{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T17:47:48Z","timestamp":1769104068037,"version":"3.49.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>The coronavirus disease 2019 (COVID-19) pandemic continues to afflict millions of people worldwide. Patients with end-stage heart failure and left ventricular assist devices (LVADs) may be at risk for severe COVID-19 given a high prevalence of complex comorbidities and functional impaired immunity. The objective of this study is to describe the clinical characteristics and outcomes of COVID-19 in patients with end-stage heart failure and durable LVADs.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>The Trans-CoV-VAD registry is a multi-center registry of LVAD and cardiac transplant patients in the United States with confirmed COVID-19. Patient characteristics, exposure history, presentation, laboratory data, course, and clinical outcomes were collected by participating institutions and reviewed by a central data repository. This report represents the participation of the first 9 centers to report LVAD data into the registry.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>A total of 40 patients were included in this cohort. The median age was 56 years (interquartile range, 46\u201368), 14 (35%) were women, and 21 (52%) were Black. Among the most common presenting symptoms were cough (41%), fever, and fatigue (both 38%). A total of 18% were asymptomatic at diagnosis. Only 43% of the patients reported either subjective or measured fever during the entire course of illness. Over half (60%) required hospitalization, and 8 patients (20%) died, often after lengthy hospitalizations.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>We present the largest case series of LVAD patients with COVID-19 to date. Understanding these characteristics is essential in an effort to improve the outcome of this complex patient population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.120.007957","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T09:00:57Z","timestamp":1617613257000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Characteristics and Outcomes of COVID-19 in Patients on Left Ventricular Assist Device Support"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7933-7794","authenticated-orcid":true,"given":"Edo Y.","family":"Birati","sequence":"first","affiliation":[{"name":"Cardiovascular Division, Department of Medicine (E.Y.B., K.U., M.M., S.C., N.E., K.B.M., T.C.H., R.Z., J.W.W., J.A.M., A.T.O., L.R.G., M.V.G.), University of Pennsylvania, Philadelphia."},{"name":"Perelman School of Medicine and Cardiovascular Outcomes, Quality, and Evaluative Research Center (E.Y.B.), University of Pennsylvania, Philadelphia."},{"name":"Cardiovascular Division, Poriya Medical Center, Bar-Ilan University, Israel. (E.Y.B.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9149-416X","authenticated-orcid":true,"given":"Samer S.","family":"Najjar","sequence":"additional","affiliation":[{"name":"MedStar Washington Hospital Center, Washington, DC (S.S.N.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9045-7722","authenticated-orcid":true,"given":"Ryan J.","family":"Tedford","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina, Charleston, SC (R.J.T., B.A.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6188-8072","authenticated-orcid":true,"given":"Brian A.","family":"Houston","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina, Charleston, SC (R.J.T., B.A.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5436-6097","authenticated-orcid":true,"given":"Supriya","family":"Shore","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, University of Michigan, Ann Arbor (S.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6810-3311","authenticated-orcid":true,"given":"Esther","family":"Vorovich","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Northwestern University, Chicago, IL (E.V.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavan","family":"Atluri","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery (P.A.), University of Pennsylvania, 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