{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:53:38Z","timestamp":1788893618135,"version":"build-2803163510"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Heart transplant (HT) in recipients with left ventricular assist devices (LVADs) is associated with poor early post-HT outcomes, including primary graft dysfunction (PGD). As complicated heart explants in recipients with LVADs may produce longer ischemic times, innovations in donor heart preservation may yield improved post-HT outcomes. The SherpaPak Cardiac Transport System is an organ preservation technology that maintains donor heart temperatures between 4\u2005\u00b0C and 8\u2005\u00b0C, which may minimize ischemic and cold-induced graft injuries. This analysis sought to identify whether the use of SherpaPak versus traditional cold storage was associated with differential outcomes among patients with durable LVAD undergoing HT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Global Utilization and Registry Database for Improved Heart Preservation-Heart (NCT04141605) is a multicenter registry assessing post-HT outcomes comparing 2 methods of donor heart preservation: SherpaPak versus traditional cold storage. A retrospective review of all patients with durable LVAD who underwent HT was performed. Outcomes assessed included rates of PGD, post-HT mechanical circulatory support use, and 30-day and 1-year survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      SherpaPak (n=149) and traditional cold storage (n=178) patients had similar baseline characteristics. SherpaPak use was associated with reduced PGD (adjusted odds ratio, 0.56 [95% CI, 0.32\u20130.99];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.045) and severe PGD (adjusted odds ratio, 0.31 [95% CI, 0.13\u20130.75];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.009), despite an increased total ischemic time in the SherpaPak group. Propensity matched analysis also noted a trend toward reduced intensive care unit (SherpaPak 7.5\u00b16.4 days versus traditional cold storage 11.3\u00b118.8 days;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.09) and hospital (SherpaPak 20.5\u00b111.9 days versus traditional cold storage 28.7\u00b137.0 days;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.06) lengths of stay. The 30-day and 1-year survival was similar between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>SherpaPak use was associated with improved early post-HT outcomes among patients with LVAD undergoing HT. This innovation in preservation technology may be an option for HT candidates at increased risk for PGD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT04141605.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circheartfailure.123.010904","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T05:00:38Z","timestamp":1712811638000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Early Outcomes in Patients With LVAD Undergoing Heart Transplant via Use of the SherpaPak Cardiac Transport System"],"prefix":"10.1161","volume":"17","clinical-trial-number":[{"clinical-trial-number":"nct04141605","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1522-0308","authenticated-orcid":true,"given":"Joseph B.","family":"Lerman","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology (J.B.L., C.B.P., S.C., C.L.H., A.D.D.), Duke University Hospital, Durham, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan B.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology (J.B.L., C.B.P., S.C., C.L.H., A.D.D.), Duke University Hospital, Durham, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2157-0251","authenticated-orcid":true,"given":"Sarah","family":"Casalinova","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology (J.B.L., C.B.P., S.C., C.L.H., A.D.D.), Duke University Hospital, Durham, NC."},{"name":"Department of Surgery, Division of Cardiovascular and Thoracic Surgery, (S.C., A.N., C.A.M., J.N.S.), Duke University Hospital, Durham, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3814-6182","authenticated-orcid":true,"given":"Alina","family":"Nicoara","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Cardiovascular and Thoracic Surgery, (S.C., A.N., C.A.M., J.N.S.), Duke University Hospital, Durham, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2870-3352","authenticated-orcid":true,"given":"Christopher L.","family":"Holley","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology (J.B.L., C.B.P., S.C., C.L.H., A.D.D.), Duke University Hospital, Durham, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Leacche","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Corewell Health, Grand Rapids, MI (M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1847-5218","authenticated-orcid":true,"given":"Scott","family":"Silvestry","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, AdventHealth Transplant Institute, Orlando, FL (S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8054-8150","authenticated-orcid":true,"given":"Andreas","family":"Zuckermann","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Vienna, Austria (A.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9693-7313","authenticated-orcid":true,"given":"David A.","family":"D\u2019Alessandro","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston (D.A.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8678-3226","authenticated-orcid":true,"given":"Carmelo A.","family":"Milano","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Cardiovascular and Thoracic Surgery, (S.C., A.N., C.A.M., J.N.S.), Duke University Hospital, Durham, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5836-7284","authenticated-orcid":true,"given":"Jacob N.","family":"Schroder","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Cardiovascular and Thoracic Surgery, (S.C., A.N., C.A.M., J.N.S.), Duke University Hospital, Durham, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam 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