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This review integrates the existing evidence on the utility and safety of various induction regimens and highlights the gaps of knowledge in the field. In addition, we frame the discussion in view of the changing landscape of heart transplantation where many unknowns remain, such as the impact of induction immunosuppression on patients bridged with mechanical circulatory devices or receiving organs from hepatitis C\u2013positive or donation after circulatory death donors, among others.<\/jats:p>","DOI":"10.1161\/circheartfailure.124.012382","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T05:00:44Z","timestamp":1747285244000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Practical Guide on the Use of Induction Immunosuppression in Heart Transplantation"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2274-5869","authenticated-orcid":true,"given":"Andriana P.","family":"Nikolova","sequence":"first","affiliation":[{"name":"Smidt Heart Institute, Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA (A.P.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9317-9067","authenticated-orcid":true,"given":"Lavanya","family":"Bellumkonda","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Yale University (L.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2322-2442","authenticated-orcid":true,"given":"Anju","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Advanced Cardiopulmonary Therapies and Transplantation, Department of Cardiology, University of Texas, Texas Medical Center at Houston (A.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4044-5007","authenticated-orcid":true,"given":"Nadia","family":"Fida","sequence":"additional","affiliation":[{"name":"Division of Advanced Heart Failure and Transplant, Department of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital, TX (N.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7908-4611","authenticated-orcid":true,"given":"Luise","family":"Holzhauser","sequence":"additional","affiliation":[{"name":"Advanced Heart Failure, Transplantation and Mechanical Circulatory Support, Department of Cardiology, University of Pennsylvania, Philadelphia (L.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1872-6753","authenticated-orcid":true,"given":"Priya","family":"Umapathi","sequence":"additional","affiliation":[{"name":"Advanced Heart Failure, Transplant and MCS Section, Division of Cardiology, Johns Hopkins, Baltimore, MD (P.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0183-4704","authenticated-orcid":true,"given":"Teresa","family":"De Marco","sequence":"additional","affiliation":[{"name":"Advanced Heart Failure and Transplant Cardiology, Department of Medicine, Division of Cardiology, University of California San Francisco (T.D.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8311-6628","authenticated-orcid":true,"given":"Johanna","family":"Contreras","sequence":"additional","affiliation":[{"name":"Advanced Heart Failure and Transplant Cardiology, Department of Medicine, Division of Cardiology, Mount Sinai School of Medicine, Mount Sinai Fuster Heart Hospital, New York (J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2023.02.008"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.056"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16420"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2023.05.005"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.17060"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.10.015"},{"key":"e_1_3_3_8_2","first-page":"373","article-title":"Basiliximab, mechanism of action and pharmacological properties.","volume":"58","author":"Kapic E","year":"2004","unstructured":"Kapic E, Becic F, Kusturica J. 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