{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:52:07Z","timestamp":1783684327343,"version":"3.55.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Central obesity is associated with peripheral arterial disease, suggesting that ectopic fat depots may be associated with localized diseases of the aorta and lower-extremity arteries. We hypothesized that persons with greater amounts of periaortic fat are more likely to have clinical PAD and a low ankle-brachial index.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We quantified periaortic fat surrounding the thoracic aorta using a novel volumetric quantitative approach in 1205 participants from the Framingham Heart Study Offspring cohort (mean age, 65.9 years; women, 54%); visceral abdominal fat also was measured. Clinical peripheral arterial disease was defined as a history of intermittent claudication, and ankle-brachial index was dichotomized as low (\u22640.9) or lower-extremity revascularization versus normal (&gt;0.9 to &lt;1.4). Regression models were created to examine the association between periaortic fat and intermittent claudication or low ankle-brachial index (n=66). In multivariable logistic regression, per 1 SD increase in periaortic fat, the odds ratio for the combined end point was 1.52 (\n              <jats:italic>P<\/jats:italic>\n              =0.004); these results were strengthened with additional adjustment for body mass index (odds ratio, 1.69;\n              <jats:italic>P<\/jats:italic>\n              =0.002) or visceral abdominal fat (odds ratio, 1.67;\n              <jats:italic>P<\/jats:italic>\n              =0.009), whereas no association was observed for visceral abdominal fat (\n              <jats:italic>P<\/jats:italic>\n              =0.16). Similarly, per SD increase in body mass index or waist circumference, no association was observed after accounting for visceral abdominal fat (body mass index,\n              <jats:italic>P<\/jats:italic>\n              =0.35; waist circumference,\n              <jats:italic>P<\/jats:italic>\n              =0.49).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Periaortic fat is associated with low ABI and intermittent claudication.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.110.958884","type":"journal-article","created":{"date-parts":[[2010,7,17]],"date-time":"2010-07-17T00:25:31Z","timestamp":1279326331000},"page":"515-519","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":83,"title":["Periaortic Fat Deposition Is Associated With Peripheral Arterial Disease"],"prefix":"10.1161","volume":"3","author":[{"given":"Caroline S.","family":"Fox","sequence":"first","affiliation":[{"name":"From the National Heart, Lung, and Blood Institute Framingham Heart Study (C.S.F., C.J.O., J.M. Murabito), Bethesda, Md, and Framingham, Mass; Departments of Cardiac MR PET CT (C.L.S., S.J.L, U.H.) and General Internal Medicine (J.M. Murabito), Massachusetts General Hospital and Harvard Medical School, Boston Mass; Department of Cardiology (S.J.L.), Flinders University, Adelaide, Australia; Department of Mathematics (J.M. Massaro), Boston University, Boston, Mass; Division of Endocrinology (C.S.F.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Massaro","sequence":"additional","affiliation":[{"name":"From the National Heart, Lung, and Blood Institute Framingham Heart Study (C.S.F., C.J.O., J.M. Murabito), Bethesda, Md, and Framingham, Mass; Departments of Cardiac MR PET CT (C.L.S., S.J.L, U.H.) and General Internal Medicine (J.M. Murabito), Massachusetts General Hospital and Harvard Medical School, Boston Mass; Department of Cardiology (S.J.L.), Flinders University, Adelaide, Australia; Department of Mathematics (J.M. Massaro), Boston University, Boston, Mass; Division of Endocrinology (C.S.F.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Schlett","sequence":"additional","affiliation":[{"name":"From the National Heart, Lung, and Blood Institute Framingham Heart Study (C.S.F., C.J.O., J.M. Murabito), Bethesda, Md, and Framingham, Mass; Departments of Cardiac MR PET CT (C.L.S., S.J.L, U.H.) and General Internal Medicine (J.M. Murabito), Massachusetts General Hospital and Harvard Medical School, Boston Mass; Department of Cardiology (S.J.L.), Flinders University, Adelaide, Australia; Department of Mathematics (J.M. Massaro), Boston University, Boston, Mass; Division of Endocrinology (C.S.F.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam J.","family":"Lehman","sequence":"additional","affiliation":[{"name":"From the National Heart, Lung, and Blood Institute Framingham Heart Study (C.S.F., C.J.O., J.M. Murabito), Bethesda, Md, and Framingham, Mass; Departments of Cardiac MR PET CT (C.L.S., S.J.L, U.H.) and General Internal Medicine (J.M. Murabito), Massachusetts General Hospital and Harvard Medical School, Boston Mass; Department of Cardiology (S.J.L.), Flinders University, Adelaide, Australia; Department of Mathematics (J.M. Massaro), Boston University, Boston, Mass; Division of Endocrinology (C.S.F.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Meigs","sequence":"additional","affiliation":[{"name":"From the National Heart, Lung, and Blood Institute Framingham Heart Study (C.S.F., C.J.O., J.M. Murabito), Bethesda, Md, and Framingham, Mass; Departments of Cardiac MR PET CT (C.L.S., S.J.L, U.H.) and General Internal Medicine (J.M. Murabito), Massachusetts General Hospital and Harvard Medical School, Boston Mass; Department of Cardiology (S.J.L.), Flinders University, Adelaide, Australia; Department of Mathematics (J.M. Massaro), Boston University, Boston, Mass; Division of Endocrinology (C.S.F.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"O'Donnell","sequence":"additional","affiliation":[{"name":"From the National Heart, Lung, and Blood Institute Framingham Heart Study (C.S.F., C.J.O., J.M. Murabito), Bethesda, Md, and Framingham, Mass; Departments of Cardiac MR PET CT (C.L.S., S.J.L, U.H.) and General Internal Medicine (J.M. Murabito), Massachusetts General Hospital and Harvard Medical School, Boston Mass; Department of Cardiology (S.J.L.), Flinders University, Adelaide, Australia; Department of Mathematics (J.M. Massaro), Boston University, Boston, Mass; Division of Endocrinology (C.S.F.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"From the National Heart, Lung, and Blood Institute Framingham Heart Study (C.S.F., C.J.O., J.M. Murabito), Bethesda, Md, and Framingham, Mass; Departments of Cardiac MR PET CT (C.L.S., S.J.L, U.H.) and General Internal Medicine (J.M. Murabito), Massachusetts General Hospital and Harvard Medical School, Boston Mass; Department of Cardiology (S.J.L.), Flinders University, Adelaide, Australia; Department of Mathematics (J.M. Massaro), Boston University, Boston, Mass; Division of Endocrinology (C.S.F.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne M.","family":"Murabito","sequence":"additional","affiliation":[{"name":"From the National Heart, Lung, and Blood Institute Framingham Heart Study (C.S.F., C.J.O., J.M. Murabito), Bethesda, Md, and Framingham, Mass; Departments of Cardiac MR PET CT (C.L.S., S.J.L, U.H.) and General Internal Medicine (J.M. Murabito), Massachusetts General Hospital and Harvard Medical School, Boston Mass; Department of Cardiology (S.J.L.), Flinders University, Adelaide, Australia; Department of Mathematics (J.M. 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