{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:35:35Z","timestamp":1794000935646,"version":"4.8.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Risk stratifying patients with cardiogenic shock (CS) is a major unmet need. The recently proposed Society for Cardiovascular Angiography and Interventions (SCAI) stages as an approach to identify patients at risk for in-hospital mortality remains under investigation. We studied the utility of the SCAI stages and further explored the impact of hemodynamic congestion on clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The CS Working Group registry includes patients with CS from 8 medical centers enrolled between 2016 and 2019. Patients were classified by the maximum SCAI stage (B\u2013E) reached during their hospital stay according to drug and device utilization. In-hospital mortality was evaluated for association with SCAI stages and hemodynamic congestion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the 1414 patients with CS, the majority were due to decompensated heart failure (50%) or myocardial infarction (MI; 35%). In-hospital mortality was 31% for the total cohort, but higher among patients with MI (41% versus 26%, MI versus heart failure,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001). Risk for in-hospital mortality was associated with increasing SCAI stage (odds ratio [95% CI], 3.25 [2.63\u20134.02]) in both MI and heart failure cohorts. Hemodynamic data was available in 1116 (79%) patients. Elevated biventricular filling pressures were common among patients with CS, and right atrial pressure was associated with increased mortality and higher SCAI Stage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our findings support an association between the proposed SCAI staging system and in-hospital mortality among patient with heart failure and MI. We further identify that venous congestion is common and identifies patients with CS at high risk for in-hospital mortality. These findings provide may inform future management protocols and clinical studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circheartfailure.120.007099","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T05:04:58Z","timestamp":1599627898000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":309,"title":["Invasive Hemodynamic Assessment and Classification of In-Hospital Mortality Risk Among Patients With Cardiogenic Shock"],"prefix":"10.1161","volume":"13","author":[{"given":"Katherine L.","family":"Thayer","sequence":"first","affiliation":[{"name":"The CardioVascular Center, Tufts Medical Center, Boston, MA (K.L.T., E.Z., K.J.M., S.N., J.L.H., N.M.H., M.L.E., C.D.D., J.U., N.K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elric","family":"Zweck","sequence":"additional","affiliation":[{"name":"The CardioVascular Center, Tufts Medical Center, Boston, MA (K.L.T., E.Z., K.J.M., S.N., J.L.H., N.M.H., M.L.E., C.D.D., J.U., N.K.K.)."},{"name":"Medical Faculty, Heinrich Heine University, D\u00fcsseldorf, Germany (E.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohyee","family":"Ayouty","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine, Boston, MA (M.A., L.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7510-075X","authenticated-orcid":true,"given":"A. Reshad","family":"Garan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA (A.R.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Hernandez-Montfort","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Florida, Department of Cardiovascular Medicine Weston (J.H.-M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudius","family":"Mahr","sequence":"additional","affiliation":[{"name":"Heart Institute at University of Washington Medical Center, Seattle (C.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Morine","sequence":"additional","affiliation":[{"name":"The CardioVascular Center, Tufts Medical Center, Boston, MA (K.L.T., E.Z., K.J.M., S.N., J.L.H., N.M.H., M.L.E., C.D.D., J.U., N.K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Newman","sequence":"additional","affiliation":[{"name":"The CardioVascular Center, Tufts Medical Center, Boston, MA (K.L.T., E.Z., K.J.M., S.N., J.L.H., N.M.H., M.L.E., C.D.D., J.U., N.K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Jorde","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine, Boston, MA (M.A., L.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian L.","family":"Haywood","sequence":"additional","affiliation":[{"name":"The CardioVascular Center, Tufts Medical Center, Boston, MA (K.L.T., E.Z., K.J.M., S.N., J.L.H., N.M.H., M.L.E., C.D.D., J.U., N.K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil M.","family":"Harwani","sequence":"additional","affiliation":[{"name":"The CardioVascular Center, Tufts Medical Center, Boston, MA (K.L.T., E.Z., K.J.M., S.N., J.L.H., N.M.H., M.L.E., C.D.D., J.U., N.K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele L.","family":"Esposito","sequence":"additional","affiliation":[{"name":"The CardioVascular Center, Tufts Medical Center, Boston, MA (K.L.T., E.Z., K.J.M., S.N., J.L.H., N.M.H., M.L.E., C.D.D., J.U., N.K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos D.","family":"Davila","sequence":"additional","affiliation":[{"name":"The CardioVascular Center, Tufts Medical Center, Boston, MA (K.L.T., E.Z., K.J.M., S.N., J.L.H., N.M.H., M.L.E., C.D.D., J.U., N.K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef","family":"Wencker","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Advanced Heart Failure Clinic, Dallas, TX (D.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashank S.","family":"Sinha","sequence":"additional","affiliation":[{"name":"Inova Heart and Vascular Institute, Falls Church, VA (S.S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Vorovich","sequence":"additional","affiliation":[{"name":"Bluhm Cardiovascular Institute of Northwestern Medicine, Chicago, IL (E.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Abraham","sequence":"additional","affiliation":[{"name":"Providence Heart Institute, Portland, OR (J.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"Center for Structural Heart Disease at Henry Ford Hospital, Detroit, MI (W.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Udelson","sequence":"additional","affiliation":[{"name":"The CardioVascular Center, Tufts Medical Center, Boston, MA (K.L.T., E.Z., K.J.M., S.N., J.L.H., N.M.H., M.L.E., C.D.D., J.U., N.K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3995-2466","authenticated-orcid":true,"given":"Daniel","family":"Burkhoff","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation, NY (D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8302-6796","authenticated-orcid":true,"given":"Navin K.","family":"Kapur","sequence":"additional","affiliation":[{"name":"The CardioVascular Center, Tufts Medical Center, Boston, MA (K.L.T., E.Z., K.J.M., S.N., J.L.H., N.M.H., M.L.E., C.D.D., J.U., N.K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000590"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000525"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.115.002359"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036691"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208410"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908263410901"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.10.022"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/HHF.0b013e318291329a"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-17-00947"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.07.958"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28329"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.07.077"},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","unstructured":"SchrageB Dabboura S Yan I Hilal R Neumann JT Sorensen NA Gossling A Becher PM Grahn H Wagner T et al. 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