{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T18:51:25Z","timestamp":1777315885777,"version":"3.51.4"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>\n              The long-term impact of bariatric surgery on cardiac mechanics and energetics has been scarcely documented. We aimed to assess prospectively the 5-year trajectories of left heart geometry, mechanics, and myocardial oxygen (O\n              <jats:sub>2<\/jats:sub>\n              ) demand after bariatric surgery.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>\n              In the Bariatric Surgery on the West Coast of Norway study, left ventricular (LV) and atrial remodeling was evaluated preoperatively, 6 months, and 1 and 5 years after Roux-en-Y gastric bypass in 102 patients. LV geometry was assessed by the LV mass\/height\n              <jats:sup>2.7<\/jats:sup>\n              and the relative wall thickness, and mechanics by the global longitudinal strain and the midwall shortening. LV myocardial O\n              <jats:sub>2<\/jats:sub>\n              demand was estimated from the product LV mass\u00d7wall stress\u00d7heart rate. The left atrial reservoir function was measured by the emptying fraction.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              After 63 (interquartile range, 62\u201366) months, LV mass index, global longitudinal strain, myocardial oxygen demand, and left atrial emptying fraction were improved (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001) while midwall shortening did not change significantly. Prevalence of normal LV geometry increased from 61% to 82%. In linear mixed-effects models with adjustment for clinical characteristics, improving global longitudinal strain and myocardial O\n              <jats:sub>2<\/jats:sub>\n              demand over time were associated with female sex and lower body mass index (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.05). In logistic regression analysis, 5-year presence of abnormal LV geometry, low LV global longitudinal strain, or high myocardial O\n              <jats:sub>2<\/jats:sub>\n              demand was related to preoperative diabetes, hypertension, and higher body mass index, as well as higher 5-year systolic blood pressure (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.05; Nagelkerke R\n              <jats:sup>2<\/jats:sup>\n              =0.40).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>\n              Bariatric surgery results in favorable 5-year trajectories of LV geometry, myocardial O\n              <jats:sub>2<\/jats:sub>\n              demand, and left heart longitudinal mechanics. However, suboptimal postoperative body mass index and blood pressure control promote long-term LV structural disease.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT01533142.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.124.012367","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T09:00:22Z","timestamp":1744016422000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Long-Term Trajectories of Left Heart Geometry, Mechanics, and Oxygen Demand After Bariatric Surgery"],"prefix":"10.1161","volume":"18","clinical-trial-number":[{"clinical-trial-number":"nct01533142","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9310-6394","authenticated-orcid":true,"given":"Lisa M.D.","family":"Grymyr","sequence":"first","affiliation":[{"name":"Department of Heart Disease, Haukeland University Hospital, Bergen, Norway (L.M.D.G., D.C.)."},{"name":"Department of Clinical Science (L.M.D.G., K.M., D.C.), University of Bergen, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saied","family":"Nadirpour","sequence":"additional","affiliation":[{"name":"Department of Medicine, Haugesund Hospital, Norway (S.N., B.G.N.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4109-2311","authenticated-orcid":true,"given":"Eva","family":"Gerdts","sequence":"additional","affiliation":[{"name":"Center for Research on Cardiac Disease in Women, Department of Clinical Science (E.G.), University of Bergen, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f8rn G.","family":"Nedreb\u00f8","sequence":"additional","affiliation":[{"name":"Department of Medicine, Haugesund Hospital, Norway (S.N., B.G.N.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2902-3404","authenticated-orcid":true,"given":"Knut","family":"Matre","sequence":"additional","affiliation":[{"name":"Department of Clinical Science (L.M.D.G., K.M., D.C.), University of Bergen, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1593-2017","authenticated-orcid":true,"given":"Dana","family":"Cramariuc","sequence":"additional","affiliation":[{"name":"Department of Heart Disease, Haukeland University Hospital, Bergen, Norway (L.M.D.G., D.C.)."},{"name":"Department of Clinical Science (L.M.D.G., K.M., D.C.), University of Bergen, 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