{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:40:20Z","timestamp":1793814020365,"version":"4.6.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>There has been increasing use of extracorporeal membrane oxygenation (ECMO) as bridge to heart transplant (orthotopic heart transplant [OHT]) or left ventricular assist device (LVAD) over the last decade. We aimed to provide insights on the population, outcomes, and predictors for the selection of each therapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Using the Extracorporeal Life Support Organization Registry between 2010 and 2019, we compared in-hospital mortality and length of stay, predictors of OHT versus LVAD, and predictors of in-hospital mortality for patients with cardiogenic shock that were bridged with ECMO to OHT or LVAD. One hundred sixty-seven patients underwent LVAD versus 234 patients who underwent OHT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              The overall use of ECMO has increased from 1.7% in 2010 to 22.2% in 2019. Mortality was similar between groups (LVAD: 28.7% versus OHT: 29.1%) while length of stay was longer for OHT (LVAD: 49.6 versus OHT: 59.5 days,\n              <jats:italic>P<\/jats:italic>\n              =0.05). Factors associated with OHT included prior transplant (odds ratio [OR]=31.26 [CI, 3.84\u2013780.5]), use of a temporary pacemaker (OR=6.5 [CI, 1.39\u201350.15]), and increased use of inotropes on ECMO (OR=3.77 [CI, 1.39\u201311.07]), whereas LVAD use was associated with weight (OR=0.98 [CI, 0.97\u20130.99]), cardiogenic shock presentation (OR=0.40 [CI, 0.21\u20130.78]), previous LVAD (OR=0.01 [CI, 0.0001\u20130.22]), respiratory failure (OR=0.28 [CI, 0.11\u20130.70]), and milrinone infusion (OR=0.32 [CI, 0.15\u20130.67]). Older age (OR=1.07 [CI, 1.02\u20131.12]), cannulation bleeding (OR=26.1 [CI, 4.32\u2013221.3]), and surgical bleeding (OR=6.7 [CI, 1.26\u201339.9]) in patients receiving LVAD and respiratory failure (OR=5 [CI, 1.17\u201323.1]) and continuous renal replacement therapy (OR=3.82 [CI, 1.28\u201311.9]) in patients receiving OHT were associated with increased mortality.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>ECMO use as a bridge to advanced therapies has increased over time, with more patients undergoing LVAD than OHT. Mortality was equal between the 2 groups while length of stay was longer for OHT.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.121.008777","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T10:01:36Z","timestamp":1639044096000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Use of Extracorporeal Membrane Oxygenation as Bridge to Replacement Therapies in Cardiogenic Shock: Insights From the Extracorporeal Life Support Organization"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1779-6629","authenticated-orcid":true,"given":"Ioannis","family":"Mastoris","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine (I.M., A.J.S., N.A.H., Z.S.), University of Kansas Health System, University of Kansas School of Medicine, Kansas City."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8879-2628","authenticated-orcid":true,"given":"Joseph E.","family":"Tonna","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery (J.E.T.), Department of Surgery, University of Utah Health, Salt Lake City."},{"name":"Division of Emergency Medicine (J.E.T.), Department of Surgery, University of Utah Health, Salt Lake City."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics (J.H., Y.W.), University of Kansas Health System, University of Kansas School of Medicine, Kansas City."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Sauer","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (I.M., A.J.S., N.A.H., Z.S.), University of Kansas Health System, University of Kansas School of Medicine, Kansas City."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A.","family":"Haglund","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (I.M., A.J.S., N.A.H., Z.S.), University of Kansas Health System, University of Kansas School of Medicine, Kansas City."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7098-651X","authenticated-orcid":true,"given":"Peter","family":"Rycus","sequence":"additional","affiliation":[{"name":"Extracorporeal Life Support Organization, Ann Arbor, MI (P.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8780-1342","authenticated-orcid":true,"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics (J.H., Y.W.), University of Kansas Health System, University of Kansas School of Medicine, Kansas City."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3045-245X","authenticated-orcid":true,"given":"William J.","family":"Wallisch","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology (W.J.W.), University of Kansas Health System, University of Kansas School of Medicine, Kansas City."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6112-6331","authenticated-orcid":true,"given":"Travis O.","family":"Abicht","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery (T.O.A., M.R.D.), University of Kansas Health System, University of Kansas School of Medicine, Kansas City."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Danter","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery (T.O.A., M.R.D.), University of Kansas Health System, University of Kansas School of Medicine, Kansas City."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9045-7722","authenticated-orcid":true,"given":"Ryan J.","family":"Tedford","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston (R.J.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2427-9504","authenticated-orcid":true,"given":"James C.","family":"Fang","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Utah, Salt Lake City (J.C.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3221-3655","authenticated-orcid":true,"given":"Zubair","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (I.M., A.J.S., N.A.H., Z.S.), University of Kansas Health System, University of Kansas School of Medicine, Kansas City."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.11.038"},{"key":"e_1_3_2_3_2","unstructured":"The Extracorporeal Life Support Organization (ELSO). Accessed November 25 2020. www.elso.org."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2017.11.017"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.04.003"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.100.suppl_2.ii-206"},{"key":"e_1_3_2_7_2","volume-title":"ECMO Registry of the Extracorporeal Life Support Organization (ELSO)","year":"2021","unstructured":"ECMO Registry of the Extracorporeal Life Support Organization (ELSO). Ann Arbor, Michigan. February, 2021."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32008-0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1996.tb02080.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2014.09.005"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019143"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.03.120"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2015.11.013"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.120.007924"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000590"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.04.037"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.03.283"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.08.072"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2018.04.299"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-05939-1"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.15118"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.04.008"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.07.012"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006387"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.959254"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.02.094"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.01.008"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000035"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.10.036"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.12.011"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezy351"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2020.100509"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2018.07.404"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2020.08.012"}],"container-title":["Circulation: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCHEARTFAILURE.121.008777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:31:09Z","timestamp":1715563869000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCHEARTFAILURE.121.008777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1161\/CIRCHEARTFAILURE.121.008777"],"URL":"https:\/\/doi.org\/10.1161\/circheartfailure.121.008777","relation":{},"ISSN":["1941-3289","1941-3297"],"issn-type":[{"value":"1941-3289","type":"print"},{"value":"1941-3297","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2021-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e008777"}}