{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:59:22Z","timestamp":1789563562727,"version":"build-2803163510"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Genetic evaluation is recommended in patients with unexplained dilated cardiomyopathy (DCM), but its diagnostic yield and prognostic relevance in unexplained isolated left ventricular dysfunction (LVdys) is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>\n              A total of 127 LVdys and 262 DCM patients underwent genetic screening. Long-term outcome consisted of a combined end point of life-threatening arrhythmia, heart transplantation, and death. At baseline, LVdys patients were younger and had less frequently New York Heart Association class \u22653 when compared with DCM (55\u00b113 versus 58\u00b112;\n              <jats:italic>P<\/jats:italic>\n              =0.019 and 21% versus 36%;\n              <jats:italic>P<\/jats:italic>\n              =0.003, respectively). The prevalence of familial disease and pathogenic mutations was similar in LVdys and DCM (45% versus 40%;\n              <jats:italic>P<\/jats:italic>\n              =0.37 and 19% versus 17%;\n              <jats:italic>P<\/jats:italic>\n              =0.61, respectively). After a follow-up of 56 (31\u201382) months, outcome did not differ in LVdys compared with DCM patients (hazard ratio, 0.83; 95% confidence interval, 0.47\u20131.45;\n              <jats:italic>P<\/jats:italic>\n              =0.51). Overall, outcome was less favorable in patients with a genetic mutation or familial disease when compared with those without (hazard ratio, 2.7; 95% confidence interval, 1.07\u20137.7;\n              <jats:italic>P<\/jats:italic>\n              =0.048 and hazard ratio, 2.2; 95% confidence interval, 1.2\u20134.2;\n              <jats:italic>P<\/jats:italic>\n              =0.013, respectively). Thus, the diagnostic yield of genetic testing in LVdys and DCM is similarly high. The presence of a gene mutation or familial predisposition results in an equally worse prognosis.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Genetic evaluation is advised in LVdys patients and should not merely be restricted to DCM.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.117.004682","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T11:20:17Z","timestamp":1521026417000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Prevalence of Pathogenic Gene Mutations and Prognosis Do Not Differ in Isolated Left Ventricular Dysfunction Compared With Dilated Cardiomyopathy"],"prefix":"10.1161","volume":"11","author":[{"given":"Mark R.","family":"Hazebroek","sequence":"first","affiliation":[{"name":"From the Department of Cardiology (M.R.H., J.V., M.H., L.S., L.v.M., R.D., H.J.G.M.C., H.-P.B.-L.R., S.H.), Department of Clinical Genetics (I.K., J.V., A.v.d.W., E.V., M.W., H.G.B.), and Department of Cardiovascular Sciences (S.H.), Leuven University, Belgium; Belgium and Netherlands Heart Institute, Utrecht (S.H.); and Maastricht University Medical Centre, The Netherlands (S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Krapels","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (M.R.H., J.V., M.H., L.S., L.v.M., R.D., H.J.G.M.C., H.-P.B.-L.R., S.H.), Department of Clinical Genetics (I.K., J.V., A.v.d.W., E.V., M.W., H.G.B.), and Department of Cardiovascular Sciences (S.H.), Leuven University, Belgium; Belgium and Netherlands Heart Institute, Utrecht (S.H.); and Maastricht University Medical Centre, The Netherlands (S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Job","family":"Verdonschot","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (M.R.H., J.V., M.H., L.S., L.v.M., R.D., H.J.G.M.C., H.-P.B.-L.R., S.H.), Department of Clinical Genetics (I.K., J.V., A.v.d.W., E.V., M.W., H.G.B.), and Department of Cardiovascular Sciences (S.H.), Leuven University, Belgium; Belgium and Netherlands Heart Institute, Utrecht (S.H.); and Maastricht University Medical Centre, The Netherlands (S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"van den Wijngaard","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (M.R.H., J.V., M.H., L.S., L.v.M., R.D., H.J.G.M.C., H.-P.B.-L.R., S.H.), Department of Clinical Genetics (I.K., J.V., A.v.d.W., E.V., M.W., H.G.B.), and Department of Cardiovascular Sciences (S.H.), Leuven University, Belgium; Belgium and Netherlands Heart Institute, Utrecht (S.H.); and Maastricht University Medical Centre, The Netherlands (S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Els","family":"Vanhoutte","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (M.R.H., J.V., M.H., L.S., L.v.M., R.D., H.J.G.M.C., H.-P.B.-L.R., S.H.), Department of Clinical Genetics (I.K., J.V., A.v.d.W., E.V., M.W., H.G.B.), and Department of Cardiovascular Sciences (S.H.), Leuven University, Belgium; Belgium and Netherlands Heart Institute, Utrecht (S.H.); and Maastricht University Medical Centre, The Netherlands (S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marije","family":"Hoos","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (M.R.H., J.V., M.H., L.S., L.v.M., R.D., H.J.G.M.C., H.-P.B.-L.R., S.H.), Department of Clinical Genetics (I.K., J.V., A.v.d.W., E.V., M.W., H.G.B.), and Department of Cardiovascular Sciences (S.H.), Leuven University, Belgium; Belgium and Netherlands Heart Institute, Utrecht (S.H.); and Maastricht University Medical Centre, The Netherlands (S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Snijders","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (M.R.H., J.V., M.H., L.S., L.v.M., R.D., H.J.G.M.C., H.-P.B.-L.R., S.H.), Department of Clinical Genetics (I.K., J.V., A.v.d.W., E.V., M.W., H.G.B.), and Department of Cardiovascular Sciences (S.H.), Leuven University, Belgium; Belgium and Netherlands Heart Institute, Utrecht (S.H.); and Maastricht University Medical Centre, The Netherlands (S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieke","family":"van Montfort","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (M.R.H., J.V., M.H., L.S., L.v.M., R.D., H.J.G.M.C., H.-P.B.-L.R., S.H.), Department of Clinical Genetics (I.K., J.V., A.v.d.W., E.V., M.W., H.G.B.), and Department of Cardiovascular Sciences (S.H.), Leuven University, Belgium; Belgium and Netherlands Heart Institute, Utrecht (S.H.); and Maastricht University Medical Centre, The Netherlands (S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryvonne","family":"Witjens","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (M.R.H., J.V., M.H., L.S., L.v.M., R.D., H.J.G.M.C., H.-P.B.-L.R., S.H.), Department of Clinical Genetics (I.K., J.V., A.v.d.W., E.V., M.W., H.G.B.), and Department of Cardiovascular Sciences (S.H.), Leuven University, Belgium; Belgium and Netherlands Heart Institute, Utrecht (S.H.); and Maastricht University Medical Centre, The Netherlands (S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Dennert","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (M.R.H., J.V., M.H., L.S., L.v.M., R.D., H.J.G.M.C., H.-P.B.-L.R., S.H.), Department of Clinical Genetics (I.K., J.V., A.v.d.W., E.V., M.W., H.G.B.), and Department of Cardiovascular Sciences (S.H.), Leuven University, Belgium; Belgium and Netherlands Heart Institute, Utrecht (S.H.); and Maastricht University Medical Centre, The Netherlands (S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry J.G.M.","family":"Crijns","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (M.R.H., J.V., M.H., L.S., L.v.M., R.D., H.J.G.M.C., H.-P.B.-L.R., S.H.), Department of Clinical Genetics (I.K., J.V., A.v.d.W., E.V., M.W., H.G.B.), and Department of Cardiovascular Sciences (S.H.), Leuven University, Belgium; Belgium and Netherlands Heart Institute, Utrecht (S.H.); and Maastricht University Medical Centre, The Netherlands (S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Brunner-La Rocca","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (M.R.H., J.V., M.H., L.S., L.v.M., R.D., H.J.G.M.C., H.-P.B.-L.R., S.H.), Department of Clinical Genetics (I.K., J.V., A.v.d.W., E.V., M.W., H.G.B.), and Department of Cardiovascular Sciences (S.H.), Leuven University, Belgium; Belgium and Netherlands Heart Institute, Utrecht (S.H.); and Maastricht University Medical Centre, The Netherlands (S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han G.","family":"Brunner","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (M.R.H., J.V., M.H., L.S., L.v.M., R.D., H.J.G.M.C., H.-P.B.-L.R., S.H.), Department of Clinical Genetics (I.K., J.V., A.v.d.W., E.V., M.W., H.G.B.), and Department of Cardiovascular Sciences (S.H.), Leuven University, Belgium; Belgium and Netherlands Heart Institute, Utrecht (S.H.); and Maastricht University Medical Centre, The Netherlands (S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Heymans","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (M.R.H., J.V., M.H., L.S., L.v.M., R.D., H.J.G.M.C., H.-P.B.-L.R., S.H.), Department of Clinical Genetics (I.K., J.V., A.v.d.W., E.V., M.W., H.G.B.), and Department of Cardiovascular Sciences (S.H.), Leuven University, Belgium; Belgium and Netherlands Heart Institute, Utrecht (S.H.); and Maastricht University Medical Centre, The Netherlands (S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2013.105"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.07.023"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv727"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.08.1644"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31825b07f8"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft013"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.030"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2004.07.013"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1998.1145"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1227764"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.109.912345"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv253"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu301"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02954-6"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.113.000374"}],"container-title":["Circulation: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCHEARTFAILURE.117.004682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:15:00Z","timestamp":1715562900000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCHEARTFAILURE.117.004682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1161\/CIRCHEARTFAILURE.117.004682"],"URL":"https:\/\/doi.org\/10.1161\/circheartfailure.117.004682","relation":{},"ISSN":["1941-3289","1941-3297"],"issn-type":[{"value":"1941-3289","type":"print"},{"value":"1941-3297","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"2017-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e004682"}}