{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:08:47Z","timestamp":1790042927675,"version":"4.0.1"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>In the conventional paradigm of the progression of left ventricular hypertrophy, a thick-walled left ventricle (LV) ultimately transitions to a dilated cardiomyopathy. There are scant data in humans demonstrating whether this transition occurs commonly without an interval myocardial infarction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p>\n              Participants (n=1282) from the Dallas Heart Study underwent serial cardiac magnetic resonance \u22487 years apart. Those with interval cardiovascular events and a dilated LV (increased LV end-diastolic volume [EDV] indexed to body surface area) at baseline were excluded. Multivariable linear regression models tested the association of concentric hypertrophy (increased LV mass and LV mass\/volume\n              <jats:sup>0.67<\/jats:sup>\n              ) with change in LVEDV. The study cohort had a median age of 44 years, 57% women, 43% black, and 11% (n=142) baseline concentric hypertrophy. The change in LVEDV in those with versus without concentric hypertrophy was 1 mL (\u22129 to 12) versus \u22122 mL (\u221211 to 7), respectively,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01. In multivariable linear regression models, concentric hypertrophy was associated with larger follow-up LVEDV (\n              <jats:italic>P<\/jats:italic>\n              \u22640.01). The progression to a dilated LV was uncommon (2%, n=25).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>In the absence of interval myocardial infarction, concentric hypertrophy was associated with a small, but significantly greater, increase in LVEDV after 7-year follow-up. However, the degree of LV enlargement was minimal, and few participants developed a dilated LV. These data suggest that if concentric hypertrophy does progress to a dilated cardiomyopathy, such a transition would occur over a much longer timeframe (eg, decades) and may be less common than previously thought.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00344903.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.117.003959","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T00:50:32Z","timestamp":1501807832000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Association of Concentric Left Ventricular Hypertrophy With Subsequent Change in Left Ventricular End-Diastolic Volume"],"prefix":"10.1161","volume":"10","author":[{"given":"Sonia","family":"Garg","sequence":"first","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine (S.G., J.A.d.L., S.A.M., A.P., I.J.N., J.D.B., M.H.D.), Department of Clinical Science (C.A., J.D.B.), and Department of Radiology (R.M., C.M., R.M.P.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"de Lemos","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine (S.G., J.A.d.L., S.A.M., A.P., I.J.N., J.D.B., M.H.D.), Department of Clinical Science (C.A., J.D.B.), and Department of Radiology (R.M., C.M., R.M.P.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A.","family":"Matulevicius","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine (S.G., J.A.d.L., S.A.M., A.P., I.J.N., J.D.B., M.H.D.), Department of Clinical Science (C.A., J.D.B.), and Department of Radiology (R.M., C.M., R.M.P.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colby","family":"Ayers","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine (S.G., J.A.d.L., S.A.M., A.P., I.J.N., J.D.B., M.H.D.), Department of Clinical Science (C.A., J.D.B.), and Department of Radiology (R.M., C.M., R.M.P.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambarish","family":"Pandey","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine (S.G., J.A.d.L., S.A.M., A.P., I.J.N., J.D.B., M.H.D.), Department of Clinical Science (C.A., J.D.B.), and Department of Radiology (R.M., C.M., R.M.P.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian J.","family":"Neeland","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine (S.G., J.A.d.L., S.A.M., A.P., I.J.N., J.D.B., M.H.D.), Department of Clinical Science (C.A., J.D.B.), and Department of Radiology (R.M., C.M., R.M.P.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarett D.","family":"Berry","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine (S.G., J.A.d.L., S.A.M., A.P., I.J.N., J.D.B., M.H.D.), Department of Clinical Science (C.A., J.D.B.), and Department of Radiology (R.M., C.M., R.M.P.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick","family":"McColl","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine (S.G., J.A.d.L., S.A.M., A.P., I.J.N., J.D.B., M.H.D.), Department of Clinical Science (C.A., J.D.B.), and Department of Radiology (R.M., C.M., R.M.P.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Maroules","sequence":"additional","affiliation":[{"name":"From the 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