{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T17:07:37Z","timestamp":1788196057090,"version":"build-2803163510"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>The association of obesity on outcomes in patients with cardiogenic shock requiring acute mechanical circulatory support has not been thoroughly investigated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              We evaluated the National Readmission Database for adults with either acute myocardial infarction or heart failure complicated by cardiogenic shock requiring acute mechanical circulatory support between January 2016 and November 2017. Exposure was assessed using\n              <jats:italic>International Classification of Diseases<\/jats:italic>\n              ,\n              <jats:italic>Tenth Revision<\/jats:italic>\n              codes for the degree of obesity with the reference being body mass index (BMI) of 20.0 to 29.9 group. Multiple logistic regression and Cox regression analysis were used to analyze in-hospital mortality and 30-day readmission, respectively.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              The survey-weighted sample included a total of 35\u2009555 hospitalizations with a mean age of 65.4\u00b10.2 years and 29.8% females. Obesity was associated with higher in-hospital mortality (no obesity, 26.4% [BMI, 20.0\u201329.9] versus class I obesity, 25.0% [BMI, 30.0\u201334.9] versus class II obesity, 28.7% [BMI, 35.0\u201339.9] versus class III obesity, 34.9% [BMI, \u226540];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). On stratified analysis, compared with a nonobese phenotype, younger adults (age &lt;60) with class II and class III obesity (odds ratio, 1.9 [95% CI, 1.1\u20133.5],\n              <jats:italic>P<\/jats:italic>\n              =0.02; odds ratio, 2.1 [95% CI, 1.2\u20133.7],\n              <jats:italic>P<\/jats:italic>\n              =0.01) and older adults (age \u226560) with class III obesity (odds ratio, 1.7 [95% CI, 1.2\u20132.4],\n              <jats:italic>P<\/jats:italic>\n              =0.005) had higher mortality. There was no association between the degree of obesity and 30-day readmission.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Among adults with acute myocardial infarction or acute heart failure resulting in cardiogenic shock requiring acute mechanical circulatory support, younger adults with class II and class III obesity and older patients with class III obesity have a higher risk of in-hospital mortality compared with nonobese patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.120.007937","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T10:00:31Z","timestamp":1615543231000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Obesity and Outcomes Following Cardiogenic Shock Requiring Acute Mechanical Circulatory Support"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2065-4119","authenticated-orcid":true,"given":"Jayakumar","family":"Sreenivasan","sequence":"first","affiliation":[{"name":"Department of Cardiology, Westchester Medical Center and New York Medical College, Valhalla, NY (J.S., P.S., U.H., H.A., G.M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1250-6351","authenticated-orcid":true,"given":"Muhammad Shahzeb","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cook County Health, Chicago, IL (M.S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9778-7046","authenticated-orcid":true,"given":"Parija","family":"Sharedalal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Westchester Medical Center and New York Medical College, Valhalla, NY (J.S., P.S., U.H., H.A., G.M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urvashi","family":"Hooda","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Westchester Medical Center and New York Medical College, Valhalla, NY (J.S., P.S., U.H., H.A., G.M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8671-7007","authenticated-orcid":true,"given":"Marat","family":"Fudim","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC (M.F.)."},{"name":"Division of Cardiology, Duke University Medical Center, Durham, NC, (M.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3429-0379","authenticated-orcid":true,"given":"Ryan T.","family":"Demmer","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (R.T.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melana","family":"Yuzefpolskaya","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, NY (M.Y., P.C.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7807-3398","authenticated-orcid":true,"given":"Hasan","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Westchester Medical Center and New York Medical College, Valhalla, NY (J.S., P.S., U.H., H.A., G.M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0643-1859","authenticated-orcid":true,"given":"Sadiya S.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL (S.S.K., J.D.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8750-601X","authenticated-orcid":true,"given":"Gregg M.","family":"Lanier","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Westchester Medical Center and New York Medical College, Valhalla, NY (J.S., P.S., U.H., H.A., G.M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo C.","family":"Colombo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, NY (M.Y., P.C.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2370-5252","authenticated-orcid":true,"given":"Jonathan D.","family":"Rich","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL (S.S.K., 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