":74,"title":["INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) Profiling Identifies Ambulatory Patients at High Risk on Medical Therapy After Hospitalizations for Heart Failure"],"prefix":"10.1161","volume":"9","author":[{"given":"Garrick C.","family":"Stewart","sequence":"first","affiliation":[{"name":"From the Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (G.C.S., L.W.S.); Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (M.M.K.); Department of Medicine, University of Texas Southwestern, Dallas, (P.C.P.); Department of Medicine, University of Michigan, Ann Arbor (J.A.C.); Department of Medicine, Division of Cardiology Duke University, Durham, NC (C.B.P.); Department of Cardiovascular Medicine, Cleveland Clinic..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Kittleson","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (G.C.S., L.W.S.); Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (M.M.K.); Department of Medicine, University of Texas Southwestern, Dallas, (P.C.P.); Department of Medicine, University of Michigan, Ann Arbor (J.A.C.); Department of Medicine, Division of Cardiology Duke University, Durham, NC (C.B.P.); Department of Cardiovascular Medicine, Cleveland Clinic..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parag C.","family":"Patel","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (G.C.S., L.W.S.); Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (M.M.K.); Department of Medicine, University of Texas Southwestern, Dallas, (P.C.P.); Department of Medicine, University of Michigan, Ann Arbor (J.A.C.); Department of Medicine, Division of Cardiology Duke University, Durham, NC (C.B.P.); Department of Cardiovascular Medicine, Cleveland Clinic..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Cowger","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (G.C.S., L.W.S.); Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (M.M.K.); Department of Medicine, University of Texas Southwestern, Dallas, (P.C.P.); Department of Medicine, University of Michigan, Ann Arbor (J.A.C.); Department of Medicine, Division of Cardiology Duke University, Durham, NC (C.B.P.); Department of Cardiovascular Medicine, Cleveland Clinic..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan B.","family":"Patel","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (G.C.S., L.W.S.); Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (M.M.K.); Department of Medicine, University of Texas Southwestern, Dallas, (P.C.P.); Department of Medicine, University of Michigan, Ann Arbor (J.A.C.); Department of Medicine, Division of Cardiology Duke University, Durham, NC (C.B.P.); Department of Cardiovascular Medicine, Cleveland Clinic..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M.","family":"Mountis","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (G.C.S., L.W.S.); Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (M.M.K.); Department of Medicine, University of Texas Southwestern, Dallas, (P.C.P.); Department of Medicine, University of Michigan, Ann Arbor (J.A.C.); Department of Medicine, Division of Cardiology Duke University, Durham, NC (C.B.P.); Department of Cardiovascular Medicine, Cleveland Clinic..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances L.","family":"Johnson","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (G.C.S., L.W.S.); Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (M.M.K.); Department of Medicine, University of Texas Southwestern, Dallas, (P.C.P.); Department of Medicine, University of Michigan, Ann Arbor (J.A.C.); Department of Medicine, Division of Cardiology Duke University, Durham, NC (C.B.P.); Department of Cardiovascular Medicine, Cleveland Clinic..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya E.","family":"Guglin","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (G.C.S., L.W.S.); Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (M.M.K.); Department of Medicine, University of Texas Southwestern, Dallas, (P.C.P.); Department of Medicine, University of Michigan, Ann Arbor (J.A.C.); Department of Medicine, Division of Cardiology Duke University, Durham, NC (C.B.P.); Department of Cardiovascular Medicine, Cleveland Clinic..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Eduardo","family":"Rame","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (G.C.S., L.W.S.); Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (M.M.K.); Department of Medicine, University of Texas Southwestern, Dallas, (P.C.P.); Department of Medicine, University of Michigan, Ann Arbor (J.A.C.); Department of Medicine, Division of Cardiology Duke University, Durham, NC (C.B.P.); Department of Cardiovascular Medicine, Cleveland Clinic..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Teuteberg","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (G.C.S., L.W.S.); Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (M.M.K.); Department of Medicine, University of Texas Southwestern, Dallas, (P.C.P.); Department of Medicine, University of Michigan, Ann Arbor (J.A.C.); Department of Medicine, Division of Cardiology Duke University, Durham, NC (C.B.P.); Department of Cardiovascular Medicine, Cleveland Clinic..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne W.","family":"Stevenson","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (G.C.S., L.W.S.); Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (M.M.K.); Department of Medicine, University of Texas Southwestern, Dallas, (P.C.P.); Department of Medicine, University of Michigan, Ann Arbor (J.A.C.); Department of Medicine, Division of Cardiology Duke University, Durham, NC (C.B.P.); Department of Cardiovascular Medicine, Cleveland Clinic..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.04.010"},{"key":"e_1_3_3_3_2","unstructured":"UAB School of Medicine. 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