{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:56:24Z","timestamp":1792151784230,"version":"4.4.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Heart Failure"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>There is a growing consensus that screening for subclinical preheart failure (HF) may reduce the burden of symptomatic HF by allowing for timely preventive interventions. However, validated screening algorithms are currently lacking. The aim of this study was to evaluate a fully mobile telemedically supervised cardiac magnetic resonance, as a simple standardized, and ubiquitously applicable screening algorithm for subclinical pre-HF in rural and underresourced regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>HERZCHECK was a cross-sectional cohort study conducted at 12 sites across rural and underresourced regions of Germany. Asymptomatic participants (40\u201369 years) with \u22651 cardiovascular risk factor\u2014obesity, smoking, arterial hypertension, diabetes, hypercholesterolemia, or chronic kidney disease\u2014were enrolled and underwent telemedically supervised contrast-free short cardiac magnetic resonance in mobile screening units. Subclinical pre-HF was diagnosed using a predefined cutoff of global longitudinal strain \u2265\u221215%. A matched and entropy-balanced control cohort constructed from claims data was used to determine the time difference between detection of subclinical pre-HF in HERZCHECK and the first symptom-based diagnosis of HF within the standard of care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Between June 2021 and April 2023, 4666 participants were enrolled in the study, of which 4509 participants were included in the final analysis. The prevalence of subclinical pre-HF in the studied at-risk population was 22.7% (95% CI, 21.5%\u201323.9%). Global longitudinal strain-based screening identified subclinical pre-HF 6.7 years before the average onset of symptomatic HF within the standard of care (n=8420).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Subclinical pre-HF affects approximately one-fourth of the at-risk population in rural and underresourced regions. The HERZCHECK approach identifies patients suitable for targeted preventive interventions \u22487 years earlier than the standard of care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT05122793.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circheartfailure.125.013935","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:00:41Z","timestamp":1784019641000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["HERZCHECK: Early Detection of Subclinical Heart Failure Using Mobile Cardiac Magnetic Resonance and Telemedicine in Rural and Underressourced Regions"],"prefix":"10.1161","volume":"19","clinical-trial-number":[{"clinical-trial-number":"nct05122793","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8105-6599","authenticated-orcid":true,"given":"Sebastian","family":"Kelle","sequence":"first","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine (S.K., M.L.M., R.E.B., G.T., A.C.N., A.T., M.C., P.D., U.E.W., B.P., U.L.), Deutsches Herzzentrum der Charit\u00e9, Berlin, Germany."},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Germany (S.K., M.L.M., R.E.B., G.T., A.C.N., A.T., M.C., P.D., U.E.W., S. Schmidt, V.F.)."},{"name":"DZHK (German Centre for Cardiovascular Research), Berlin, Germany (S.K., M.L.M., R.E.B., A.C.N., P.D., V.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6281-9754","authenticated-orcid":true,"given":"Maximilian Leo","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine (S.K., M.L.M., R.E.B., G.T., A.C.N., A.T., M.C., P.D., U.E.W., B.P., U.L.), Deutsches Herzzentrum der Charit\u00e9, Berlin, Germany."},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Germany (S.K., M.L.M., R.E.B., G.T., A.C.N., A.T., M.C., P.D., U.E.W., S. Schmidt, V.F.)."},{"name":"DZHK (German Centre for Cardiovascular Research), Berlin, Germany (S.K., M.L.M., R.E.B., A.C.N., P.D., V.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9373-0756","authenticated-orcid":true,"given":"Rebecca Elisabeth","family":"Beyer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine (S.K., M.L.M., R.E.B., G.T., A.C.N., A.T., M.C., P.D., U.E.W., B.P., U.L.), Deutsches Herzzentrum der Charit\u00e9, Berlin, Germany."},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Germany (S.K., M.L.M., R.E.B., G.T., A.C.N., A.T., M.C., P.D., U.E.W., S. Schmidt, V.F.)."},{"name":"DZHK (German Centre for Cardiovascular Research), Berlin, Germany (S.K., M.L.M., R.E.B., A.C.N., P.D., V.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7023-4218","authenticated-orcid":true,"given":"Gisela","family":"Thiede","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine (S.K., M.L.M., R.E.B., G.T., A.C.N., A.T., M.C., P.D., U.E.W., B.P., U.L.), Deutsches Herzzentrum der Charit\u00e9, Berlin, Germany."},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Germany (S.K., M.L.M., R.E.B., G.T., A.C.N., A.T., M.C., P.D., U.E.W., S. 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Schmidt, V.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Cvetkovic","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine (S.K., M.L.M., R.E.B., G.T., A.C.N., A.T., M.C., P.D., U.E.W., B.P., U.L.), Deutsches Herzzentrum der Charit\u00e9, Berlin, Germany."},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Germany (S.K., M.L.M., R.E.B., G.T., A.C.N., A.T., M.C., P.D., U.E.W., S. 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Schmidt, V.F.)."},{"name":"Herzinstitut Berlin, Kardiologische Gemeinschaftspraxis, Germany (U.E.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1428-2611","authenticated-orcid":true,"given":"Florian","family":"Andr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg\/Mannheim, Germany (H.S., F.A., N.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sein","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Germany (S.K., M.L.M., R.E.B., G.T., A.C.N., A.T., M.C., P.D., U.E.W., S. Schmidt, V.F.)."},{"name":"Berlin Institute of Health (BIH) at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Germany (S. 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