{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T14:18:29Z","timestamp":1772288309139,"version":"3.50.1"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>The coronary vasculature encounters a reduction in pulsatility after implementing durable continuous-flow left ventricular assist device (CF-LVAD) circulatory support. Evidence exists that appropriate pulsatility is required to maintain endothelial cell homeostasis. We hypothesized that coronary artery endothelial function would be impaired after CF-LVAD intervention.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>\n              Coronary arteries from patients with end-stage heart failure caused by ischemic cardiomyopathy (ICM; n=16) or non-ICM (n=22) cardiomyopathy were isolated from the left ventricular apical core, which was removed for the CF-LVAD implantation. In 11 of these patients, paired coronary arteries were obtained from an adjacent region of myocardium after the CF-LVAD intervention (n=6 ICM, 5 non-ICM). Vascular function was assessed ex vivo using isometric tension procedures in these patients and in 7 nonfailing donor controls. Maximal endothelium-dependent vasorelaxation to BK (bradykinin; 10\n              <jats:sup>\u2212<\/jats:sup>\n              <jats:sup>6<\/jats:sup>\n              \u201310\n              <jats:sup>\u2212<\/jats:sup>\n              <jats:sup>10<\/jats:sup>\n              M) was blunted (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) in arteries from patients with ICM compared with non-ICM and donor controls, whereas responses to sodium nitroprusside (10\n              <jats:sup>\u22124<\/jats:sup>\n              \u201310\n              <jats:sup>\u22129<\/jats:sup>\n              M) were similar among the groups. Contrary to our hypothesis, vasorelaxation responses to BK and sodium nitroprusside were similar before and 219\u00b137 days after CF-LVAD support. Of these patients, an exploratory subgroup analysis revealed that BK-induced coronary artery vasorelaxation was greater (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) after (87\u00b16%) versus before (54\u00b114%) CF-LVAD intervention in ICM patients, whereas sodium nitroprusside\u2013evoked responses were similar.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Coronary artery endothelial function is not impaired by durable CF-LVAD support and in ICM patients appears to be improved. Investigating coronary endothelial function using in vivo approaches in a larger patient population is warranted.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.119.006085","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T09:00:16Z","timestamp":1566205216000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of Continuous-Flow Left Ventricular Assist Device Support on Coronary Artery Endothelial Function in Ischemic and Nonischemic Cardiomyopathy"],"prefix":"10.1161","volume":"12","author":[{"given":"J. David","family":"Symons","sequence":"first","affiliation":[{"name":"Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City (J.D.S., L.D., N.D., T.B., J.M.C., S.G.D.)."},{"name":"Department of Internal Medicine, Division of Endocrinology, Metabolism, and Diabetes (J.D.S.), University of Utah, Salt Lake City."},{"name":"Molecular Medicine Program (J.D.S., P.F., L.M., N.A.D., I.T., S.N., S.G.D.), University of Utah, Salt Lake City."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance","family":"Deeter","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City (J.D.S., L.D., N.D., T.B., J.M.C., S.G.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Deeter","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City (J.D.S., L.D., N.D., T.B., J.M.C., S.G.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor","family":"Bonn","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City (J.D.S., L.D., N.D., T.B., J.M.C., S.G.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Min","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City (J.D.S., L.D., N.D., T.B., J.M.C., S.G.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ferrin","sequence":"additional","affiliation":[{"name":"Molecular Medicine Program (J.D.S., P.F., L.M., N.A.D., I.T., S.N., S.G.D.), University of Utah, Salt Lake City."},{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute (P.F., L.M., N.A.D., I.T., S.N., C.H.S., S.G.D.), University of Utah, Salt Lake City."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"McCreath","sequence":"additional","affiliation":[{"name":"Molecular Medicine Program (J.D.S., P.F., L.M., N.A.D., I.T., S.N., S.G.D.), University of Utah, Salt Lake City."},{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute (P.F., L.M., N.A.D., I.T., S.N., C.H.S., S.G.D.), University of Utah, Salt Lake City."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos A.","family":"Diakos","sequence":"additional","affiliation":[{"name":"Molecular Medicine Program (J.D.S., P.F., L.M., N.A.D., I.T., S.N., S.G.D.), University of Utah, Salt Lake City."},{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute (P.F., L.M., N.A.D., I.T., S.N., C.H.S., S.G.D.), University of Utah, Salt Lake 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