{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:45:13Z","timestamp":1762098313321},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            The sequence of left ventricular (LV) systolic emptying is not completely understood. Using real-time 3-dimensional echocardiography, we investigated this sequence and LV synchronicity in physiological and pathological conditions.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            The study population consisted of 116 healthy volunteers, 20 top-level athletes, 35 patients with LV dysfunction, and 84 patients with LV dysfunction and left bundle-branch block (LBBB). We subdivided the LV into 16 volumetric segments for regional analysis and into apical, middle, and basal regions to calculate the mean of end-systolic times and the time to minimum systolic volume of each region. In healthy volunteers and in top-level athletes, the emptying systolic times increased smoothly from apex to base. These differences determined an apex-to-base time gradient in the LV emptying sequence. In patients with LV dysfunction and without LBBB, this gradient was maintained with a relatively higher LV dyssynchrony. However, in patients with LV dysfunction and LBBB, there was no clear sequence in LV emptying volumes, and this group had the highest LV dyssynchrony.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Real-time 3-dimensional echocardiography tomographic slicing of the LV enables accurate analysis of LV emptying in physiological conditions and in conditions of LV dysfunction with and without electrical dyssynchrony. Progressive dilation of LV produces deterioration in LV synchronicity. However, it is the presence of LV dysfunction in combination with LBBB that determines the loss of the apex-to-base time gradient in LV emptying.\n          <\/jats:p>","DOI":"10.1161\/circimaging.107.763110","type":"journal-article","created":{"date-parts":[[2008,7,23]],"date-time":"2008-07-23T22:01:39Z","timestamp":1216850499000},"page":"41-49","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Tomographic Left Ventricular Volumetric Emptying Analysis by Real-Time 3-Dimensional Echocardiography"],"prefix":"10.1161","volume":"1","author":[{"given":"Stefano","family":"De Castro","sequence":"first","affiliation":[{"name":"From La Sapienza, University of Rome, Rome, Italy (S.D.C., A.M., M.F., D.C., F.M., C.G., S.C., I.C); Cardiocentro Ticino, Lugano, Switzerland (F.F., C.C., A.A.); Department of Public Health and Primary Care, University of Cambridge, Cambridge, England (E.D.A.); and Tufts\u2013New England Medical Center, Boston, Mass (N.G.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Faletra","sequence":"additional","affiliation":[{"name":"From La Sapienza, University of Rome, Rome, Italy (S.D.C., A.M., M.F., D.C., F.M., C.G., S.C., I.C); Cardiocentro Ticino, Lugano, Switzerland (F.F., C.C., A.A.); Department of Public Health and Primary Care, University of Cambridge, Cambridge, England (E.D.A.); and Tufts\u2013New England Medical Center, Boston, Mass (N.G.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Di Angelantonio","sequence":"additional","affiliation":[{"name":"From La Sapienza, University of Rome, Rome, Italy (S.D.C., A.M., M.F., D.C., F.M., C.G., S.C., I.C); Cardiocentro Ticino, Lugano, Switzerland (F.F., C.C., A.A.); Department of Public Health and Primary Care, University of Cambridge, Cambridge, England (E.D.A.); and Tufts\u2013New England Medical Center, Boston, Mass (N.G.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Conca","sequence":"additional","affiliation":[{"name":"From La Sapienza, University of Rome, Rome, Italy (S.D.C., A.M., M.F., D.C., F.M., C.G., S.C., I.C); Cardiocentro Ticino, Lugano, Switzerland (F.F., C.C., A.A.); Department of Public Health and Primary Care, University of Cambridge, Cambridge, England (E.D.A.); and Tufts\u2013New England Medical Center, Boston, Mass (N.G.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Marcantonio","sequence":"additional","affiliation":[{"name":"From La Sapienza, University of Rome, Rome, Italy (S.D.C., A.M., M.F., D.C., F.M., C.G., S.C., I.C); Cardiocentro Ticino, Lugano, Switzerland (F.F., C.C., A.A.); Department of Public Health and Primary Care, University of Cambridge, Cambridge, England (E.D.A.); and Tufts\u2013New England Medical Center, Boston, Mass (N.G.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Francone","sequence":"additional","affiliation":[{"name":"From La Sapienza, University of Rome, Rome, Italy (S.D.C., A.M., M.F., D.C., F.M., C.G., S.C., I.C); Cardiocentro Ticino, Lugano, Switzerland (F.F., C.C., A.A.); Department of Public Health and Primary Care, University of Cambridge, Cambridge, England (E.D.A.); and Tufts\u2013New England Medical Center, Boston, Mass (N.G.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Cartoni","sequence":"additional","affiliation":[{"name":"From La Sapienza, University of Rome, Rome, Italy (S.D.C., A.M., M.F., D.C., F.M., C.G., S.C., I.C); Cardiocentro Ticino, Lugano, Switzerland (F.F., C.C., A.A.); Department of Public Health and Primary Care, University of Cambridge, Cambridge, England (E.D.A.); and Tufts\u2013New England Medical Center, Boston, Mass (N.G.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Mirabelli","sequence":"additional","affiliation":[{"name":"From La Sapienza, University of Rome, Rome, Italy (S.D.C., A.M., M.F., D.C., F.M., C.G., S.C., I.C); Cardiocentro Ticino, Lugano, Switzerland (F.F., C.C., A.A.); Department of Public Health and Primary Care, University of Cambridge, Cambridge, England (E.D.A.); and Tufts\u2013New England Medical Center, Boston, Mass (N.G.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Gaudio","sequence":"additional","affiliation":[{"name":"From La Sapienza, University of Rome, Rome, Italy (S.D.C., A.M., M.F., D.C., F.M., C.G., S.C., I.C); Cardiocentro Ticino, Lugano, Switzerland (F.F., C.C., A.A.); Department of Public Health and Primary Care, University of Cambridge, Cambridge, England (E.D.A.); and Tufts\u2013New England Medical Center, Boston, Mass (N.G.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Caselli","sequence":"additional","affiliation":[{"name":"From La Sapienza, University of Rome, Rome, Italy (S.D.C., A.M., M.F., D.C., F.M., C.G., S.C., I.C); Cardiocentro Ticino, Lugano, Switzerland (F.F., C.C., A.A.); Department of Public Health and Primary Care, University of Cambridge, Cambridge, England (E.D.A.); and Tufts\u2013New England Medical Center, Boston, Mass (N.G.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iacopo","family":"Carbone","sequence":"additional","affiliation":[{"name":"From La Sapienza, University of Rome, Rome, Italy (S.D.C., A.M., M.F., D.C., F.M., C.G., S.C., I.C); Cardiocentro Ticino, Lugano, Switzerland (F.F., C.C., A.A.); Department of Public Health and Primary Care, University of Cambridge, Cambridge, England (E.D.A.); and Tufts\u2013New England Medical Center, Boston, Mass (N.G.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Auricchio","sequence":"additional","affiliation":[{"name":"From La Sapienza, University of Rome, Rome, Italy (S.D.C., A.M., M.F., D.C., F.M., C.G., S.C., I.C); Cardiocentro Ticino, Lugano, Switzerland (F.F., C.C., A.A.); Department of Public Health and Primary Care, University of Cambridge, Cambridge, England (E.D.A.); and Tufts\u2013New England Medical Center, Boston, Mass (N.G.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natesa G.","family":"Pandian","sequence":"additional","affiliation":[{"name":"From La Sapienza, University of Rome, Rome, Italy (S.D.C., A.M., M.F., D.C., F.M., C.G., S.C., I.C); Cardiocentro Ticino, Lugano, Switzerland (F.F., C.C., A.A.); Department of Public Health and Primary Care, University of Cambridge, Cambridge, England (E.D.A.); and Tufts\u2013New England Medical Center, Boston, Mass (N.G.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1053\/euje.2000.0031"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2003.10.001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.102.10.1158"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2006.08.031"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.10.040"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000019907.77526.75"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"S150","DOI":"10.1016\/j.ejcts.2006.02.066","volume":"29","year":"2006","unstructured":"Jung B, Markl M, Foll D, Henning J. Investigating myocardial motion by MRI using tissue phase mapping. Eur J Cardiothorac Surg. 2006; 29S: S150\u2013S157.","journal-title":"Eur J Cardiothorac Surg"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00867.2004"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2002.282.1.H372"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01053.2003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.21.4.423"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.45.3.248"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600520103"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.113745"},{"key":"e_1_3_2_15_2","first-page":"H1072","volume":"283","year":"2002","unstructured":"Vendelin M, Bovendeerd PH, Engelbrecht J, Arts T. Optimizing ventricular fibers: uniform strain or stress, but not ATP consumption, leads to high efficiency. Am J Physiol. 2002; 283: H1072\u2013H1081.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000199396.30688.eb"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2002.00484.x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.058388"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.047"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.626143"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2006.04.012"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(89)80014-8"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.60.3.455617"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.104.474445"},{"key":"e_1_3_2_25_2","first-page":"205","volume":"93","year":"2007","unstructured":"De Castro S, Caselli S, Maron M, Pelliccia A, Cavarretta E, Maddukuri P, Cartoni D, Di Angelantonio E, Kuvin JT, Patel AR, Pandian NG. Left ventricular remodelling index (LVRI) in various patho-physiologic conditions: a real-time three-dimensional echocardiographic study. Heart. 2007; 93: 205\u2013209.","journal-title":"Heart"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.096040"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.104.508457"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2002.01203.x"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.105.4.438"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.019"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.08.073"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.02.082"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.12.063"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"S150","DOI":"10.1016\/j.ejcts.2006.02.066","volume":"29","year":"2006","unstructured":"Jung B, Markl M, Foll D, Henning J. Investigating myocardial motion by using MRI tissue phase mapping. Eur J Cardiothorac Surg. 2006; 29S: S150\u2013S157.","journal-title":"Eur J Cardiothorac Surg"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.169.1.3420283"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-199412000-00005"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.107.763110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:34:22Z","timestamp":1715564062000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.107.763110"}},"subtitle":["Influence of Left Ventricular Dysfunction With and Without Electrical Dyssynchrony"],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1161\/CIRCIMAGING.107.763110"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.107.763110","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7]]},"assertion":[{"value":"2008-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}