{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:22:58Z","timestamp":1790734978216,"version":"4.1.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Cardiac amyloidosis is a substantially underdiagnosed disease, and contemporary estimates of the epidemiology of amyloidosis are lacking. This study aims to determine the incidence and prevalence of cardiac amyloidosis among Medicare beneficiaries from 2000 to 2012.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>\n              Medicare beneficiaries were counted in the prevalence cohort in each year they had (1) \u22651 principal or secondary\n              <jats:italic>International Classification of Diseases<\/jats:italic>\n              ,\n              <jats:italic>Ninth Revision<\/jats:italic>\n              code for amyloidosis and (2) \u22651 principal or secondary\n              <jats:italic>International Classification of Diseases, Ninth Revision<\/jats:italic>\n              code for heart failure or cardiomyopathy within 2 years after the systemic amyloidosis code. A beneficiary was counted in the incidence cohort only during the first year in which they met criteria. Primary outcomes included the prevalence and incidence of hospitalizations for cardiac amyloidosis. There were 4746 incident cases of cardiac amyloidosis in 2012 and 15\u2009737 prevalent cases in 2012. There was also a significant increase in the prevalence rate (8 to 17 per 100\u2009000 person-years) and incidence rate (18 to 55 per 100\u2009000 person-years) from 2000 to 2012, most notable after 2006. Incidence and prevalence increased substantially more among men, the elderly, and in blacks.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The incidence and prevalence rates of cardiac amyloidosis are higher than previously thought. The incidence and prevalence rates of cardiac amyloidosis among hospitalized patients have increased since 2000, particularly among specific patient subgroups and after 2006, suggesting improved amyloidosis awareness and higher diagnostic rates with noninvasive imaging. In light of these trends, cardiac amyloidosis should be considered during the initial work up of patients \u226565 years old hospitalized with heart failure.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.118.005407","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T09:00:20Z","timestamp":1559898020000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":235,"title":["Epidemiology of Cardiac Amyloidosis\u2013Associated Heart Failure Hospitalizations Among Fee-for-Service Medicare Beneficiaries in the United States"],"prefix":"10.1161","volume":"12","author":[{"given":"Lauren G.","family":"Gilstrap","sequence":"first","affiliation":[{"name":"Dartmouth Hitchcock Medical Center, Heart and Vascular Center, Lebanon, NH (L.G.G.)."},{"name":"The Dartmouth Institute, Geisel Medical School at Dartmouth, Hanover, NH (L.G.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Dominici","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, T.H. Chan Harvard School of Public Health, Boston, MA (F.D., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, T.H. Chan Harvard School of Public Health, Boston, MA (F.D., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Samir","family":"El-Sady","sequence":"additional","affiliation":[{"name":"Cardiac Amyloidosis Program (M.S.E.-S., R.H.F., S.D.), Brigham and Women\u2019s Hospital, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitoj","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine and Department of Radiology (A.S., M.F.D.C., S.D.), Brigham and Women\u2019s Hospital, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo F.","family":"Di Carli","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine (M.F.D.C., R.H.F., S.D.), Brigham and Women\u2019s Hospital, Boston, MA."},{"name":"Division of Nuclear Medicine and Department of Radiology (A.S., M.F.D.C., S.D.), Brigham and Women\u2019s Hospital, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney H.","family":"Falk","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine (M.F.D.C., R.H.F., S.D.), Brigham and Women\u2019s Hospital, Boston, MA."},{"name":"Cardiac Amyloidosis Program (M.S.E.-S., R.H.F., S.D.), Brigham and Women\u2019s Hospital, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Dorbala","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine (M.F.D.C., R.H.F., S.D.), Brigham and Women\u2019s Hospital, Boston, MA."},{"name":"Cardiac Amyloidosis Program (M.S.E.-S., R.H.F., S.D.), Brigham and Women\u2019s Hospital, Boston, MA."},{"name":"Division of Nuclear Medicine and Department of Radiology (A.S., M.F.D.C., S.D.), Brigham and Women\u2019s Hospital, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024438"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2013.11.004"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/91.2.141"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03868.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-11-751628"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805689"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716153"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-6773.2012.01411.x"},{"key":"e_1_3_3_10_2","unstructured":"Agency for Healthcare Research and Quality. 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