{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:27:44Z","timestamp":1785425264022,"version":"3.56.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>There are limited data on how sex influences the outcomes of acute myocardial infarction-cardiogenic shock (AMI-CS) in young adults.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>A retrospective cohort of AMI-CS admissions aged 18 to 55 years, during 2000 to 2017, was identified using the National Inpatient Sample. Use of coronary angiography, percutaneous coronary intervention, mechanical circulatory support and noncardiac interventions was identified. Outcomes of interest included in-hospital mortality, use of cardiac interventions, hospitalization costs, and length of stay.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              A total 90\u2009648 AMI-CS admissions \u226455 years of age were included, of which 26% were women. Higher rates of CS were noted in men (2.2% in 2000 to 4.8% in 2017) compared with women (2.6% in 2000 to 4.0% in 2017;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Compared with men, women with AMI-CS were more frequently of Black race, from a lower socioeconomic status, with higher comorbidity, and admitted to rural and small hospitals (all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Women had lower rates of ST-segment elevation presentation (73.0% versus 78.7%), acute noncardiac organ failure, cardiac arrest (34.3% versus 35.7%), and received less-frequent coronary angiography (78.3% versus 81.4%), early coronary angiography (49.2% versus 54.1%), percutaneous coronary intervention (59.2% versus 64.0%), and mechanical circulatory support (50.3% versus 59.2%; all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Female sex was an independent predictor of in-hospital mortality (23.0% versus 21.7%; adjusted odds ratio, 1.11 [95% CI, 1.07\u20131.16];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Women had lower hospitalization costs ($156\u2009372\u00b1$198\u2009452 versus $167\u2009669\u00b1$208\u2009577;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) but comparable lengths of stay compared with men.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>In young AMI-CS admissions, women are treated less aggressively and experience higher in-hospital mortality than men.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.120.007154","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T09:00:20Z","timestamp":1601370020000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":118,"title":["Sex Disparities in the Management and Outcomes of Cardiogenic Shock Complicating Acute Myocardial Infarction in the Young"],"prefix":"10.1161","volume":"13","author":[{"given":"Saraschandra","family":"Vallabhajosyula","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine (S.V., M.S., M.R.B., R.G., A.S.J., B.J.G., D.R.H., G.W.B.), Mayo Mayo Clinic, Rochester, MN."},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine (S.V.), Mayo Mayo Clinic, Rochester, MN."},{"name":"Center for Clinical and Translational Science, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN (S.V.)."},{"name":"Section of Interventional Cardiology, Division of Cardiovascular Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA (S.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Ya\u2019Qoub","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Louisiana State University School of Medicine, Shreveport (L.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (S.V., M.S., M.R.B., R.G., A.S.J., B.J.G., D.R.H., G.W.B.), Mayo Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm R.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (S.V., M.S., M.R.B., R.G., A.S.J., B.J.G., D.R.H., G.W.B.), Mayo Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2713-0433","authenticated-orcid":true,"given":"Rajiv","family":"Gulati","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (S.V., M.S., M.R.B., R.G., A.S.J., B.J.G., D.R.H., G.W.B.), Mayo Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9954-9711","authenticated-orcid":true,"given":"Wisit","family":"Cheungpasitporn","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, University of Mississippi School of Medicine, Jackson (W.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranathi R.","family":"Sundaragiri","sequence":"additional","affiliation":[{"name":"Division of Hospital Internal Medicine, Department of Medicine (P.R.S.), Mayo Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia M.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biomedical Engineering (V.M.M.), Mayo Mayo Clinic, Rochester, MN."},{"name":"Department of Surgery (V.M.M.), Mayo Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1183-3959","authenticated-orcid":true,"given":"Allan S.","family":"Jaffe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (S.V., M.S., M.R.B., R.G., A.S.J., B.J.G., D.R.H., G.W.B.), Mayo Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5605-900X","authenticated-orcid":true,"given":"Bernard J.","family":"Gersh","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (S.V., M.S., M.R.B., R.G., A.S.J., B.J.G., D.R.H., G.W.B.), Mayo Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0037-0373","authenticated-orcid":true,"suffix":"Jr","given":"David R.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (S.V., M.S., M.R.B., R.G., A.S.J., B.J.G., D.R.H., G.W.B.), Mayo Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6353-6780","authenticated-orcid":true,"given":"Gregory W.","family":"Barsness","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (S.V., M.S., M.R.B., R.G., A.S.J., B.J.G., D.R.H., G.W.B.), Mayo Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.05.038"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.03.008"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.01.053"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.02.033"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006661"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.011954"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000075927.67673.F2"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0222894"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-019-0571-2"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.12.007"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.01.043"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12482"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12298"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000351"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.15420\/icr.2019.09"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007021"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.031650"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.115.002482"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.11.096"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.05.001"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-014-0767-2"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(01)01581-9"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.001995"},{"key":"e_1_3_5_25_2","unstructured":"Introduction to the HCUP Nationwide Inpatient Sample 2009. http:\/\/www.hcup-us.ahrq.gov\/db\/nation\/nis\/NIS_2009_INTRODUCTION.pdf. Accessed January 18 2015."},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000182534.19832.83"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.09.001"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010193"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102104"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009160"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001039"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2019.100414"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.005929"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-00226"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40119-019-00152-8"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28543"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2019.11.007"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.10.029"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.12.007"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.117.003846"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17653"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.008537"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.006062"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.054"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.06.033"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-002862"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2011.10.005"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.02.031"}],"container-title":["Circulation: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCHEARTFAILURE.120.007154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:32:39Z","timestamp":1715563959000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCHEARTFAILURE.120.007154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1161\/CIRCHEARTFAILURE.120.007154"],"URL":"https:\/\/doi.org\/10.1161\/circheartfailure.120.007154","relation":{},"ISSN":["1941-3289","1941-3297"],"issn-type":[{"value":"1941-3289","type":"print"},{"value":"1941-3297","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"2020-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}