{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:31:08Z","timestamp":1793809868143,"version":"4.6.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Global indices of right ventricle (RV) function provide limited insights into mechanisms underlying RV remodeling in pulmonary hypertension (PH). While RV myocardial architectural remodeling has been observed in PH, its effect on RV adaptation is poorly understood.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Hemodynamic assessments were performed in 2 rodent models of PH. RV free wall myoarchitecture was quantified using generalized Q-space imaging and tractography analyses. Computational models were developed to predict RV wall strains. Data from animal studies were analyzed to determine the correlations between hemodynamic measurements, RV strains, and structural measures.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              In contrast to the PH rats with severe RV maladaptation, PH rats with mild RV maladaptation showed a decrease in helical range of fiber orientation in the RV free wall (139\u00ba versus 97\u00ba;\n              <jats:italic>P<\/jats:italic>\n              =0.029), preserved global circumferential strain, and exhibited less reduction in right ventricular-pulmonary arterial coupling (0.029 versus 0.017 mm\/mm\u2009Hg;\n              <jats:italic>P<\/jats:italic>\n              =0.037). Helical range correlated positively with coupling (\n              <jats:italic>P<\/jats:italic>\n              =0.036) and stroke volume index (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). Coupling correlated with global circumferential strain (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) and global radial strain (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) but not global longitudinal strain.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Data analysis suggests that adaptive RV architectural remodeling could improve RV function in PH. Our findings suggest the need to assess RV architecture within routine screenings of PH patients to improve our understanding of its prognostic and therapeutic significance in PH.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.122.009768","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T10:01:05Z","timestamp":1675764065000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":50,"title":["Right Ventricular Architectural Remodeling and Functional Adaptation in Pulmonary Hypertension"],"prefix":"10.1161","volume":"16","author":[{"given":"Emilio A.","family":"Mendiola","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Texas A&amp;M University, College Station (E.A.M., R.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9213-5276","authenticated-orcid":true,"given":"Denielli","family":"da Silva Gon\u00e7alves Bos","sequence":"additional","affiliation":[{"name":"Pulmonary Division\u2013Heart Institute, University of S\u00e3o Paulo Medical School, Brazil (D.d.S.G.B.)."},{"name":"Vascular Research Laboratory, Providence VA Medical Center, RI (D.d.S.G.B., A.V., P.Z., G.C.)."},{"name":"Department of Medicine, Alpert Medical School of Brown University, Providence, RI (D.d.S.G.B., P.Z., G.C.)."},{"name":"Ocean State Research Institute, Providence, RI (D.M.L., A.V., P.Z., O.P.L., R.J.G., G.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6808-1172","authenticated-orcid":true,"given":"Dana M.","family":"Leichter","sequence":"additional","affiliation":[{"name":"Ocean State Research Institute, Providence, RI (D.M.L., A.V., P.Z., O.P.L., R.J.G., G.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5691-781X","authenticated-orcid":true,"given":"Alexander","family":"Vang","sequence":"additional","affiliation":[{"name":"Vascular Research Laboratory, Providence VA Medical Center, RI (D.d.S.G.B., A.V., P.Z., G.C.)."},{"name":"Ocean State Research Institute, Providence, RI (D.M.L., A.V., P.Z., O.P.L., R.J.G., G.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0190-5384","authenticated-orcid":true,"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Vascular Research Laboratory, Providence VA Medical Center, RI (D.d.S.G.B., A.V., P.Z., G.C.)."},{"name":"Department of Medicine, Alpert Medical School of Brown University, Providence, RI (D.d.S.G.B., P.Z., G.C.)."},{"name":"Ocean State Research Institute, Providence, RI (D.M.L., A.V., P.Z., O.P.L., R.J.G., G.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6282-828X","authenticated-orcid":true,"given":"Owen P.","family":"Leary","sequence":"additional","affiliation":[{"name":"Ocean State Research Institute, Providence, RI (D.M.L., A.V., P.Z., O.P.L., R.J.G., G.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Ocean State Research Institute, Providence, RI (D.M.L., A.V., P.Z., O.P.L., R.J.G., G.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9787-1117","authenticated-orcid":true,"given":"Reza","family":"Avazmohammadi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Texas A&amp;M University, College Station (E.A.M., R.A.)."},{"name":"Department of Cardiovascular Sciences, Houston Methodist Academic Institute, TX (R.A.)."},{"name":"J. 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