{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:18:41Z","timestamp":1774477121572,"version":"3.50.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>The importance of gastrointestinal hormones, including the incretins glucagon-like peptide-1 (GLP-1) and GIP (glucose-dependent insulinotropic polypeptide), in heart failure pathophysiology is debated. The postprandial incretin response and its relation to hemodynamic changes in patients with heart failure, however, remains unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>A pulmonary artery catheter was placed in 14 patients with chronic heart failure and 10 healthy controls, who subsequently consumed a standardized meal (3.2 MJ). Hemodynamic measures and blood samples were collected over 120 minutes. Bowel wall thickness and superior mesenteric artery blood flow were measured by ultrasound. Gastrointestinal symptoms were assessed through questionnaires.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Patients, compared with controls, exhibited an impaired postprandial peak in cardiac index (2.8 versus 4.0 L\/min per m\u00b2,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001) and a blunted cardiac index response in the postprandial period (baseline-substracted area under the curve,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.030). Patients had higher fasting total GLP-1 levels (14.0 versus 7.5 pmol\/L,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.015) and a greater postprandial peak (33.5 versus 21.0 pmol\/L,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.013). Fasting total GLP-1 concentrations correlated with central venous pressure (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.025). There was a trend toward a correlation between area under the curve total GLP-1 and cardiac index (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.054). There was no change in GIP concentrations. Patients had a higher gastrointestinal symptom burden (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.033), and an indigestion score that correlated with peak superior mesenteric artery blood flow (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.017).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Patients with heart failure showed a blunted cardiac index response to meal intake, elevated total GLP-1 levels that were associated with hemodynamic parameters, and increased gastrointestinal symptom burden.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circheartfailure.124.012630","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T09:04:31Z","timestamp":1744016671000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of a Meal on Invasive Hemodynamics and Plasma Incretin Levels in Patients With Heart Failure"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1837-6538","authenticated-orcid":true,"given":"Tania","family":"Deis","sequence":"first","affiliation":[{"name":"Department of Cardiology, Rigshospitalet, Copenhagen, Denmark (T.D., K.R., M.E., W.H.N., F.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5253-1247","authenticated-orcid":true,"given":"Kasper","family":"Rossing","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet, Copenhagen, Denmark (T.D., K.R., M.E., W.H.N., F.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4087-8385","authenticated-orcid":true,"given":"Mads","family":"Ersb\u00f8ll","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet, Copenhagen, Denmark (T.D., K.R., M.E., W.H.N., F.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2783-6409","authenticated-orcid":true,"given":"William Herrik","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet, Copenhagen, Denmark (T.D., K.R., M.E., W.H.N., F.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5386-7340","authenticated-orcid":true,"given":"Birthe","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Rigshospitalet, Copenhagen, Denmark (B. Henriksen)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8509-2036","authenticated-orcid":true,"given":"Bolette","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (B. Hartmann, J.J.H.)."},{"name":"Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark (B. Hartmann, J.J.H., J.P.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-3805","authenticated-orcid":true,"given":"Jens Juul","family":"Holst","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (B. Hartmann, J.J.H.)."},{"name":"Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark (B. Hartmann, J.J.H., J.P.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3019-6775","authenticated-orcid":true,"given":"Caroline","family":"Kistorp","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark (C.K.)."},{"name":"Department of Clinical Medicine, University of Copenhagen, Denmark (F.G., C.K)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8671-7007","authenticated-orcid":true,"given":"Marat","family":"Fudim","sequence":"additional","affiliation":[{"name":"Duke University Medical Center, Durham, NC (M.F.)."},{"name":"Duke Clinical Research Institute, Durham, NC (M.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens Peter","family":"Goetze","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark (B. 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