{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:07:19Z","timestamp":1792512439361,"version":"4.5.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>In October 2018, the US heart transplant (HT) allocation system was revised giving patients with left ventricular assist device (LVAD) intermediate priority status. Few studies have examined the impact of this policy change on outcomes among patients with LVAD. We sought to determine how the allocation change impacted waitlist and posttransplant mortality in patients with LVAD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>We retrospectively assessed the United Network for Organ Sharing registry for patients with LVAD who were listed for or underwent HT between October 2016 and October 2021. We evaluated waitlist mortality using competing risks analysis and a multivariable Fine-Gray model, and posttransplant mortality using Kaplan-Meier survival analysis and a multivariate proportional hazards model.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              We analyzed data from 3835 patients with LVAD listed for HT and 3486 patients with LVAD who underwent HT during the study period. Listing for HT preallocation change was significantly associated with an increased risk of waitlist mortality (Gray\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.0058) compared with postallocation change. After adjustment for covariates, mortality differences by listing era were attenuated, but LVAD brand was significantly associated with waitlist mortality (HM3 versus HMII; hazard ratio, 0.38 [95% CI, 0.21\u20130.69];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.002; HVAD versus HMII; hazard ratio, 0.79 [95% CI, 0.48\u20131.30];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.36; overall\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.004).\n            <\/jats:p>\n            <jats:p>\n              In contrast, HT postallocation change was associated with increased posttransplant mortality (log-rank\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.0172) compared with preallocation change. In a multivariable analysis, the association with posttransplant mortality between transplant eras was attenuated, but ischemic time (hazard ratio, 1.16 [95% CI, 1.07\u20131.26];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001) and status at time of HT (Status 1\u20133 versus 4; hazard ratio, 1.29 [95% CI, 1.04\u20131.61];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.02) were significantly associated with posttransplant mortality.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Among patients with LVAD, lower waitlist mortality postallocation change was likely driven by improved LVAD technology. Higher posttransplant mortality following the allocation change was largely attributable to longer ischemic times and patient acuity.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.124.011621","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T09:00:45Z","timestamp":1729155645000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of Heart Transplant Allocation Change on Waitlist Mortality and Posttransplant Mortality in Patients With Left Ventricular Assist Devices"],"prefix":"10.1161","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3376-7748","authenticated-orcid":true,"given":"Anjan","family":"Tibrewala","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine (A.T., S.C., J.E.W.), Northwestern University, Chicago, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5348-2742","authenticated-orcid":true,"given":"Sarah","family":"Chuzi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine (A.T., S.C., J.E.W.), Northwestern University, Chicago, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2816-6590","authenticated-orcid":true,"given":"Tingqing","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery (T.W., A.S.B., R.H., B.B., D.T.P.), Northwestern University, Chicago, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1573-0554","authenticated-orcid":true,"given":"Abigail S.","family":"Baldridge","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery (T.W., A.S.B., R.H., B.B., D.T.P.), Northwestern University, Chicago, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Harap","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery (T.W., A.S.B., R.H., B.B., D.T.P.), Northwestern University, Chicago, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Bryner","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery (T.W., A.S.B., R.H., B.B., D.T.P.), Northwestern University, Chicago, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4443-601X","authenticated-orcid":true,"given":"Duc Thinh","family":"Pham","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery (T.W., A.S.B., R.H., B.B., D.T.P.), Northwestern University, Chicago, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E.","family":"Wilcox","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine (A.T., S.C., J.E.W.), Northwestern University, Chicago, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001123"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.10.020"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1236"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.12.012"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.10.023"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909938"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012175"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004586"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800866"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2022.11.023"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.16197"},{"key":"e_1_3_3_13_2","unstructured":"Organ Procurement and Transplantation Network. 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