{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:03:40Z","timestamp":1790262220560,"version":"4.1.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Sacubitril\/valsartan was demonstrated to reduce hospitalization rate and mortality in patients with heart failure with reduced ejection fraction. Data on the effects of sacubitril\/valsartan in patients with a systemic right ventricle are still lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients with transposition of the great arteries following Senning\/Mustard procedure or congenitally corrected transposition of the great arteries with impaired systemic right ventricle systolic function were prospectively included. Primary end points included sacubitril\/valsartan safety and efficacy. Primary efficacy end points were NT-proBNP (N-terminal pro-B-type natriuretic peptide) and systolic function improvement. Secondary end points included New York Heart Association class, 6-minute walking distance, and quality of life change.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fifty patients (38\u00b112 years, 60% male, 35% congenitally corrected transposition of the great arteries) were included and followed for 1 year. No major adverse events occurred. Two (4%) patients ceased treatment due to hypotension and 1 (2%) developed a nephrotic syndrome. The target dose was reached in 20 (42%) patients. NT-proBNP values decreased significantly immediately after treatment initiation, while returned to baseline at 1 year. Echocardiography showed progressive fractional area change increase (29.2\u00b15.8 versus 34.9\u00b15.1%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), and right ventricle global longitudinal strain (\u221213.9 [\u221215.1, \u221211.8] versus \u221215.3 [\u221217.2, \u221213.4]%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001) and free-wall global longitudinal strain (\u221214.3 [\u221217.3, \u221212.3] versus \u221217.2 [\u221219.3, \u221215.8]%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001) raise, whereas tricuspid regurgitation severity improved only in transposition of the great arteries patients (\n                      <jats:italic>P<\/jats:italic>\n                      =0.006). Moreover, 3-dimensional echocardiography demonstrated right ventricle volumes reduction (end-diastolic volume: 181\u00b163 versus 156\u00b150 mL;\n                      <jats:italic>P<\/jats:italic>\n                      =0.002; end-systolic volume: 117\u00b148 versus 89\u00b133 mL;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), and significantly increased systemic right ventricle ejection fraction (35.6\u00b18.1 versus 41.5\u00b17.5%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Clinical improvement was suggested by New York Heart Association class change (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), increased 6-minute walking distance (425 [333, 480] versus 500 [443, 560] m;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001) as well as improved quality of life at 1-year follow-up. Beneficial effects were observed irrespective of the underlying anatomy and were more pronounced in those on target dose.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our data showed that sacubitril\/valsartan is well tolerated and is associated with systemic right ventricle remodeling and improved systolic function as well as improved clinical status, supporting its use in this complex population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circheartfailure.122.009848","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T05:01:36Z","timestamp":1669957296000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":74,"title":["Safety and Efficacy of Sacubitril\/Valsartan in Patients With a Failing Systemic Right Ventricle: A Prospective Single-Center Study"],"prefix":"10.1161","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9061-7834","authenticated-orcid":true,"given":"Flavia","family":"Fusco","sequence":"first","affiliation":[{"name":"Adult Congenital Heart Disease Unit, Monaldi Hospital, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2279-4265","authenticated-orcid":true,"given":"Giancarlo","family":"Scognamiglio","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Disease Unit, Monaldi Hospital, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assunta","family":"Merola","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Disease Unit, Monaldi Hospital, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Iannuzzi","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Disease Unit, Monaldi Hospital, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Palma","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Disease Unit, Monaldi Hospital, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5908-178X","authenticated-orcid":true,"given":"Nicola","family":"Grimaldi","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Disease Unit, Monaldi Hospital, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9941-8500","authenticated-orcid":true,"given":"Berardo","family":"Sarubbi","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Disease Unit, Monaldi Hospital, Naples, 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