{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:55:21Z","timestamp":1793084121349,"version":"4.5.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Prior studies of structural and electrocardiographic changes in arrhythmogenic right ventricular (RV) cardiomyopathy and their role in predicting ventricular arrhythmias (ventricular tachycardia) have shown conflicting results.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We reviewed 405 ECGs, 315 transthoracic echocardiographies, and 441 implantable cardioverter defibrillator interrogations in 64 arrhythmogenic RV cardiomyopathy patients (56% men, mean age [SD], 44.2 [14.6] years) over a mean follow-up of 10 (range, 2.3\u201319) years. Generalized estimating equations were used to identify the association between ECG abnormalities, clinical variables, and transthoracic echocardiographic measurements (&gt;mild degree of tricuspid regurgitation, RV outflow tract diameter in parasternal long axis and short axis, RV end-diastolic area, fractional area change).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>There was a 4.65 (95% CI, 0.51%\u20138.8%) increase in RV end-diastolic area, a 3.75 (95% CI, 1.17%\u20136.34%) decrease in fractional area change, and 1.9 (95% CI, 1.3\u20132.8) higher odds (odds ratio) of RV wall motion abnormality with every 5-year increase in age after patients\u2019 first transthoracic echocardiography. &gt;Mild tricuspid regurgitation was an independent predictor of RV enlargement and dysfunction (hazard ratio of &gt;10% drop in fractional area change from baseline [95% CI], 3.51 [1.77\u20136.95] and hazard ratio of &gt;10% increase in RV end-diastolic area from baseline [95% CI], 4.90 [2.52\u20139.52]). Patients with implantable cardioverter defibrillator were more likely to develop &gt;mild tricuspid regurgitation and larger structural and functional disease progression. More pronounced increase in RV end-diastolic area was translated into higher rates of any ventricular tachycardia. Inferior T-wave inversions and sum of R waves (mm) in V1 to V3 were predictors of RV enlargement and dysfunction with the former also predicting risk of any ventricular tachycardia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Arrhythmogenic RV cardiomyopathy is a progressive disease. Tricuspid regurgitation is an independent predictor of structural disease progression, which may be exacerbated by use of a transvenous implantable cardioverter defibrillator lead.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.120.008121","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T09:00:37Z","timestamp":1631610037000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Long-Term Electrocardiographic and Echocardiographic Progression of Arrhythmogenic Right Ventricular Cardiomyopathy and Their Correlation With Ventricular Tachyarrhythmias"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2996-0836","authenticated-orcid":true,"given":"Shadi","family":"Kalantarian","sequence":"first","affiliation":[{"name":"University of California San Francisco (S.K., S.S., E.V., L.K., M.M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2693-0949","authenticated-orcid":true,"given":"Meriam","family":"\u00c5str\u00f6m Aneq","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Department of Health, Medicine and Caring Sciences, Link\u00f6ping University, Sweden (M.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Svetlichnaya","sequence":"additional","affiliation":[{"name":"Kaiser Permanente, San Francisco, CA (J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha","family":"Sharma","sequence":"additional","affiliation":[{"name":"University of California San Francisco (S.K., S.S., E.V., L.K., M.M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8535-0920","authenticated-orcid":true,"given":"Eric","family":"Vittinghoff","sequence":"additional","affiliation":[{"name":"University of California San Francisco (S.K., S.S., E.V., L.K., M.M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0547-1480","authenticated-orcid":true,"given":"Liviu","family":"Klein","sequence":"additional","affiliation":[{"name":"University of California San Francisco (S.K., S.S., E.V., L.K., M.M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6295-3753","authenticated-orcid":true,"given":"Melvin M.","family":"Scheinman","sequence":"additional","affiliation":[{"name":"University of California San Francisco (S.K., S.S., E.V., L.K., M.M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1509267"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.276.3.199"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.840827"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.01.017"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.02.031"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/2048872612453922"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.838821"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000142293.60725.18"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12246"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.05.010"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.01.007"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.2307\/2531734"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3462-1"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/80.15.1198"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000103130.33451.D2"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3294-8"},{"key":"e_1_3_6_18_2","volume-title":"Seemingly Unrelated Estimation and the Cluster-Adjusted Sandwich Estimator","author":"Weesie J","year":"1999","unstructured":"Weesie, J. Seemingly Unrelated Estimation and the Cluster-Adjusted Sandwich Estimator. Stata Press; 1999."},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.5034"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14069"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008782"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.007611"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.311"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000143375.93288.82"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(97)00332-x"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12947"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.11.055"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx011"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.06.033"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-15-4"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90511-s"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.116.003819"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.4137\/CMC.S18770"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(00)00997-9"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.035"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017944"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.12.010"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.08.031"}],"container-title":["Circulation: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCHEARTFAILURE.120.008121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:17:50Z","timestamp":1715563070000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCHEARTFAILURE.120.008121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1161\/CIRCHEARTFAILURE.120.008121"],"URL":"https:\/\/doi.org\/10.1161\/circheartfailure.120.008121","relation":{},"ISSN":["1941-3289","1941-3297"],"issn-type":[{"value":"1941-3289","type":"print"},{"value":"1941-3297","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"2020-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}