{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:31:39Z","timestamp":1768012299513,"version":"3.49.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Heart failure with preserved ejection fraction is increasing in prevalence, but few effective treatments are available. Elevated left ventricular (LV) diastolic filling pressures represent a key therapeutic target. Pericardial restraint contributes to elevated LV end-diastolic pressure, and acute studies have shown that pericardiotomy attenuates the rise in LV end-diastolic pressure with volume loading. However, whether these acute effects are sustained chronically remains unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Minimally invasive pericardiotomy was performed percutaneously using a novel device in a porcine model of heart failure with preserved ejection fraction. Hemodynamics were assessed at baseline and following volume loading with pericardium intact, acutely following pericardiotomy, and then again chronically after 4 weeks. Cardiac structure was assessed by magnetic resonance imaging.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              The increase in LV end-diastolic pressure with volume loading was mitigated by 41% (95% CI, 27%\u201345%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001; \u0394LV end-diastolic pressure reduced from +9\u00b13 mm\u2009Hg to +5\u00b13 mm\u2009Hg,\n              <jats:italic>P<\/jats:italic>\n              =0.0003, 95% CI, \u22122.2 to \u22125.5). The effect was sustained at 4 weeks (+5\u00b12 mm\u2009Hg,\n              <jats:italic>P<\/jats:italic>\n              =0.28 versus acute). There was no statistically significant effect of pericardiotomy on ventricular remodeling compared with age-matched controls. None of the animals developed hemodynamic or pathological indicators of pericardial constriction or frank systolic dysfunction.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The acute hemodynamic benefits of pericardiotomy are sustained for at least 4 weeks in a swine model of heart failure with preserved ejection fraction, without excessive chamber remodeling, pericarditis, or clinically significant systolic dysfunction. These data support trials evaluating minimally invasive pericardiotomy as a novel treatment for heart failure with preserved ejection fraction in humans.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.120.007530","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T10:07:35Z","timestamp":1611310055000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Sustained Improvement in Diastolic Reserve Following Percutaneous Pericardiotomy in a Porcine Model of Heart Failure With Preserved Ejection Fraction"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1116-8541","authenticated-orcid":true,"given":"C. Charles","family":"Jain","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine (C.C.J., A.S., V.R.V., D. Padmanabhan, S.J.A., B.A.B.), Mayo Clinic Rochester, MN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn","family":"Pedrotty","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Mayo Clinic Arizona (D. Pedrotty)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5465-7997","authenticated-orcid":true,"given":"Philip A.","family":"Araoz","sequence":"additional","affiliation":[{"name":"Department of Radiology (P.A.A., S.P.A.), Mayo Clinic Rochester, MN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9921-6968","authenticated-orcid":true,"given":"Alan","family":"Sugrue","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (C.C.J., A.S., V.R.V., D. Padmanabhan, S.J.A., B.A.B.), Mayo Clinic Rochester, MN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1422-7321","authenticated-orcid":true,"given":"Vaibhav R.","family":"Vaidya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (C.C.J., A.S., V.R.V., D. Padmanabhan, S.J.A., B.A.B.), Mayo Clinic Rochester, MN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9127-9275","authenticated-orcid":true,"given":"Deepak","family":"Padmanabhan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (C.C.J., A.S., V.R.V., D. Padmanabhan, S.J.A., B.A.B.), Mayo Clinic Rochester, MN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3251-5415","authenticated-orcid":true,"given":"Shivaram P.","family":"Arunachalam","sequence":"additional","affiliation":[{"name":"Department of Radiology (P.A.A., S.P.A.), Mayo Clinic Rochester, MN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3271-3887","authenticated-orcid":true,"given":"Lilach O.","family":"Lerman","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension (L.O.L.), Mayo Clinic Rochester, MN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9835-5536","authenticated-orcid":true,"given":"Samuel J.","family":"Asirvatham","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (C.C.J., A.S., V.R.V., D. 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