{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:59:08Z","timestamp":1789469948687,"version":"build-2803163510"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acute decompensated heart failure (ADHF) is a highly morbid condition among adults. Little is known about outcomes in children with ADHF. We analyzed the Pediatric Cardiac Critical Care Consortium registry to determine the epidemiology, contemporary treatments, and predictors of mortality in critically ill children with ADHF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Cardiac intensive care unit (CICU) patients \u226418 years of age meeting Pediatric Cardiac Critical Care Consortium criteria for ADHF were included. ADHF was defined as systolic or diastolic dysfunction requiring continuous vasoactive or diuretic infusion, respiratory support, or mechanical circulatory support. Demographics, diagnosis, therapies, complications, and mortality are described for the cohort. Predictors of CICU mortality were identified using logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 26 294 consecutive admissions (23 centers), 1494 (6%) met criteria for analysis. Median age was 0.93 years (interquartile range, 0.1\u20139.3 years). Patients with congenital heart disease (CHD) comprised 57% of the cohort. Common therapies included the following: vasoactive infusions (88%), central venous catheters (86%), mechanical ventilation (59%), and high flow nasal cannula (46%). Common complications were arrhythmias (19%), cardiac arrest (10%), sepsis (7%), and acute renal failure requiring dialysis (3%). Median length of CICU stay was 7.9 days (interquartile range, 3\u201318 days) and the CICU readmission rate was 22%. Overall, CICU mortality was 15% although higher for patients with CHD versus non-CHD (19% versus 11%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Independent risk factors associated with CICU mortality included age &lt;30 days, CHD, vasoactive infusions, ventricular tachycardia, mechanical ventilation, sepsis, pulmonary hypertension, extracorporeal membrane oxygenation, and cardiac arrest.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>ADHF in children is characterized by comorbidities, high mortality rates, and frequent readmission, especially among patients with CHD. Opportunities exist to determine best practices around appropriate use of mechanical support, cardiac arrest prevention, and optimal heart transplantation candidacy to improve outcomes for these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circheartfailure.119.006101","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T06:50:46Z","timestamp":1587106246000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":62,"title":["Epidemiology and Outcomes of Acute Decompensated Heart Failure in Children"],"prefix":"10.1161","volume":"13","author":[{"given":"Javier J.","family":"Lasa","sequence":"first","affiliation":[{"name":"Division of Critical Care Medicine (J.J.L., P.A.C., J.E., L.S.S.), Texas Children\u2019s Hospital, Baylor College of Medicine, Houston."},{"name":"Division of Cardiology (J.J.L., A.G.C., J.F.P.), Texas Children\u2019s Hospital, Baylor College of Medicine, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gaies","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Michigan Medical School, Ann Arbor (M.G., K.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Bush","sequence":"additional","affiliation":[{"name":"PC4 Data Coordinating Center, Michigan Congenital Heart Outcomes Research and Discovery Unit, University of Michigan, Ann Arbor (L.B., W.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenying","family":"Zhang","sequence":"additional","affiliation":[{"name":"PC4 Data Coordinating Center, Michigan Congenital Heart Outcomes Research and Discovery Unit, University of Michigan, Ann Arbor (L.B., W.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mousumi","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor (M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Alten","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, OH (J.A.A., A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Butts","sequence":"additional","affiliation":[{"name":"UT Southwestern Department of Pediatrics, Division of Cardiology, UT Southwestern Medical Center, Dallas, TX (R.J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio G.","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Division of Cardiology (J.J.L., A.G.C., J.F.P.), Texas Children\u2019s Hospital, Baylor College of Medicine, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Checchia","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine (J.J.L., P.A.C., J.E., L.S.S.), Texas Children\u2019s Hospital, Baylor College of Medicine, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Elhoff","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine (J.J.L., P.A.C., J.E., L.S.S.), Texas Children\u2019s Hospital, Baylor College of Medicine, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Lorts","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, OH (J.A.A., A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph W.","family":"Rossano","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Children\u2019s Hospital of Philadelphia, University of Pennsylvania School of Medicine (J.W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Michigan Medical School, Ann Arbor (M.G., K.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara S.","family":"Shekerdemian","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine (J.J.L., P.A.C., J.E., L.S.S.), Texas Children\u2019s Hospital, Baylor College of Medicine, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack F.","family":"Price","sequence":"additional","affiliation":[{"name":"Division of Cardiology (J.J.L., A.G.C., J.F.P.), Texas Children\u2019s Hospital, Baylor College of Medicine, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Pediatric Cardiac Critical Care Consortium (PC)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.06.002"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2013.08.006"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.06.003"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.072"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.06.339"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-010-2113-0"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.08.005"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq002"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2006.01.001"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-6-23"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.04.028"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2012.06.473"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-017-1712-8"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.02.009"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2014.10.011"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.964510"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951114001450"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951115001833"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1017\/S104795111000185X"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000153"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.07.011"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.01.1227"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S82379"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivx066"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.022"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.10.041"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.11.007"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx456"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.03.012"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912613"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001273"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000208440.66756.C2"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2006.05.009"}],"container-title":["Circulation: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCHEARTFAILURE.119.006101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T21:37:43Z","timestamp":1715549863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCHEARTFAILURE.119.006101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1161\/CIRCHEARTFAILURE.119.006101"],"URL":"https:\/\/doi.org\/10.1161\/circheartfailure.119.006101","relation":{},"ISSN":["1941-3289","1941-3297"],"issn-type":[{"value":"1941-3289","type":"print"},{"value":"1941-3297","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"2019-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e006101"}}