{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:38:08Z","timestamp":1790217488664,"version":"4.1.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>\n              As pathogenic variants in the gene for\n              <jats:italic>RBM20<\/jats:italic>\n              appear with a frequency of 6% among Danish patients with dilated cardiomyopathy (DCM), it was the aim to investigate the associated disease expression in affected families.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p>\n              Clinical investigations were routinely performed in DCM index-patients and their relatives. In addition, \u226576 recognized and likely DCM-genes were investigated. DNA-sequence-variants within\n              <jats:italic>RBM20<\/jats:italic>\n              were considered suitable for genetic testing when they fulfilled the criteria of (1) being pathogenic according to the American College of Medical Genetics and Genomics-classification, (2) appeared with an allele frequency of &lt;1:10.000, and (3) segregated with DCM in \u22657 affected individuals. A total of 80 individuals from 15 families carried 5 different pathogenic\n              <jats:italic>RBM20<\/jats:italic>\n              -variants considered suitable for genetic testing. The penetrance was 66% (53\/80) and age-dependent. Males were both significantly younger and had lower ejection fraction at diagnosis than females (age, 29\u00b111 versus 48\u00b112 years;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01; ejection fraction, 29\u00b113% versus 38\u00b19%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). Furthermore, 11 of 31 affected males needed a cardiac transplant while none of 22 affected females required this treatment (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Thirty percent of\n              <jats:italic>RBM20<\/jats:italic>\n              -carriers with DCM died suddenly or experienced severe ventricular arrhythmias although no adverse events were identified among healthy\n              <jats:italic>RBM20<\/jats:italic>\n              -carriers with a normal cardiac investigation. The event-free survival of male\n              <jats:italic>RBM20<\/jats:italic>\n              -carriers was significantly shorter compared with female carriers (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>\n              The disease expression associated with pathogenic\n              <jats:italic>RBM20<\/jats:italic>\n              -variants was severe especially in males. The findings of the current study suggested that close clinical follow-up of\n              <jats:italic>RBM20<\/jats:italic>\n              -carriers is important which may ensure early detection of disease development and thereby improve management.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.118.005700","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T09:00:36Z","timestamp":1552640436000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":89,"title":["Pathogenic\n            <i>RBM20<\/i>\n            -Variants Are Associated With a Severe Disease Expression in Male Patients With Dilated Cardiomyopathy"],"prefix":"10.1161","volume":"12","author":[{"given":"Thomas Morris","family":"Hey","sequence":"first","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, Denmark (T.M.H., J.E.M., J.M.)."},{"name":"Faculty of Health Sciences, University of Southern Denmark, Odense (T.M.H., J.E.M., J.M.)."},{"name":"Odense Patient Data Explorative Network (OPEN), University of Southern Denmark, Odense (T.M.H., J.E.M., J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten B.","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Denmark (T.B.R., H.M., H.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aalborg University Hospital, Denmark (T.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads Malik","family":"Aagaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Hospital Lillebaelt, Vejle, Denmark (M.M.A., M.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Harbo","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Hospital Lillebaelt, Vejle, Denmark (M.M.A., M.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"M\u00f8lgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Denmark (T.B.R., H.M., H.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob E.","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, Denmark (T.M.H., J.E.M., J.M.)."},{"name":"Faculty of Health Sciences, University of Southern Denmark, Odense (T.M.H., J.E.M., J.M.)."},{"name":"Odense Patient Data Explorative Network (OPEN), University of Southern Denmark, Odense (T.M.H., J.E.M., J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Eiskj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Denmark (T.B.R., H.M., H.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Mogensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, Denmark (T.M.H., J.E.M., J.M.)."},{"name":"Faculty of Health Sciences, University of Southern Denmark, Odense (T.M.H., J.E.M., J.M.)."},{"name":"Odense Patient Data Explorative Network (OPEN), University of Southern Denmark, Odense (T.M.H., J.E.M., J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm342"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.08.017"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.3.564"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-2-200507190-00009"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv253"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.255"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.05.038"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.113.000011"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-8062.2010.00198.x"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.10.016"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvw192"},{"key":"e_1_3_4_14_2","unstructured":"Statistics Denmark. https:\/\/www.dst.dk\/en\/Statistik\/emner\/befolkning-og-valg\/befolkning-og-befolkningsfremskrivning\/folketal. 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