{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:22:13Z","timestamp":1791534133284,"version":"4.3.4"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The etiology of ventricular dysfunction in adult congenital heart disease (ACHD) is not well understood. Diffuse fibrosis is a likely common final pathway and is quantifiable using MRI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Patients with ACHD (n=50) were studied with cardiac MRI to quantify systemic ventricular volume and function and diffuse fibrosis. The fibrosis index for a single midventricular plane of the systemic ventricle was quantified by measuring T1 values for blood pool and myocardium before and after administration of gadolinium (0.15 mmol\/kg) and then adjusted for hematocrit. Results were compared to healthy volunteers (normal controls, n=14) and patients with acquired heart failure (positive controls, n=4). Patients studied (age, 37\u00b112 years; female sex, 40%) included 11 with a systemic right ventricle (RV), 17 with tetralogy of Fallot, 10 with cyanosis, and 12 with other lesions. The fibrosis index was significantly elevated in patients with ACHD compared to normal controls (31.9\u00b14.9% versus 24.8\u00b12.0%;\n              <jats:italic>P<\/jats:italic>\n              =0.001). Values were highest in patients with a systemic RV (35.0\u00b15.8%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and those who were cyanotic (33.7\u00b15.6%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The fibrosis index correlated with end-diastolic volume index (\n              <jats:italic>r<\/jats:italic>\n              =0.60;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and ventricular ejection fraction (\n              <jats:italic>r<\/jats:italic>\n              =\u22120.53;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) but not with age or oxygen saturation in patients who were cyanotic. Late gadolinium enhancement did not account for the differences seen.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Patients with ACHD have evidence of diffuse, extracellular matrix remodeling similar to patients with acquired heart failure. The fibrosis index may facilitate studies on the mechanisms and treatment of myocardial fibrosis and heart failure in these patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.108.842096","type":"journal-article","created":{"date-parts":[[2010,9,21]],"date-time":"2010-09-21T04:51:31Z","timestamp":1285044691000},"page":"727-734","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":240,"title":["Quantification of Diffuse Myocardial Fibrosis and Its Association With Myocardial Dysfunction in Congenital Heart Disease"],"prefix":"10.1161","volume":"3","author":[{"given":"Craig S.","family":"Broberg","sequence":"first","affiliation":[{"name":"From the Adult Congenital Heart Disease Program (C.S.B., D.J.S.); Division of Cardiology (C.S.B., S.S.C.); Department of Radiology (C.C., M.J.-H.); and Division of Pediatric Cardiology (D.J.S.), Oregon Health and Science University, Portland, Ore; Division of Cardiology; Cedar-Sinai Medical Center; Los Angeles, Calif; and Department of Radiology (M.J.-H.), Brigham and Women's Hospital, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeet S.","family":"Chugh","sequence":"additional","affiliation":[{"name":"From the Adult Congenital Heart Disease Program (C.S.B., D.J.S.); Division of Cardiology (C.S.B., S.S.C.); Department of Radiology (C.C., M.J.-H.); and Division of Pediatric Cardiology (D.J.S.), Oregon Health and Science University, Portland, Ore; Division of Cardiology; Cedar-Sinai Medical Center; Los Angeles, Calif; and Department of Radiology (M.J.-H.), Brigham and Women's Hospital, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Conklin","sequence":"additional","affiliation":[{"name":"From the Adult Congenital Heart Disease Program (C.S.B., D.J.S.); Division of Cardiology (C.S.B., S.S.C.); Department of Radiology (C.C., M.J.-H.); and Division of Pediatric Cardiology (D.J.S.), Oregon Health and Science University, Portland, Ore; Division of Cardiology; Cedar-Sinai Medical Center; Los Angeles, Calif; and Department of Radiology (M.J.-H.), Brigham and Women's Hospital, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Sahn","sequence":"additional","affiliation":[{"name":"From the Adult Congenital Heart Disease Program (C.S.B., D.J.S.); Division of Cardiology (C.S.B., S.S.C.); Department of Radiology (C.C., M.J.-H.); and Division of Pediatric Cardiology (D.J.S.), Oregon Health and Science University, Portland, Ore; Division of Cardiology; Cedar-Sinai Medical Center; Los Angeles, Calif; and Department of Radiology (M.J.-H.), Brigham and Women's Hospital, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Jerosch-Herold","sequence":"additional","affiliation":[{"name":"From the Adult Congenital Heart Disease Program (C.S.B., D.J.S.); Division of Cardiology (C.S.B., S.S.C.); Department of Radiology (C.C., M.J.-H.); and Division of Pediatric Cardiology (D.J.S.), Oregon Health and Science University, Portland, Ore; Division of Cardiology; Cedar-Sinai Medical Center; Los Angeles, Calif; and Department of Radiology (M.J.-H.), Brigham and Women's Hospital, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00005-8"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.627224"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01272-4"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.05.040"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.6.1849"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2002.2088"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.03.062"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.571653"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000138680.89536.A9"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01965-4"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411001"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.3317\/jraas.2006.001"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(63)90138-8"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.51.1.39"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(77)80221-X"},{"key":"e_1_3_4_17_2","first-page":"501","article-title":"Myocardial ultrastructure in children and adults with congenital heart disease","volume":"10","author":"Jones M","year":"1979","unstructured":"Jones M, Ferrans VJ. Myocardial ultrastructure in children and adults with congenital heart disease. Cardiovasc Clin. 1979;10:501\u2013530.","journal-title":"Cardiovasc Clin"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.04.001"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000162463.61626.3b"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.548727"},{"key":"e_1_3_4_21_2","first-page":"263A","article-title":"The interventricular relationship with Eisenmenger syndrome: findings with cardiac magnetic resonance and late gadolinium enhancement [abstract]","volume":"49","author":"Broberg CS","year":"2007","unstructured":"Broberg CS, Prasad SK, Gatzoulis MA. The interventricular relationship with Eisenmenger syndrome: findings with cardiac magnetic resonance and late gadolinium enhancement [abstract]. J Am Coll Cardiol. 2007;49:263A.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2373041324"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2006.00035.x"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2382041903"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20110"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.06.049"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2007.10.003"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00429.2008"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-007-9223-y"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1684482"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.218.3.r01fe18703"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910380406"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000020009.30736.3F"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.529800"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.08.010"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20236"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000152819.97857.9D"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.049"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.025304"},{"key":"e_1_3_4_40_2","first-page":"154","article-title":"Cardiac magnetic resonance contrast enhancement differentiates patients affected with familial dilated cardiomyopathy from asymptomatic relatives","volume":"8","author":"Jerosch-Herold M","year":"2006","unstructured":"Jerosch-Herold M, Sheridan D, Kushner J, Nauman D, Burgess D, Dutton D, Hershberger R. Cardiac magnetic resonance contrast enhancement differentiates patients affected with familial dilated cardiomyopathy from asymptomatic relatives. J Cardiovasc Magn Reson. 2006;8:154\u2013155.","journal-title":"J Cardiovasc Magn Reson"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.104745"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.10.045"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.543470"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.08.006"},{"key":"e_1_3_4_45_2","volume-title":"Oral presentation to the International Symposium on Adult Congenital Heart Disease","author":"Babu-Narayan S","unstructured":"Babu-Narayan S, Uebing A, Davlouros PA, Path MK, Davidson S, Bayne S, Dimopoulos K, Pennell DJ, Gibson DG, Kilner PJ, Li W, Gatzoulis MA. Potential therapeutic role of ACE inhibitors in repaired tetralogy of Fallot and pulmonary regurgitation\u2014the appropriate study (ACE inhibitors for potential prevention of the deleterious effects of pulmonary regurgitation in adults with repaired tetralogy of Fallot). Oral presentation to the International Symposium on Adult Congenital Heart Disease; June 5 2008; Toronto, CA."}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.108.842096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:40:33Z","timestamp":1715564433000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.108.842096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1161\/CIRCIMAGING.108.842096"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.108.842096","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"2009-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-08-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-09-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}