{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:05:32Z","timestamp":1793127932123,"version":"4.5.0"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>\u03b2-Blockers (BBs) are mainstay therapy for heart failure with reduced ejection fraction. However, individual patient responses to BB vary, which may be partially due to genetic variation. The goal of this study was to derive and validate the first polygenic response predictor (PRP) for BB survival benefit in heart failure with reduced ejection fraction patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Derivation and validation analyses were performed in n=1436 total HF patients of European descent and with ejection fraction &lt;50%. The PRP was derived in a random subset of the Henry Ford Heart Failure Pharmacogenomic Registry (n=248) and then validated in a meta-analysis of the remaining patients from Henry Ford Heart Failure Pharmacogenomic Registry (n=247), the TIME-CHF (Trial of Intensified Versus Standard Medical Therapy in Elderly Patients With Congestive Heart Failure; n=431), and HF-ACTION trial (Heart Failure: a Controlled Trial Investigating Outcomes of Exercise Training; n=510). The PRP was constructed from a genome-wide analysis of BB\u00d7genotype interaction predicting time to all-cause mortality, adjusted for Meta-Analysis Global Group in Chronic Heart Failure score, genotype, level of BB exposure, and BB propensity score.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Five-fold cross-validation summaries out to 1000 single-nucleotide polymorphisms identified optimal prediction with a 44 single-nucleotide polymorphism score and cutoff at the 30th percentile. In validation testing (n=1188), greater BB exposure was associated with reduced all-cause mortality in patients with low PRP score (n=251; hazard ratio, 0.19 [95% CI, 0.04\u20130.51];\n              <jats:italic>P<\/jats:italic>\n              =0.0075) but not high PRP score (n=937; hazard ratio, 0.84 [95% CI, 0.53\u20131.3];\n              <jats:italic>P<\/jats:italic>\n              =0.448)\u2014a difference that was statistically significant (\n              <jats:italic>P<\/jats:italic>\n              interaction, 0.0235). Results were consistent regardless of atrial fibrillation, ejection fraction (\u226440% versus 41%\u201350%), or when examining cardiovascular death.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Among patients of European ancestry with heart failure with reduced ejection fraction, a PRP distinguished patients who derived substantial survival benefit from BB exposure from a larger group that did not. Additional work is needed to prospectively test clinical utility and to develop PRPs for other population groups and other medications.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.119.007012","type":"journal-article","created":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T09:00:12Z","timestamp":1601802012000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Polygenic Score for \u03b2-Blocker Survival Benefit in European Ancestry Patients With Reduced Ejection Fraction Heart Failure"],"prefix":"10.1161","volume":"13","author":[{"given":"David E.","family":"Lanfear","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Center for Individualized and Genomic Medicine Research (D.E.L., J.A.L., R.S., H.G., N.Z., J.L., L.K.W.), Henry Ford Hospital, Detroit, MI."},{"name":"Heart and Vascular Institute (D.E.L., H.N.S., J.L.), Henry Ford Hospital, Detroit, MI."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine A.","family":"Luzum","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center for Individualized and Genomic Medicine Research (D.E.L., J.A.L., R.S., H.G., N.Z., J.L., L.K.W.), Henry Ford Hospital, Detroit, MI."},{"name":"Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor (J.A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruicong","family":"She","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center for Individualized and Genomic Medicine Research (D.E.L., J.A.L., R.S., H.G., N.Z., J.L., L.K.W.), Henry Ford Hospital, Detroit, MI."},{"name":"Department of Public Health Sciences (R.S.), Henry Ford Hospital, Detroit, MI."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center for Individualized and Genomic Medicine Research (D.E.L., J.A.L., R.S., H.G., N.Z., J.L., L.K.W.), Henry Ford Hospital, Detroit, MI."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Donahue","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Duke University, Durham, NC (M.P.D., W.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"Inova Heart and Vascular Institute, Falls Church, VA (C.M.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirkwood F.","family":"Adams","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of North Carolina, Chapel Hill (K.F.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Sanders-van Wijk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Maastricht University, the Netherlands (S.S.-v.W., H.-P.B.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Zeld","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center for Individualized and Genomic Medicine Research (D.E.L., J.A.L., R.S., H.G., N.Z., J.L., L.K.W.), Henry Ford Hospital, Detroit, MI."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha T.","family":"Maeder","sequence":"additional","affiliation":[{"name":"Cardiology Department, Kantonsspital St. Gallen, Switzerland (M.T.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani N.","family":"Sabbah","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute (D.E.L., H.N.S., J.L.), Henry Ford Hospital, Detroit, MI."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Kraus","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Duke University, Durham, NC (M.P.D., W.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Brunner-LaRocca","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Maastricht University, the Netherlands (S.S.-v.W., H.-P.B.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center for Individualized and Genomic Medicine Research (D.E.L., J.A.L., R.S., H.G., N.Z., J.L., L.K.W.), Henry Ford Hospital, Detroit, MI."},{"name":"Heart and Vascular Institute (D.E.L., H.N.S., J.L.), Henry Ford Hospital, Detroit, MI."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7592-5791","authenticated-orcid":true,"given":"L. 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