{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:14:13Z","timestamp":1790813653757,"version":"4.1.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Exposure to hyperoxia, a high arterial partial pressure of oxygen (PaO2), may be associated with worse outcomes in patients receiving extracorporeal membrane oxygenator (ECMO) support. We examined hyperoxia in the Extracorporeal Life Support Organization Registry among patients receiving venoarterial ECMO for cardiogenic shock.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We included Extracorporeal Life Support Organization Registry patients from 2010 to 2020 who received venoarterial ECMO for cardiogenic shock, excluding extracorporeal CPR. Patients were grouped based on PaO2 after 24 hours of ECMO: normoxia (PaO2 60\u2013150 mmHg), mild hyperoxia (PaO2 151\u2013300 mmHg), and severe hyperoxia (PaO2 &gt;300 mmHg). In-hospital mortality was evaluated using multivariable logistic regression.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Among 9959 patients, 3005 (30.2%) patients had mild hyperoxia and 1972 (19.8%) had severe hyperoxia. In-hospital mortality increased across groups: normoxia, 47.8%; mild hyperoxia, 55.6% (adjusted odds ratio, 1.37 [95% CI, 1.23\u20131.53];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001); severe hyperoxia, 65.4% (adjusted odds ratio, 2.20 [95% CI, 1.92\u20132.52];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). A higher PaO2 was incrementally associated with increased in-hospital mortality (adjusted odds ratio, 1.14 per 50 mmHg higher [95% CI, 1.12\u20131.16];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Patients with a higher PaO2 had increased in-hospital mortality in each subgroup and when stratified by ventilator settings, airway pressures, acid-base status, and other clinical variables. In the random forest model, PaO2 was the second strongest predictor of in-hospital mortality, after older age.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Exposure to hyperoxia during venoarterial ECMO support for cardiogenic shock is strongly associated with increased in-hospital mortality, independent from hemodynamic and ventilatory status. Until clinical trial data are available, we suggest targeting a normal PaO2 and avoiding hyperoxia in CS patients receiving venoarterial ECMO.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.122.010328","type":"journal-article","created":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T16:21:06Z","timestamp":1678033266000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Exposure to Arterial Hyperoxia During Extracorporeal Membrane Oxygenator Support and Mortality in Patients With Cardiogenic Shock"],"prefix":"10.1161","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6366-2859","authenticated-orcid":true,"given":"Jacob C.","family":"Jentzer","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (J.C.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0595-1492","authenticated-orcid":true,"given":"P. Elliott","family":"Miller","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT (P.E.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Alviar","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, New York University School of Medicine, New York (C.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraj","family":"Yalamuri","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN (S.Y., J.K.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9699-0325","authenticated-orcid":true,"given":"J. Kyle","family":"Bohman","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN (S.Y., J.K.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8879-2628","authenticated-orcid":true,"given":"Joseph E.","family":"Tonna","sequence":"additional","affiliation":[{"name":"Divisions of Cardiothoracic Surgery and Emergency Medicine, University of Utah Health and School of Medicine, Salt Lake City (J.E.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.11.038"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000959"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjacc\/zuac119"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000998"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-019-0810-1"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacadv.2022.100065"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-1968-2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0996-4"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002643"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2022.03.016"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005069"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aucc.2020.04.154"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000655"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001439"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003938"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-022-02598-6"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.867602"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-021-02361-3"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2018.04.008"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2020.09.036"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003993"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc12554"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01963"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.07.015"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30479-3"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-021-01634-4"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/0267659119830513"}],"container-title":["Circulation: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCHEARTFAILURE.122.010328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:19:24Z","timestamp":1715563164000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCHEARTFAILURE.122.010328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1161\/CIRCHEARTFAILURE.122.010328"],"URL":"https:\/\/doi.org\/10.1161\/circheartfailure.122.010328","relation":{},"ISSN":["1941-3289","1941-3297"],"issn-type":[{"value":"1941-3289","type":"print"},{"value":"1941-3297","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"2022-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}