{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:29:06Z","timestamp":1789187346190,"version":"build-2803163510"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>\n              Abnormally high cytosolic Na\n              <jats:sup>+<\/jats:sup>\n              concentrations in advanced heart failure impair myocardial contractility. Stimulation of the membrane Na\n              <jats:sup>+<\/jats:sup>\n              -K\n              <jats:sup>+<\/jats:sup>\n              pump should lower Na\n              <jats:sup>+<\/jats:sup>\n              concentrations, and the \u03b23 adrenoceptor (\u03b23 AR) mediates pump stimulation in myocytes. We examined if \u03b23 AR-selective agonists given in vivo increase myocyte Na\n              <jats:sup>+<\/jats:sup>\n              -K\n              <jats:sup>+<\/jats:sup>\n              pump activity and reverse organ congestion in severe heart failure (HF).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              Indices for HF were lung-, heart-, and liver: body weight ratios and ascites after circumflex coronary artery ligation in rabbits. Na\n              <jats:sup>+<\/jats:sup>\n              -K\n              <jats:sup>+<\/jats:sup>\n              pump current, I\n              <jats:sub>p<\/jats:sub>\n              , was measured in voltage-clamped myocytes from noninfarct myocardium. Rabbits were treated with the \u03b23 AR agonists CL316,243 or ASP9531, starting 2 weeks after coronary ligation.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Coronary ligation caused ascites in most rabbits, significantly increased lung-, heart-, and liver: body weight ratios, and decreased I\n              <jats:sub>p<\/jats:sub>\n              relative to that for 10 sham-operated rabbits. Treatment with CL316,243 for 3 days significantly reduced lung-, heart-, and liver: body weight ratios and prevalence of ascites in 8 rabbits with HF relative to indices for 13 untreated rabbits with HF. It also increased I\n              <jats:sub>p<\/jats:sub>\n              significantly to levels of myocytes from sham-operated rabbits. Treatment with ASP9531 for 14 days significantly reduced indices of organ congestion in 6 rabbits with HF relative to indices of 6 untreated rabbits, and it eliminated ascites. \u03b23 AR agonists did not significantly change heart rates or blood pressures.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>\n              Parallel \u03b23 AR agonists-induced reversal of Na\n              <jats:sup>+<\/jats:sup>\n              -K\n              <jats:sup>+<\/jats:sup>\n              pump inhibition and indices of congestion suggest pump inhibition is a useful target for treatment with \u03b23 AR agonists in congestive HF.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.119.006753","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T09:00:24Z","timestamp":1598432424000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Targeting Cardiac Myocyte Na\n            <sup>+<\/sup>\n            -K\n            <sup>+<\/sup>\n            Pump Function With \u03b23 Adrenergic Agonist in Rabbit Model of Severe Congestive Heart Failure"],"prefix":"10.1161","volume":"13","author":[{"given":"Natasha A.S.","family":"Fry","sequence":"first","affiliation":[{"name":"North Shore Heart Research Group, Kolling Medical Research Institute, University of Sydney, Australia (N.A.S.F., E.J.H., Y.J.K., H.H.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Chi","family":"Liu","sequence":"additional","affiliation":[{"name":"University of Sydney, Australia (C.-C.L., K.K.G., Y.J.K., D.W.W., H.H.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Garcia","sequence":"additional","affiliation":[{"name":"University of Technology Sydney, Australia (A.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisha J.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"North Shore Heart Research Group, Kolling Medical Research Institute, University of Sydney, Australia (N.A.S.F., E.J.H., Y.J.K., H.H.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyvan","family":"Karimi Galougahi","sequence":"additional","affiliation":[{"name":"University of Sydney, Australia (C.-C.L., K.K.G., Y.J.K., D.W.W., H.H.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"North Shore Heart Research Group, Kolling Medical Research Institute, University of Sydney, Australia (N.A.S.F., E.J.H., Y.J.K., H.H.R.)."},{"name":"University of Sydney, Australia (C.-C.L., K.K.G., Y.J.K., D.W.W., H.H.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Whalley","sequence":"additional","affiliation":[{"name":"University of Sydney, Australia (C.-C.L., K.K.G., Y.J.K., D.W.W., H.H.R.)."},{"name":"Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (D.W.W., H.H.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Bundgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Denmark (H.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2409-4083","authenticated-orcid":true,"given":"Helge H.","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"North Shore Heart Research Group, Kolling Medical Research Institute, University of Sydney, Australia (N.A.S.F., E.J.H., Y.J.K., H.H.R.)."},{"name":"University of Sydney, Australia (C.-C.L., K.K.G., Y.J.K., D.W.W., H.H.R.)."},{"name":"Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (D.W.W., 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