{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:13:45Z","timestamp":1767651225024},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Carotid intraplaque hemorrhage has been associated with symptomatic stroke and can be accurately detected with magnetization-prepared rapid acquisition with gradient-echo (MPRAGE). Currently, there are no studies analyzing carotid MPRAGE signal and territorial ischemic events defined by diffusion restriction in the acute setting. Our aim was to determine the association of carotid MPRAGE signal with acute territorial ischemic events using carotid MPRAGE and brain diffusion tensor imaging.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              After the addition of the MPRAGE sequence to the neck MR angiographic protocol, 159 patients with suspected acute stroke were evaluated with both brain diffusion tensor imaging and carotid MPRAGE sequences over 2 years, providing 318 carotid artery and paired brain images for analysis. Forty-eight arteries were excluded due to extracarotid sources of brain ischemia and 4 were excluded due to carotid occlusion. Two hundred sixty-six arteries were eligible for data analysis. Carotid MPRAGE-positive signal was associated with an acute cerebral territorial ischemic event with a relative risk of 6.4 (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The relative risk of a diffusion tensor imaging-positive territorial ischemic event with carotid MPRAGE-positive signal was increased in mild, moderate, and severe stenosis categories (10.3,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; 2.9,\n              <jats:italic>P<\/jats:italic>\n              =0.01; and 2.2,\n              <jats:italic>P<\/jats:italic>\n              =0.01, respectively).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In the workup of acute stroke, carotid MPRAGE-positive signal was associated with an increased risk of territorial cerebral ischemic events as detected objectively by brain diffusion tensor imaging. The relative risk of stroke was increased in all carotid stenosis categories but was most elevated in the mild stenosis category.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.111.967398","type":"journal-article","created":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T05:46:53Z","timestamp":1334209613000},"page":"376-382","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Carotid Magnetization-Prepared Rapid Acquisition With Gradient-Echo Signal Is Associated With Acute Territorial Cerebral Ischemic Events Detected by Diffusion-Weighted MRI"],"prefix":"10.1161","volume":"5","author":[{"given":"J. Scott","family":"McNally","sequence":"first","affiliation":[{"name":"From the Department of Radiology, Utah Center for Advanced Imaging Research, University of Utah School of Medicine, Salt Lake City, UT (J.S.M., S.-E.K., J.A.R., D.L.P., G.S.T.); the Department of Diagnostic Imaging, Kaiser Permanente, Honolulu, HI (H.-C.Y.); the Department of Radiology, University of California, Irvine, CA (L.K.F.); the Departments of Pathology and Surgery, VA Salt Lake City Health Care System, Salt Lake City, UT (D.R.N., G.S.T.); and the Departments of Pathology and Surgery,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Utah Center for Advanced Imaging Research, University of Utah School of Medicine, Salt Lake City, UT (J.S.M., S.-E.K., J.A.R., D.L.P., G.S.T.); the Department of Diagnostic Imaging, Kaiser Permanente, Honolulu, HI (H.-C.Y.); the Department of Radiology, University of California, Irvine, CA (L.K.F.); the Departments of Pathology and Surgery, VA Salt Lake City Health Care System, Salt Lake City, UT (D.R.N., G.S.T.); and the Departments of Pathology and Surgery,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Chun","family":"Yoon","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Utah Center for Advanced Imaging Research, University of Utah School of Medicine, Salt Lake City, UT (J.S.M., S.-E.K., J.A.R., D.L.P., G.S.T.); the Department of Diagnostic Imaging, Kaiser Permanente, Honolulu, HI (H.-C.Y.); the Department of Radiology, University of California, Irvine, CA (L.K.F.); the Departments of Pathology and Surgery, VA Salt Lake City Health Care System, Salt Lake City, UT (D.R.N., G.S.T.); and the Departments of Pathology and Surgery,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura K.","family":"Findeiss","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Utah Center for Advanced Imaging Research, University of Utah School of Medicine, Salt Lake City, UT (J.S.M., S.-E.K., J.A.R., D.L.P., G.S.T.); the Department of Diagnostic Imaging, Kaiser Permanente, Honolulu, HI (H.-C.Y.); the Department of Radiology, University of California, Irvine, CA (L.K.F.); the Departments of Pathology and Surgery, VA Salt Lake City Health Care System, Salt Lake City, UT (D.R.N., G.S.T.); and the Departments of Pathology and Surgery,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Roberts","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Utah Center for Advanced Imaging Research, University of Utah School of Medicine, Salt Lake City, UT (J.S.M., S.-E.K., J.A.R., D.L.P., G.S.T.); the Department of Diagnostic Imaging, Kaiser Permanente, Honolulu, HI (H.-C.Y.); the Department of Radiology, University of California, Irvine, CA (L.K.F.); the Departments of Pathology and Surgery, VA Salt Lake City Health Care System, Salt Lake City, UT (D.R.N., G.S.T.); and the Departments of Pathology and Surgery,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R.","family":"Nightingale","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Utah Center for Advanced Imaging Research, University of Utah School of Medicine, Salt Lake City, UT (J.S.M., S.-E.K., J.A.R., D.L.P., G.S.T.); the Department of Diagnostic Imaging, Kaiser Permanente, Honolulu, HI (H.-C.Y.); the Department of Radiology, University of California, Irvine, CA (L.K.F.); the Departments of Pathology and Surgery, VA Salt Lake City Health Care System, Salt Lake City, UT (D.R.N., G.S.T.); and the Departments of Pathology and Surgery,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna K.","family":"Narra","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Utah Center for Advanced Imaging Research, University of Utah School of Medicine, Salt Lake City, UT (J.S.M., S.-E.K., J.A.R., D.L.P., G.S.T.); the Department of Diagnostic Imaging, Kaiser Permanente, Honolulu, HI (H.-C.Y.); the Department of Radiology, University of California, Irvine, CA (L.K.F.); the Departments of Pathology and Surgery, VA Salt Lake City Health Care System, Salt Lake City, UT (D.R.N., G.S.T.); and the Departments of Pathology and Surgery,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis L.","family":"Parker","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Utah Center for Advanced Imaging Research, University of Utah School of Medicine, Salt Lake City, UT (J.S.M., S.-E.K., J.A.R., D.L.P., G.S.T.); the Department of Diagnostic Imaging, Kaiser Permanente, Honolulu, HI (H.-C.Y.); the Department of Radiology, University of California, Irvine, CA (L.K.F.); the Departments of Pathology and Surgery, VA Salt Lake City Health Care System, Salt Lake City, UT (D.R.N., G.S.T.); and the Departments of Pathology and Surgery,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald S.","family":"Treiman","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Utah Center for Advanced Imaging Research, University of Utah School of Medicine, Salt Lake City, UT (J.S.M., S.-E.K., J.A.R., D.L.P., G.S.T.); the Department of Diagnostic Imaging, Kaiser Permanente, Honolulu, HI (H.-C.Y.); the Department of Radiology, University of California, Irvine, CA (L.K.F.); the Departments of Pathology and Surgery, VA Salt Lake City Health Care System, Salt Lake City, UT (D.R.N., G.S.T.); and the Departments of Pathology and Surgery,..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182009701"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.08.080"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.10.1229"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520420037035"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90220-1"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16146-1"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.866053"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1982.01380350069010"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.7.934"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0967-2109(95)00108-5"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000057807.28754.7F"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000125856.25309.86"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000074204.92443.37"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4201.097839"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3171\/2010.3.JNS091057"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.09090535"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000204638.91099.91"},{"key":"e_1_3_3_19_2","first-page":"287","article-title":"Association between signal hyperintensity on T1-weighted MR imaging of carotid plaques and ipsilateral ischemic events","volume":"28","author":"Yamada N","year":"2007","unstructured":"Yamada N, Higashi M, Otsubo R, Sakuma T, Oyama N, Tanaka R, Iihara K, Naritomi H, Minematsu K, Naito H. 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