{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:49:04Z","timestamp":1790336944935,"version":"4.1.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Invasive hemodynamic evaluation through right heart catheterization plays an essential role in the diagnosis, categorization, and risk stratification of patients with pulmonary hypertension.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Subjects enrolled in the PVDOMICS (Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics) program undergo an extensive invasive hemodynamic evaluation that includes repeated measurements at rest and during several provocative physiological challenges. It is a National Institutes of Health\/National Heart, Lung, and Blood Institute initiative to reclassify pulmonary hypertension groups based on clustered phenotypic and phenomic characteristics. At a subset of centers, participants also undergo an invasive cardiopulmonary exercise test to assess changes in hemodynamics and gas exchange during exercise.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>When coupled with other physiological testing and blood -omic analyses involved in the PVDOMICS study, the comprehensive right heart catheterization protocol described here holds promise to clarify the diagnosis and clustering of pulmonary hypertension patients into cohorts beyond the traditional 5 World Symposium on Pulmonary Hypertension groups. This article will describe the methods applied for invasive hemodynamic characterization in the PVDOMICS program.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT02980887.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.119.006363","type":"journal-article","created":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T10:00:27Z","timestamp":1582538427000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["Comprehensive Diagnostic Evaluation of Cardiovascular Physiology in Patients With Pulmonary Vascular Disease"],"prefix":"10.1161","volume":"13","author":[{"given":"W. H. Wilson","family":"Tang","sequence":"first","affiliation":[{"name":"Division of Heart Failure &amp; Transplant Medicine, Department of Cardiovascular Medicine (W.H.W.T., M.S.J.), Cleveland Clinic, Cleveland, OH."},{"name":"Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute (W.H.W.T., J.D.W.), Cleveland Clinic, Cleveland, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer D.","family":"Wilcox","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute (W.H.W.T., J.D.W.), Cleveland Clinic, Cleveland, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam S.","family":"Jacob","sequence":"additional","affiliation":[{"name":"Division of Heart Failure &amp; Transplant Medicine, Department of Cardiovascular Medicine (W.H.W.T., M.S.J.), Cleveland Clinic, Cleveland, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika B.","family":"Rosenzweig","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics and Medicine, Columbia University Medical Center, New York, NY (E.B.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry A.","family":"Borlaug","sequence":"additional","affiliation":[{"name":"Division of Circulatory Failure, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (B.A.B., R.P.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Frantz","sequence":"additional","affiliation":[{"name":"Division of Circulatory Failure, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (B.A.B., R.P.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Hassoun","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD (P.M.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna R.","family":"Hemnes","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (A.R.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas S.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Critical Care and Sleep Medicine, Tufts University Medical Center, Boston MA (N.S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn M.","family":"Horn","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Cornell University Medical Center, New York, NY (E.M.H., H.S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsimran S.","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Cornell University Medical Center, New York, NY (E.M.H., H.S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Systrom","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA (D.M.S., A.B.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Tedford","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC (R.J.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca R.","family":"Vanderpool","sequence":"additional","affiliation":[{"name":"Division of Translational and Regenerative Medicine, (R.R.V.)"},{"name":"University of Arizona College of Medicine, Tucson, AZ (R.R.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron B.","family":"Waxman","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA (D.M.S., A.B.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xiao","sequence":"additional","affiliation":[{"name":"National Heart, Lung and Blood Institute, Bethesda MD (L.X.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A.","family":"Leopold","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston MA (J.A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz P.","family":"Rischard","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, Critical Care &amp; 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