{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:59:57Z","timestamp":1789984797953,"version":"4.0.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Cardiomyopathy guidelines recommend routine screening of at-risk relatives with dilated cardiomyopathy (DCM). Titin-truncating variants are the most prevalent cause. However, the diagnostic yield of screening is low. Risk-based stratification could optimize screening intervals and resource allocation. This study aims to develop a safe, evidence-based gene-specific longitudinal screening algorithm for DCM development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We included likely pathogenic\/pathogenic titin-truncating variant relatives from 7 centers who underwent cardiac screening. Relatives were stratified based on their baseline clinical phenotype: genotype-positive\/phenotype-negative (no left ventricular dysfunction and dilatation) or partial DCM (ie, fulfilling only 1 criterion). DCM development predictors were identified based on follow-up data. Risk profiles were established and used to develop a multistate model to create a longitudinal screening algorithm to safely and effectively monitor titin-truncating variant relatives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Among 413 relatives, follow-up data were available in 301 relatives (median follow-up 5.7 years), of whom 24.6% developed left ventricular dysfunction or dilatation and 17.3% developed DCM. In total, 16 relatives (5.3%) experienced a major adverse cardiac event after DCM diagnosis. Based on the identified risk factors, age \u226530 years, male sex, and partial DCM, 3 distinct profiles were established: (1) relatives with partial DCM, (2) females \u226530 years and males, and (3) female relatives &lt;30 years. A screening algorithm was developed, recommending intervals of 1, 3, and 5 years, optimizing the balance between safety and effectiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>An evidence-based genotype-specific longitudinal screening algorithm that integrates age, sex, and echocardiographic measurements may improve patient care and improve efficiency of clinical resource allocation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circheartfailure.125.013822","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:00:19Z","timestamp":1789981219000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Optimizing Screening Intervals for At-Risk Relatives of Dilated Cardiomyopathy Carrying a TTNtv"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2674-8709","authenticated-orcid":true,"given":"Steven A.","family":"Muller","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht, the Netherlands (S.A.M., A.S.J.M.T.R.)."},{"name":"Netherlands Heart Institute, Utrecht (S.A.M., A.S.J.M.T.R.)."},{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.A.M., N.J.B., A.P., C.G.-M., D.R.K., M.F.G.H.M.V., E.d.M., F.D., M.D.F., M.M., S.L.V.M.S., G.S., A.S.A., P.G.-P., A.S.J.M.T.R., J.A.J.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0605-4604","authenticated-orcid":true,"given":"Nina J.","family":"Beelen","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.A.M., N.J.B., A.P., C.G.-M., D.R.K., M.F.G.H.M.V., E.d.M., F.D., M.D.F., M.M., S.L.V.M.S., G.S., A.S.A., P.G.-P., A.S.J.M.T.R., J.A.J.V.)."},{"name":"Department of Cardiology, Cardiovascular Research Institute (CARIM), Maastricht University Medical Center, the Netherlands (N.J.B., M.F.G.H.M.V., G.H.J.M.E., S.L.V.M.S., J.A.J.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Paldino","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.A.M., N.J.B., A.P., C.G.-M., D.R.K., M.F.G.H.M.V., E.d.M., F.D., M.D.F., M.M., S.L.V.M.S., G.S., A.S.A., P.G.-P., A.S.J.M.T.R., J.A.J.V.)."},{"name":"Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Italy (A.P., E.d.M., M.D.F., M.M., G.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7772-7726","authenticated-orcid":true,"given":"Clea","family":"Gonzalez-Maniega","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.A.M., N.J.B., A.P., C.G.-M., D.R.K., M.F.G.H.M.V., E.d.M., F.D., M.D.F., M.M., S.L.V.M.S., G.S., A.S.A., P.G.-P., A.S.J.M.T.R., J.A.J.V.)."},{"name":"Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, Health Research Institute of the Puerta de Hierro Majadahonda-Segovia de Arana (IDIPHIM), Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Cardiovasculares (CIBER-CV), and Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (C.G.-M., F.D., P.G.-P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-7049","authenticated-orcid":true,"given":"Henning","family":"Bundgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Denmark (H.B., A.H.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6855-1496","authenticated-orcid":true,"given":"Alex H.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Denmark (H.B., A.H.C.)."},{"name":"Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen, Denmark (A.H.C., C.R.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-206X","authenticated-orcid":true,"given":"Christoffer R.","family":"Vissing","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen, Denmark (A.H.C., C.R.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8979-2096","authenticated-orcid":true,"given":"Renee","family":"Johnson","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Australia (R.J., D.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6427-2521","authenticated-orcid":true,"given":"Daria R.","family":"Kramarenko","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.A.M., N.J.B., A.P., C.G.-M., D.R.K., M.F.G.H.M.V., E.d.M., F.D., M.D.F., M.M., S.L.V.M.S., G.S., A.S.A., P.G.-P., A.S.J.M.T.R., J.A.J.V.)."},{"name":"Department of Experimental Cardiology (D.R.K., A.S.A.), Amsterdam Cardiovascular Sciences, Heart Failure &amp; Arrhythmias, Amsterdam UMC Location, University of Amsterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2574-6672","authenticated-orcid":true,"given":"Max F.G.H.M.","family":"Venner","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.A.M., N.J.B., A.P., C.G.-M., D.R.K., M.F.G.H.M.V., E.d.M., F.D., M.D.F., M.M., S.L.V.M.S., G.S., A.S.A., P.G.-P., A.S.J.M.T.R., J.A.J.V.)."},{"name":"Department of Cardiology, Cardiovascular Research Institute (CARIM), Maastricht University Medical Center, the Netherlands (N.J.B., M.F.G.H.M.V., G.H.J.M.E., S.L.V.M.S., J.A.J.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5432-9288","authenticated-orcid":true,"given":"Eva","family":"del Mestre","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.A.M., N.J.B., A.P., C.G.-M., D.R.K., M.F.G.H.M.V., E.d.M., F.D., M.D.F., M.M., S.L.V.M.S., G.S., A.S.A., P.G.-P., A.S.J.M.T.R., J.A.J.V.)."},{"name":"Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Italy (A.P., E.d.M., M.D.F., M.M., G.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7659-7702","authenticated-orcid":true,"given":"Guilielmus H.J.M.","family":"Ellenbroek","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute (CARIM), Maastricht University Medical Center, the Netherlands (N.J.B., M.F.G.H.M.V., G.H.J.M.E., S.L.V.M.S., J.A.J.V.)."},{"name":"Department of Cardiology (G.H.J.M.E.), Maastricht University Medical Center+, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8408-363X","authenticated-orcid":true,"given":"Fernando","family":"Dominiquez","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.A.M., N.J.B., A.P., C.G.-M., D.R.K., M.F.G.H.M.V., E.d.M., F.D., M.D.F., M.M., S.L.V.M.S., G.S., A.S.A., P.G.-P., A.S.J.M.T.R., J.A.J.V.)."},{"name":"Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, Health Research Institute of the Puerta de Hierro Majadahonda-Segovia de Arana (IDIPHIM), Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Cardiovasculares (CIBER-CV), and Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (C.G.-M., F.D., P.G.-P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2310-0448","authenticated-orcid":true,"given":"Matteo","family":"Dal Ferro","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.A.M., N.J.B., A.P., C.G.-M., D.R.K., M.F.G.H.M.V., E.d.M., F.D., M.D.F., M.M., S.L.V.M.S., G.S., A.S.A., P.G.-P., A.S.J.M.T.R., J.A.J.V.)."},{"name":"Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Italy (A.P., E.d.M., M.D.F., M.M., G.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1022-3131","authenticated-orcid":true,"given":"Marco","family":"Merlo","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.A.M., N.J.B., A.P., C.G.-M., D.R.K., M.F.G.H.M.V., E.d.M., F.D., M.D.F., M.M., S.L.V.M.S., G.S., A.S.A., P.G.-P., A.S.J.M.T.R., J.A.J.V.)."},{"name":"Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Italy (A.P., E.d.M., M.D.F., M.M., G.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0965-6359","authenticated-orcid":true,"given":"Sophie L.V.M.","family":"Stroeks","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.A.M., N.J.B., A.P., C.G.-M., D.R.K., M.F.G.H.M.V., E.d.M., F.D., M.D.F., M.M., S.L.V.M.S., G.S., A.S.A., P.G.-P., A.S.J.M.T.R., J.A.J.V.)."},{"name":"Department of Cardiology, Cardiovascular Research Institute (CARIM), Maastricht University Medical Center, the Netherlands (N.J.B., M.F.G.H.M.V., G.H.J.M.E., S.L.V.M.S., J.A.J.V.)."},{"name":"Department of Clinical Genetics (S.L.V.M.S., J.A.J.V.), Maastricht University Medical Center+, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2700-8478","authenticated-orcid":true,"given":"Gianfranco","family":"Sinagra","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.A.M., N.J.B., A.P., C.G.-M., D.R.K., M.F.G.H.M.V., E.d.M., F.D., M.D.F., M.M., S.L.V.M.S., G.S., A.S.A., P.G.-P., A.S.J.M.T.R., J.A.J.V.)."},{"name":"Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Italy (A.P., E.d.M., M.D.F., M.M., G.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1600-7907","authenticated-orcid":true,"given":"Ahmad S.","family":"Amin","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.A.M., N.J.B., A.P., C.G.-M., D.R.K., M.F.G.H.M.V., E.d.M., F.D., M.D.F., M.M., S.L.V.M.S., G.S., A.S.A., P.G.-P., A.S.J.M.T.R., J.A.J.V.)."},{"name":"Department of Experimental Cardiology (D.R.K., A.S.A.), Amsterdam Cardiovascular Sciences, Heart Failure &amp; Arrhythmias, Amsterdam UMC Location, University of Amsterdam, the Netherlands."},{"name":"Department of Clinical Cardiology (A.S.A.), Amsterdam Cardiovascular Sciences, Heart Failure &amp; Arrhythmias, Amsterdam UMC Location, University of Amsterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9010-9856","authenticated-orcid":true,"given":"Diane","family":"Fatkin","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Australia (R.J., D.F.)."},{"name":"Cardiology Department, St Vincent\u2019s Hospital, Darlinghurst, Australia (D.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5470-2257","authenticated-orcid":true,"given":"Pablo","family":"Garcia-Pavia","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.A.M., N.J.B., A.P., C.G.-M., D.R.K., M.F.G.H.M.V., E.d.M., F.D., M.D.F., M.M., S.L.V.M.S., G.S., A.S.A., P.G.-P., A.S.J.M.T.R., J.A.J.V.)."},{"name":"Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, Health Research Institute of the Puerta de Hierro Majadahonda-Segovia de Arana (IDIPHIM), Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Cardiovasculares (CIBER-CV), and Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (C.G.-M., F.D., P.G.-P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4694-4790","authenticated-orcid":true,"given":"Anneline S.J.M.","family":"Te Riele","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht, the Netherlands (S.A.M., A.S.J.M.T.R.)."},{"name":"Netherlands Heart Institute, Utrecht (S.A.M., A.S.J.M.T.R.)."},{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.A.M., N.J.B., A.P., C.G.-M., D.R.K., M.F.G.H.M.V., E.d.M., F.D., M.D.F., M.M., S.L.V.M.S., G.S., A.S.A., P.G.-P., A.S.J.M.T.R., J.A.J.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-1298","authenticated-orcid":true,"given":"Job A.J.","family":"Verdonschot","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.A.M., N.J.B., A.P., C.G.-M., D.R.K., M.F.G.H.M.V., E.d.M., F.D., M.D.F., M.M., S.L.V.M.S., G.S., A.S.A., P.G.-P., A.S.J.M.T.R., J.A.J.V.)."},{"name":"Department of Cardiology, Cardiovascular Research Institute (CARIM), Maastricht University Medical Center, the Netherlands (N.J.B., M.F.G.H.M.V., G.H.J.M.E., S.L.V.M.S., J.A.J.V.)."},{"name":"Department of Clinical Genetics (S.L.V.M.S., J.A.J.V.), Maastricht University Medical Center+, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2013.105"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad194"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110186"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.124.004778"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-024-01924-1"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.24674"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2022.07.009"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.123.016090"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.05.005"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.125.074058"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.02.036"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10050921"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.024947"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1129348"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf571"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.3339"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000455"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv727"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.11.022"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2017.03.003"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu050"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.03.462"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2024.08.011"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.03.419"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2023.08.003"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf380"}],"container-title":["Circulation: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCHEARTFAILURE.125.013822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:00:20Z","timestamp":1789981220000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCHEARTFAILURE.125.013822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":27,"alternative-id":["10.1161\/CIRCHEARTFAILURE.125.013822"],"URL":"https:\/\/doi.org\/10.1161\/circheartfailure.125.013822","relation":{},"ISSN":["1941-3289","1941-3297"],"issn-type":[{"value":"1941-3289","type":"print"},{"value":"1941-3297","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]},"assertion":[{"value":"2025-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e013822"}}