{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:12:34Z","timestamp":1787501554511,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Blood transfusion may precipitate adverse outcomes, including heart failure (HF), among patients with acute myocardial infarction (MI). This study characterizes the effects of a restrictive or liberal transfusion strategy on outcomes in patients with MI and anemia with and without baseline HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>In the MINT trial (Myocardial Ischemia and Transfusion), 3504 patients with MI and anemia (hemoglobin &lt;10 g\/dL) were randomized to a restrictive (hemoglobin &lt;8 g\/dL) or liberal (hemoglobin &lt;10 g\/dL) transfusion strategy. We compared the effects of transfusion strategy on outcomes among patients with and without baseline HF. The primary outcome was death or HF at 30 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Compared with patients without baseline HF (n=1633), those with baseline HF (n=1871) had higher rates of death or HF (18.0% versus 10.0%) at 30 days. Restrictive transfusion resulted in numerically higher rates of death or HF (rate ratio, 1.20 [95% CI, 0.99\u20131.45] versus 0.94 [95% CI, 0.70\u20131.26];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      <jats:sub>interaction<\/jats:sub>\n                      =0.18) in patients with than in those without baseline HF. Among secondary outcomes, death or recurrent MI and death were more frequent among those with baseline HF. Restrictive transfusion resulted in numerically higher rates of death or MI and death in patients with than in those without baseline HF. Rates of HF were similar between restrictive and liberal transfusion in patients with baseline HF but lower with restrictive transfusion (rate ratio, 0.51 [95% CI, 0.29\u20130.92];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      <jats:sub>interaction<\/jats:sub>\n                      =0.02) in patients without baseline HF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>A liberal transfusion strategy is safe for patients with MI and anemia, including those with baseline HF. Restrictive transfusion tended to result in worse outcomes, particularly in patients with baseline HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT02981407.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circheartfailure.124.012495","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T05:09:43Z","timestamp":1742965783000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Blood Transfusion in Patients With Acute Myocardial Infarction, Anemia, and Heart Failure: Lessons From MINT"],"prefix":"10.1161","volume":"18","clinical-trial-number":[{"clinical-trial-number":"nct02981407","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2952-7837","authenticated-orcid":true,"given":"Andrew M.","family":"Goldsweig","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Baystate Medical Center (A.M.G.)"},{"name":"Division of Cardiovascular Medicine (A.M.G.), University of Massachusetts-Baystate, Springfield, MA."},{"name":"Division of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, NE (A.M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0543-9798","authenticated-orcid":true,"given":"William J.","family":"Kostis","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease and Hypertension, Robert Wood Johnson Medical School, New Brunswick, NJ (W.J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3857-7422","authenticated-orcid":true,"given":"Brandon M.","family":"Herbert","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh School of Public Health, PA (B.M.H., M.M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6922-0093","authenticated-orcid":true,"given":"Claire","family":"Bouleti","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Poitiers, France (C.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0316-9026","authenticated-orcid":true,"given":"Brian J.","family":"Potter","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Centre Hospitalier de L\u2019Universite de Montreal, QC, Canada (B.J.P., P.C.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6592-6141","authenticated-orcid":true,"given":"Jordan B.","family":"Strom","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (J.B.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6724-8997","authenticated-orcid":true,"given":"Jocelyne","family":"Benatar","sequence":"additional","affiliation":[{"name":"Cardiovascular Directorate, Te Toka Tumai, Auckland, New Zealand (J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5082-1363","authenticated-orcid":true,"given":"Thao","family":"Huynh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, McGill University, Montreal, QC, Canada (T.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikanth","family":"Vallurupalli","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Arkansas for Medical Sciences, Little Rock (S.R.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5420-2482","authenticated-orcid":true,"given":"Est\u00eav\u00e3o Lanna","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Instituto Orizonti, Belo Horizonte, Brazil (E.L.F.)."},{"name":"NUPEC, Belo Horizonte, Brazil (E.L.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2560-0155","authenticated-orcid":true,"given":"J. Dawn","family":"Abbott","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Brown University and Lifespan Cardiovascular Institute, Providence, RI (J.D.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard A.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Westchester Medical Center, Valhalla, NY (H.A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5135-9748","authenticated-orcid":true,"given":"Andrew P.","family":"DeFilippis","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN (A.P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean A.","family":"Fergusson","sequence":"additional","affiliation":[{"name":"Department of Medicine (D.A.F.), University of Ottawa, ON, Canada."},{"name":"Department of Surgery (D.A.F.), University of Ottawa, ON, Canada."},{"name":"School of Epidemiology and Public Health (D.A.F.), University of Ottawa, ON, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8068-2440","authenticated-orcid":true,"given":"Shaun G.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Peter Munk Cardiac Centre, St. Michael\u2019s Hospital, Toronto, ON, Canada (S.G.G.)."},{"name":"University of Toronto, ON, Canada (S.G.G.)."},{"name":"Canadian VIGOUR Centre, University of Alberta, Edmonton, AB, Canada (S.G.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0440-8586","authenticated-orcid":true,"given":"Paul C.","family":"H\u00e9bert","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Centre Hospitalier de L\u2019Universite de Montreal, QC, Canada (B.J.P., P.C.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-4961","authenticated-orcid":true,"given":"Renato D.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Duke Clinical Research Institute and Duke University, Durham, NC (R.D.L., J.H.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2914-0894","authenticated-orcid":true,"given":"Sunil V.","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Baystate Medical Center (A.M.G.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4550-0450","authenticated-orcid":true,"given":"Tabassome","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Sorbonne University, Paris, France (T.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5466-2833","authenticated-orcid":true,"given":"Jeffrey L.","family":"Carson","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2030-7873","authenticated-orcid":true,"given":"Maria Mori","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh School of Public Health, PA (B.M.H., M.M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1444-2462","authenticated-orcid":true,"given":"John H.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Duke Clinical Research Institute and Duke University, Durham, NC (R.D.L., J.H.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the MINT Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307983"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2024.132111"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2022.11.015"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.001"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.04.061"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.583666"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.12914"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.071208"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2024.02.013"}],"container-title":["Circulation: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCHEARTFAILURE.124.012495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T15:52:35Z","timestamp":1756482755000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCHEARTFAILURE.124.012495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1161\/CIRCHEARTFAILURE.124.012495"],"URL":"https:\/\/doi.org\/10.1161\/circheartfailure.124.012495","relation":{},"ISSN":["1941-3289","1941-3297"],"issn-type":[{"value":"1941-3289","type":"print"},{"value":"1941-3297","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}