{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:53:54Z","timestamp":1787018034860,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cardiomyopathy is a common complication among muscular dystrophy (MD) patients and often results in advanced heart failure and premature death. In spite of this, there is hesitancy to consider heart transplantation (HTx). This study describes the HTx outcomes in patients with MD in the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      All HTx in the United Network for Organ Sharing database from October 1, 1987, to March 31, 2016, were identified. Two patient groups were created: MD cohort (n=81), and a cohort of all other cardiomyopathies, called cardiomyopathy-unmatched (n=41 317). Propensity score matching (ratio 1:2) was performed on transplant age, gender transplant year, renal function, and inotropic support at transplant to form a cardiomyopathy-matched cohort (n=162). Patient characteristics and posttransplant outcomes were compared. In the 81 patients with MD, Becker was the most common type (42%\u201352%). All the analyzed preoperative characteristics did not statistically differ between the MD and cardiomyopathy-matched cohorts except ventricular assist device use (16% versus 30%;\n                      <jats:italic>P<\/jats:italic>\n                      =0.017), ventilator support (0% versus 6%;\n                      <jats:italic>P<\/jats:italic>\n                      =0.031), and donor race mismatch (30% versus 55%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Median time on waitlist was not statistically different between the 2 groups (52 versus 59 days;\n                      <jats:italic>P<\/jats:italic>\n                      =0.12). Posttransplant survival of MD cohort was not statistically different compared with cardiomyopathy-matched cohort (\n                      <jats:italic>P<\/jats:italic>\n                      =0.18; hazard ratio [95% CI], 0.71 [0.42\u20131.18]) and was better than the cardiomyopathy-unmatched cohort (\n                      <jats:italic>P<\/jats:italic>\n                      =0.004; hazard ratio [95% CI], 0.53 [0.34\u20130.82]). Among the types of MD, no statistical difference was observed in posttransplant survival of Becker MD versus non-Becker MD (\n                      <jats:italic>P<\/jats:italic>\n                      =0.12; hazard ratio [95% CI], 2.17 [0.79\u20136.01]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Patients with MD undergoing HTx had similar long-term posttransplant survival compared with matched cardiomyopathy-related HTx recipients. HTx appears to be an effective treatment for a select group of muscular dystrophy patients with end-stage heart failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circheartfailure.118.005447","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T05:00:20Z","timestamp":1585285220000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Heart Transplantation in Muscular Dystrophy Patients"],"prefix":"10.1161","volume":"13","author":[{"given":"Dennis","family":"Wells","sequence":"first","affiliation":[{"name":"From the Department of Cardiothoracic Surgery (D.W.), University of Cincinnati College of Medicine, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raheel","family":"Rizwan","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH (R.R., J.L.J., R.B., T.D.R., A.L., C.C., F.Z., D.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Jefferies","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (J.L.J., R.B., A.L., C.C., D.L.M.), University of Cincinnati College of Medicine, OH"},{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH (R.R., J.L.J., R.B., T.D.R., A.L., C.C., F.Z., D.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"3rd","given":"Roosevelt","family":"Bryant","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (J.L.J., R.B., A.L., C.C., D.L.M.), University of Cincinnati College of Medicine, OH"},{"name":"Department of Surgery (R.B., F.Z., D.L.M.), University of Cincinnati College of Medicine, OH"},{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH (R.R., J.L.J., R.B., T.D.R., A.L., C.C., F.Z., D.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Ryan","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH (R.R., J.L.J., R.B., T.D.R., A.L., C.C., F.Z., D.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Lorts","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (J.L.J., R.B., A.L., C.C., D.L.M.), University of Cincinnati College of Medicine, OH"},{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH (R.R., J.L.J., R.B., T.D.R., A.L., C.C., F.Z., D.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (J.L.J., R.B., A.L., C.C., D.L.M.), University of Cincinnati College of Medicine, OH"},{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH (R.R., J.L.J., R.B., T.D.R., A.L., C.C., F.Z., D.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhan","family":"Zafar","sequence":"additional","affiliation":[{"name":"Department of Surgery (R.B., F.Z., D.L.M.), University of Cincinnati College of Medicine, OH"},{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH (R.R., J.L.J., R.B., T.D.R., A.L., C.C., F.Z., D.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Morales","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (J.L.J., R.B., A.L., C.C., D.L.M.), University of Cincinnati College of Medicine, OH"},{"name":"Department of Surgery (R.B., F.Z., D.L.M.), University of Cincinnati College of Medicine, OH"},{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH (R.R., J.L.J., R.B., T.D.R., A.L., C.C., F.Z., D.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","first-page":"1119","article-title":"Prevalence of Duchenne\/Becker muscular dystrophy among males aged 5\u201324 years: four states, 2007.","volume":"58","author":"Centers for Disease Control and Prevention","year":"2009","unstructured":"Centers for Disease Control and Prevention. Prevalence of Duchenne\/Becker muscular dystrophy among males aged 5\u201324 years: four states, 2007. MMWR Morb Mortal Wkly Rep. 2009;58:1119\u20131122.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_5_3_2","unstructured":"CDC. \u201cFacts about Muscular Dystrophy.\u201d Centers for Disease Control and Prevention. Centers for Disease Control and Prevention. Available at: https:\/\/www.cdc.gov\/ncbddd\/musculardystrophy\/facts.html. 07 April 2016. Accessed 27 February 2017."},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.01.018"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000068446"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0960-8966(02)00213-4"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2012.06.256"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.110.960740"},{"key":"e_1_3_5_9_2","first-page":"804","article-title":"Heart transplantation in patients with muscular dystrophy associated with end-stage cardiomyopathy.","volume":"12","author":"Rees W","year":"1993","unstructured":"Rees, W, Sch\u00fcler, S, Hummel, M, Hetzer, R. Heart transplantation in patients with muscular dystrophy associated with end-stage cardiomyopathy. J Heart Lung Transplant. 1993;12:804\u2013807.","journal-title":"J Heart Lung Transplant"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.08.030"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.5582\/irdr.2017.01024"},{"key":"e_1_3_5_12_2","first-page":"121","article-title":"Improvement of survival in Duchenne Muscular Dystrophy: retrospective analysis of 835 patients.","volume":"31","author":"Passamano L","year":"2012","unstructured":"Passamano, L, Taglia, A, Palladino, A, Viggiano, E, D\u2019Ambrosio, P, Scutifero, M, Rosaria Cecio, M, Torre, V, DE Luca, F, Picillo, E, et al. Improvement of survival in Duchenne Muscular Dystrophy: retrospective analysis of 835 patients. Acta Myol. 2012;31:121\u2013125.","journal-title":"Acta Myol"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.015151"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000050"}],"container-title":["Circulation: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCHEARTFAILURE.118.005447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T21:37:41Z","timestamp":1715549861000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCHEARTFAILURE.118.005447"}},"subtitle":["Is it a Viable Option?"],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1161\/CIRCHEARTFAILURE.118.005447"],"URL":"https:\/\/doi.org\/10.1161\/circheartfailure.118.005447","relation":{},"ISSN":["1941-3289","1941-3297"],"issn-type":[{"value":"1941-3289","type":"print"},{"value":"1941-3297","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"2018-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e005447"}}