{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:57:44Z","timestamp":1790539064610,"version":"4.1.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Gastrointestinal bleeding (GIB) is a common complication seen in patients supported with left ventricular assist devices (LVADs) and is related to increased inflammation and angiogenesis. Omega-3 is an unsaturated fatty acid that possesses anti-inflammatory and antiangiogenic properties. This study aims to assess the prophylactic efficacy of treatment with omega-3 on the incidence of GIB in LVAD patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p>\n              Among consecutive 166 LVAD patients enrolled in this analysis, 30 patients (49 years old and 26 male) received 4 g\/d of omega-3 therapy for 310\u00b187 days and 136 patients in the control group (58 years old and 98 male) were observed for 302\u00b1102 days. One-year GIB-free rate was significantly higher in the omega-3 group as compared with the control group (97% versus 73%;\n              <jats:italic>P<\/jats:italic>\n              =0.02). Omega-3 therapy was associated with the occurrence of GIB in both the univariate (hazard ratio, 0.12; 95% CI, 0.02\u20130.91;\n              <jats:italic>P<\/jats:italic>\n              =0.040) and multivariate Cox proportional hazard ratio analyses (hazard ratio, 0.13; 95% CI, 0.02\u20130.98;\n              <jats:italic>P<\/jats:italic>\n              =0.047). The frequency of GIB was significantly lower in the omega-3 group (0.08\u00b10.42 versus 0.37\u00b10.93 events\/y;\n              <jats:italic>P<\/jats:italic>\n              =0.01), accompanied by significantly lower blood product transfusion and shorter days in the hospital. The frequency of GIB remained lower among the omega-3 group after matching for patient background characteristics (96% versus 73%,\n              <jats:italic>P<\/jats:italic>\n              =0.028).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>LVAD patients treated with omega-3 had a significant increase in freedom from GIB. A randomized controlled study is warranted to evaluate the use of omega-3 in LVAD patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.118.005082","type":"journal-article","created":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T09:00:24Z","timestamp":1538643624000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Omega-3 Therapy Is Associated With Reduced Gastrointestinal Bleeding in Patients With Continuous-Flow Left Ventricular Assist Device"],"prefix":"10.1161","volume":"11","author":[{"given":"Teruhiko","family":"Imamura","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Chicago Medical Center, IL (T.I., A.N., D.R., G.K., J.R., N.S., S.K., B.S., B.C., N.N., G.S., N.U.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Chicago Medical Center, IL (T.I., A.N., D.R., G.K., J.R., N.S., S.K., B.S., B.C., N.N., G.S., N.U.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rodgers","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Chicago Medical Center, IL (T.I., A.N., D.R., G.K., J.R., N.S., S.K., B.S., B.C., N.N., G.S., N.U.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Chicago Medical Center, IL (T.I., A.N., D.R., G.K., J.R., N.S., S.K., B.S., B.C., N.N., G.S., N.U.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayant","family":"Raikhelkar","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Chicago Medical Center, IL (T.I., A.N., D.R., G.K., J.R., N.S., S.K., B.S., B.C., N.N., G.S., N.U.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitasha","family":"Sarswat","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Chicago Medical Center, IL (T.I., A.N., D.R., G.K., J.R., N.S., S.K., B.S., B.C., N.N., G.S., N.U.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Kalantari","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Chicago Medical Center, IL (T.I., A.N., D.R., G.K., J.R., N.S., S.K., B.S., B.C., N.N., G.S., N.U.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Chicago Medical Center, IL (T.I., A.N., D.R., G.K., J.R., N.S., S.K., B.S., B.C., N.N., G.S., N.U.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Chicago Medical Center, IL (T.I., A.N., D.R., G.K., J.R., N.S., S.K., B.S., B.C., N.N., G.S., N.U.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Narang","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Chicago Medical Center, IL (T.I., A.N., D.R., G.K., J.R., N.S., S.K., B.S., B.C., N.N., G.S., N.U.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Juricek","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Chicago Medical Center, IL (C.J., T.S., T.O., V.J.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Burkhoff","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, Cardiovascular Research Foundation, New York, NY (D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Chicago Medical Center, IL (C.J., T.S., T.O., V.J.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeyoshi","family":"Ota","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, Cardiovascular Research Foundation, New York, NY (D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valluvan","family":"Jeevanandam","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, Cardiovascular Research Foundation, New York, NY (D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Sayer","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Chicago Medical Center, IL (T.I., A.N., D.R., G.K., J.R., N.S., S.K., B.S., B.C., N.N., G.S., N.U.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Uriel","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Chicago Medical Center, IL (T.I., A.N., D.R., G.K., J.R., N.S., S.K., B.S., B.C., N.N., G.S., N.U.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.07.005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.12.039"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.10.001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.040246"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.05.016"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019692"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.06.001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2014.07.002"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2013.11.003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065703"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2018.01.011"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1610426"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602954"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2016.08.005"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.07.072"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.09.013"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.000206"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.02.010"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2015.10.001"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004500"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.09.013"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.01.922"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.08.002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980010003678"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.03.005"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.01.160"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122645"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3089303"}],"updated-by":[{"DOI":"10.1161\/hhf.0000000000000030","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000}}],"container-title":["Circulation: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCHEARTFAILURE.118.005082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:29:04Z","timestamp":1715563744000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCHEARTFAILURE.118.005082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1161\/CIRCHEARTFAILURE.118.005082"],"URL":"https:\/\/doi.org\/10.1161\/circheartfailure.118.005082","relation":{"correction":[{"id-type":"doi","id":"10.1161\/HHF.0000000000000030","asserted-by":"object"}]},"ISSN":["1941-3289","1941-3297"],"issn-type":[{"value":"1941-3289","type":"print"},{"value":"1941-3297","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"2018-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e005082"}}