{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:27:24Z","timestamp":1793831244094,"version":"4.6.1"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Currently, women represent &lt;25% of heart transplant recipients. Reasons for this female underrepresentation have been attributed to selection and referral bias and potentially poorer outcomes in female recipients. The aim of this study was to compare long-term posttransplant survival between men and women, when matched for recipient and donor characteristics.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>\n              Using the International Society for Heart and Lung Transplantation Registry, we performed descriptive analyses and estimated overall freedom from posttransplant death stratified by sex using Kaplan-Meier survival methods. Male and female recipients were matched according to the Index for Mortality Prediction After Cardiac Transplantation and Donor Risk Index score using 1:1 propensity score matching. The study cohort comprised 34\u2009198 heart transplant recipients (76.3% men, 23.7% women) between 2004 and 2014. Compared with men, women were more likely younger (51 [39\u201359] versus 55 [46\u201361] years;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and had a different distribution of heart failure etiology (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). In general, the prevalence of comorbidities was lower in women than in men. Women were less likely to have diabetes mellitus (19.1% versus 26.2%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), hypertension (40.7% versus 47.9%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), peripheral vascular disease (2.4% versus 3.3%;\n              <jats:italic>P<\/jats:italic>\n              =0.002), tobacco use (36.5% versus 52.3%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and prior cardiovascular surgery (38.6% versus 50.7%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Women were more likely to have a history of malignancy (10.5% versus 5.3%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), require intravenous inotropes (41.4% versus 37.2%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and were less likely supported by an intra-aortic balloon pump (3.3% versus 3.8%;\n              <jats:italic>P<\/jats:italic>\n              =0.03) or durable ventricular assist device (22% versus 31.5%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Transplanted male recipients had a higher Index for Mortality Prediction After Cardiac Transplantation score (5 [2\u20137] versus 4 [1\u20136];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). When male and female heart transplant recipients were matched for recipient and donor characteristics, there was no significant survival difference (\n              <jats:italic>P<\/jats:italic>\n              =0.57).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Overall survival does not differ between men and women after cardiac transplantation. Women who survive to heart transplantation appear to have lower risk features than male recipients but receive hearts from higher risk donors.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.119.006218","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T09:00:29Z","timestamp":1570698029000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":86,"title":["Survival Outcomes After Heart Transplantation"],"prefix":"10.1161","volume":"12","author":[{"given":"Yasbanoo","family":"Moayedi","sequence":"first","affiliation":[{"name":"Section of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support, Department of Medicine, Stanford University, CA (Y.M., J.J.T., K.K.K.)."},{"name":"Ted Rogers Centre of Excellence in Heart Function, Peter Munk Cardiac Centre, University Health Network, Toronto, Canada (Y.M., C.P.S.F., H.J.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Po S.","family":"Fan","sequence":"additional","affiliation":[{"name":"Ted Rogers Centre of Excellence in Heart Function, Peter Munk Cardiac Centre, University Health Network, Toronto, Canada (Y.M., C.P.S.F., H.J.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wida S.","family":"Cherikh","sequence":"additional","affiliation":[{"name":"United Network for Organ Sharing, Richmond, VA (W.S.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Stehlik","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Heart Transplant, University of Utah School of Medicine, Salt Lake City (J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Teuteberg","sequence":"additional","affiliation":[{"name":"Section of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support, Department of Medicine, Stanford University, CA (Y.M., J.J.T., K.K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Ross","sequence":"additional","affiliation":[{"name":"Ted Rogers Centre of Excellence in Heart Function, Peter Munk Cardiac Centre, University Health Network, Toronto, Canada (Y.M., C.P.S.F., H.J.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran K.","family":"Khush","sequence":"additional","affiliation":[{"name":"Section of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support, Department of Medicine, Stanford University, CA (Y.M., J.J.T., K.K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.07.022"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12307"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.08.029"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.037369"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.91.11.2753"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.108.844183"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-77932-4_24"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.02.005"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1331467"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.11.456"},{"key":"e_1_3_3_12_2","unstructured":"International Thoracic Organ Transplant (TTX) Registry Data Slides (Adult heart transplant slide 57). ISHLT: The International Society for Heart & Lung Transplantation. Available at: https:\/\/ishltregistries.org\/registries\/slides.asp. Accessed August 13 2019."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.12.055"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.10.004"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880080230"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.985515"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1062-1458(02)00927-3"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.09.014"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000558"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2018.08.010"},{"key":"e_1_3_3_21_2","unstructured":"International Thoracic Organ Transplant (TTX) Registry Quarterly Data Reports. ISHLT: The International Society for Heart & Lung Transplantation. Available at: https:\/\/ishltregistries.org\/registries\/quarterlyDataReportStep3.asp?organ=HR&rptType=tx_demo. Accessed April 16 2019."},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.114.001607"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.116.003635"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.01.008"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.09.017"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2013.09.005"}],"container-title":["Circulation: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCHEARTFAILURE.119.006218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:47:44Z","timestamp":1715564864000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCHEARTFAILURE.119.006218"}},"subtitle":["Does Recipient Sex Matter?"],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1161\/CIRCHEARTFAILURE.119.006218"],"URL":"https:\/\/doi.org\/10.1161\/circheartfailure.119.006218","relation":{},"ISSN":["1941-3289","1941-3297"],"issn-type":[{"value":"1941-3289","type":"print"},{"value":"1941-3297","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"2019-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e006218"}}