{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:29:41Z","timestamp":1792794581281,"version":"4.5.0"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Systemic hemodynamics and specific ventilator settings have been shown to predict survival during venoarterial extracorporeal membrane oxygenation (ECMO). How the right heart (the right ventricle and pulmonary artery) affect survival during venoarterial ECMO is unknown. We aimed to identify the relationship between right heart function with mortality and the duration of ECMO support.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>Cardiac ECMO runs in adults from the Extracorporeal Life Support Organization Registry between 2010 and 2022 were queried. Right heart function was quantified via pulmonary artery pulse pressure (PAPP) for pre-ECMO and on-ECMO periods. A multivariable model was adjusted for modified Society for Cardiovascular Angiography and Interventions stage, age, sex, and concurrent clinical data (ie, pulmonary vasodilators and systemic pulse pressure). The primary outcome was in-hospital mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              A total of 4442 ECMO runs met inclusion criteria and had documentation of hemodynamic and illness severity variables. The mortality rate was 55%; nonsurvivors were more likely to be older, have a worse Society for Cardiovascular Angiography and Interventions stage, and have longer pre-ECMO endotracheal intubation times (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.05 for all) than survivors. Increasing PAPP from pre-ECMO to on-ECMO time (\u0394PAPP) was associated with reduced mortality per 2 mm\u2005Hg increase (odds ratio, 0.98 [95% CI, 0.97\u20130.99];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.002). Higher on-ECMO PAPP was associated with mortality reduction across quartiles with the greatest reduction in the third PAPP quartile (odds ratio, 0.75 [95% CI, 0.63\u20130.90];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.002) and longer time on ECMO per 10 mm\u2005Hg (beta, 15 [95% CI, 7.7\u201321];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Early on-ECMO right heart function and interval improvement from pre-ECMO values were associated with mortality reduction during cardiac ECMO. Incorporation of right heart metrics into risk prediction models should be considered.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.123.011123","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T09:00:32Z","timestamp":1720515632000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Pulmonary Artery Pressures and Mortality During Venoarterial ECMO: An ELSO Registry Analysis"],"prefix":"10.1161","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9435-2944","authenticated-orcid":true,"given":"Clark G.","family":"Owyang","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine (C.G.O.), New York-Presbyterian Hospital\/Weill Cornell Medical College, New York."},{"name":"Department of Emergency Medicine (C.G.O., F.T.), New York-Presbyterian Hospital\/Weill Cornell Medical College, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brady","family":"Rippon","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, Weill Cornell Medical College, New York, NY (B.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1137-0800","authenticated-orcid":true,"given":"Felipe","family":"Teran","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine (C.G.O., F.T.), New York-Presbyterian Hospital\/Weill Cornell Medical College, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0813-3145","authenticated-orcid":true,"given":"Daniel","family":"Brodie","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD (D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-9769","authenticated-orcid":true,"given":"Joaquin","family":"Araos","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY (J.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3995-2466","authenticated-orcid":true,"given":"Daniel","family":"Burkhoff","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation, New York, NY (D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8420-8604","authenticated-orcid":true,"given":"Jiwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine (J.K.), New York-Presbyterian Hospital\/Weill Cornell Medical College, New 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