{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:09:07Z","timestamp":1790845747611,"version":"4.1.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>In 2018, an algorithm-based allocation system for heart transplantation (HT) was implemented in France. Its effect on access to HT of patients with rare causes of heart failure (HF) has not been assessed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>In this national study, including adults listed for HT between 2018 and 2020, we analyzed waitlist and posttransplant outcomes of candidates with rare causes of HF (restrictive cardiomyopathy [RCM], hypertrophic cardiomyopathy, and congenital heart disease). The primary end point was death on the waitlist or delisting for clinical deterioration. Secondary end points included access to HT and posttransplant mortality. The cumulative incidence of waitlist mortality estimated with competing risk analysis and incidence of transplantation were compared between diagnosis groups. The association of HF cause with outcomes was determined by Fine-Gray or Cox models.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Overall, 1604 candidates were listed for HT. At 1 year postlisting, 175 patients met the primary end point and 1040 underwent HT. Candidates listed for rare causes of HF significantly differed in baseline characteristics and had more frequent score exceptions compared with other cardiomyopathies (31.3%, 32.0%, 36.4%, and 16.7% for patients with hypertrophic cardiomyopathy, RCM, congenital heart disease, and other cardiomyopathies). The cumulative incidence of death on the waitlist and probability of HT were similar between diagnosis groups (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.17 and 0.40, respectively). The adjusted risk of death or delisting for clinical deterioration did not significantly differ between candidates with rare and common causes of HF (subdistribution hazard ratio (HR): hypertrophic cardiomyopathy, 0.51 [95% CI, 0.19\u20131.38];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.18; RCM, 1.04 [95% CI, 0.42\u20132.58];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.94; congenital heart disease, 1.82 [95% CI, 0.78\u20134.26];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.17). Similarly, the access to HT did not significantly differ between causes of HF (hypertrophic cardiomyopathy: HR, 1.18 [95% CI, 0.92\u20131.51];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.19; RCM: HR, 1.19 [95% CI, 0.90\u20131.58];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.23; congenital heart disease: HR, 0.76 [95% CI, 0.53\u20131.09];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.14). RCM was an independent risk factor for 1-year posttransplant mortality (HR, 2.12 [95% CI, 1.06\u20134.24];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.03).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Our study shows equitable waitlist outcomes among HT candidates whatever the indication for transplantation with the new French allocation scheme.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.123.010837","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T10:02:43Z","timestamp":1706781763000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Waitlist Outcomes in Candidates With Rare Causes of Heart Failure After Implementation of the 2018 French Heart Allocation Scheme"],"prefix":"10.1161","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7752-1144","authenticated-orcid":true,"given":"Camille","family":"Legeai","sequence":"first","affiliation":[{"name":"Agence de la Biom\u00e9decine, Saint Denis La Plaine Cedex, France (C.L., C.C., C.J., F.K., R.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4939-2175","authenticated-orcid":true,"given":"Guillaume","family":"Coutance","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Surgery, Cardiology Institute, Pitie\u0301 Salpe\u0302trie\u0300re Hospital (G.C.), Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Sorbonne University Medical School, France."},{"name":"University of Paris, INSERM UMR 970, Paris Translational Research Centre for Organ Transplantation, France (G.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3737-1126","authenticated-orcid":true,"given":"Christelle","family":"Cantrelle","sequence":"additional","affiliation":[{"name":"Agence de la Biom\u00e9decine, Saint Denis La Plaine Cedex, France (C.L., C.C., C.J., F.K., R.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9815-0271","authenticated-orcid":true,"given":"Carine","family":"Jasseron","sequence":"additional","affiliation":[{"name":"Agence de la Biom\u00e9decine, Saint Denis La Plaine Cedex, France (C.L., C.C., C.J., F.K., R.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4857-5474","authenticated-orcid":true,"given":"Marylou","family":"Para","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Bichat Hospital (M.P.), Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Sorbonne University Medical School, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Sebbag","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Louis Pradel Hospital, Hospices Civils de Lyon, Bron, France (L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Battistella","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Arnaud de Villeneuve Hospital, Montpellier, France (P.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Kerbaul","sequence":"additional","affiliation":[{"name":"Agence de la Biom\u00e9decine, Saint Denis La Plaine Cedex, France (C.L., C.C., C.J., F.K., R.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6159-1372","authenticated-orcid":true,"given":"Richard","family":"Dorent","sequence":"additional","affiliation":[{"name":"Agence de la Biom\u00e9decine, Saint Denis La Plaine Cedex, France (C.L., C.C., C.J., F.K., R.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.07.010"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.10.023"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14354"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15816"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.06.013"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.119.005795"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.120.007000"},{"key":"e_1_3_3_10_2","unstructured":"UNOS. 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