{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:05:44Z","timestamp":1791993944066,"version":"4.4.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>Anderson-Fabry disease (AFD) is a rare but underdiagnosed intracellular lipid disorder that can cause left ventricular hypertrophy (LVH). Lipid is known to shorten the magnetic resonance imaging parameter T1. We hypothesized that noncontrast T1 mapping by cardiovascular magnetic resonance would provide a novel and useful measure in this disease with potential to detect early cardiac involvement and distinguish AFD LVH from other causes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>\n                      Two hundred twenty-seven subjects were studied: patients with AFD (n=44; 55% with LVH), healthy volunteers (n=67; 0% with LVH), patients with hypertension (n=41; 24% with LVH), patients with hypertrophic cardiomyopathy (n=34; 100% with LVH), those with severe aortic stenosis (n=21; 81% with LVH), and patients with definite amyloid light-chain (AL) cardiac amyloidosis (n=20; 100% with LVH). T1 mapping was performed using the shortened modified Look-Locker inversion sequence on a 1.5-T magnet before gadolinium administration with primary results derived from the basal and midseptum. Compared with health volunteers, septal T1 was lower in AFD and higher in other diseases (AFD versus healthy volunteers versus other patients, 882\u00b147, 968\u00b132, 1018\u00b174 milliseconds;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001). In patients with LVH (n=105), T1 discriminated completely between AFD and other diseases with no overlap. In AFD, T1 correlated inversely with wall thickness (\n                      <jats:italic>r<\/jats:italic>\n                      =\u22120.51;\n                      <jats:italic>P<\/jats:italic>\n                      =0.0004) and was abnormal in 40% of subjects who did not have LVH. Segmentally, AFD showed pseudonormalization or elevation of T1 in the left ventricular inferolateral wall, correlating with the presence or absence of late gadolinium enhancement (1001\u00b182 versus 891\u00b138 milliseconds;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Noncontrast T1 mapping shows potential as a unique and powerful measurement in the imaging assessment of LVH and AFD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circimaging.112.000070","type":"journal-article","created":{"date-parts":[[2013,4,6]],"date-time":"2013-04-06T01:02:51Z","timestamp":1365210171000},"page":"392-398","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":465,"title":["Identification and Assessment of Anderson-Fabry Disease by Cardiovascular Magnetic Resonance Noncontrast Myocardial T1 Mapping"],"prefix":"10.1161","volume":"6","author":[{"given":"Daniel M.","family":"Sado","sequence":"first","affiliation":[{"name":"From The Heart Hospital, London, UK (D.M.S., S.K.W., S.M.B., T.T., G.C., M.F., V.M., A.S.F., P.M.E., J.C.M.); Institute of Cardiovascular Science, University College London, London, UK (D.M.S., S.K.W., S.M.B., G.C., P.M.E., J.C.M.); Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK (S.K.P., M.D.R., S.N.); Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, University College London, London, UK ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven K.","family":"White","sequence":"additional","affiliation":[{"name":"From The Heart Hospital, London, UK (D.M.S., S.K.W., S.M.B., T.T., G.C., M.F., V.M., A.S.F., P.M.E., J.C.M.); Institute of Cardiovascular Science, University College London, London, UK (D.M.S., S.K.W., S.M.B., G.C., P.M.E., J.C.M.); Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK (S.K.P., M.D.R., S.N.); Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, University College London, London, UK ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan K.","family":"Piechnik","sequence":"additional","affiliation":[{"name":"From The Heart Hospital, London, UK (D.M.S., S.K.W., S.M.B., T.T., G.C., M.F., V.M., A.S.F., P.M.E., J.C.M.); Institute of Cardiovascular Science, University College London, London, UK (D.M.S., S.K.W., S.M.B., G.C., P.M.E., J.C.M.); Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK (S.K.P., M.D.R., S.N.); Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, University College London, London, UK ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay M.","family":"Banypersad","sequence":"additional","affiliation":[{"name":"From The Heart Hospital, London, UK (D.M.S., S.K.W., S.M.B., T.T., G.C., M.F., V.M., A.S.F., P.M.E., J.C.M.); Institute of Cardiovascular Science, University College London, London, UK (D.M.S., S.K.W., S.M.B., G.C., P.M.E., J.C.M.); Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK (S.K.P., M.D.R., S.N.); Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, University College London, London, UK ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Treibel","sequence":"additional","affiliation":[{"name":"From The Heart Hospital, London, UK (D.M.S., S.K.W., S.M.B., T.T., G.C., M.F., V.M., A.S.F., P.M.E., J.C.M.); Institute of Cardiovascular Science, University College London, London, UK (D.M.S., S.K.W., S.M.B., G.C., P.M.E., J.C.M.); Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK (S.K.P., M.D.R., S.N.); Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, University College London, London, UK ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Captur","sequence":"additional","affiliation":[{"name":"From The Heart Hospital, London, UK (D.M.S., S.K.W., S.M.B., T.T., G.C., M.F., V.M., A.S.F., P.M.E., J.C.M.); Institute of Cardiovascular Science, University College London, London, UK (D.M.S., S.K.W., S.M.B., G.C., P.M.E., J.C.M.); Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK (S.K.P., M.D.R., S.N.); Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, University College London, London, UK ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Fontana","sequence":"additional","affiliation":[{"name":"From The Heart Hospital, London, UK (D.M.S., S.K.W., S.M.B., T.T., G.C., M.F., V.M., A.S.F., P.M.E., J.C.M.); Institute of Cardiovascular Science, University College London, London, UK (D.M.S., S.K.W., S.M.B., G.C., P.M.E., J.C.M.); Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK (S.K.P., M.D.R., S.N.); Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, University College London, London, UK ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Maestrini","sequence":"additional","affiliation":[{"name":"From The Heart Hospital, London, UK (D.M.S., S.K.W., S.M.B., T.T., G.C., M.F., V.M., A.S.F., P.M.E., J.C.M.); Institute of Cardiovascular Science, University College London, London, UK (D.M.S., S.K.W., S.M.B., G.C., P.M.E., J.C.M.); Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK (S.K.P., M.D.R., S.N.); Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, University College London, London, UK ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Flett","sequence":"additional","affiliation":[{"name":"From The Heart Hospital, London, UK (D.M.S., S.K.W., S.M.B., T.T., G.C., M.F., V.M., A.S.F., P.M.E., J.C.M.); Institute of Cardiovascular Science, University College London, London, UK (D.M.S., S.K.W., S.M.B., G.C., P.M.E., J.C.M.); Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK (S.K.P., M.D.R., S.N.); Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, University College London, London, UK ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Robson","sequence":"additional","affiliation":[{"name":"From The Heart Hospital, London, UK (D.M.S., S.K.W., S.M.B., T.T., G.C., M.F., V.M., A.S.F., P.M.E., J.C.M.); Institute of Cardiovascular Science, University College London, London, UK (D.M.S., S.K.W., S.M.B., G.C., P.M.E., J.C.M.); Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK (S.K.P., M.D.R., S.N.); Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, University College London, London, UK ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin H.","family":"Lachmann","sequence":"additional","affiliation":[{"name":"From The Heart Hospital, London, UK (D.M.S., S.K.W., S.M.B., T.T., G.C., M.F., V.M., A.S.F., P.M.E., J.C.M.); Institute of Cardiovascular Science, University College London, London, UK (D.M.S., S.K.W., S.M.B., G.C., P.M.E., J.C.M.); Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK (S.K.P., M.D.R., S.N.); Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, University College London, London, UK ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Murphy","sequence":"additional","affiliation":[{"name":"From The Heart Hospital, London, UK (D.M.S., S.K.W., S.M.B., T.T., G.C., M.F., V.M., A.S.F., P.M.E., J.C.M.); Institute of Cardiovascular Science, University College London, London, UK (D.M.S., S.K.W., S.M.B., G.C., P.M.E., J.C.M.); Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK (S.K.P., M.D.R., S.N.); Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, University College London, London, UK ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Mehta","sequence":"additional","affiliation":[{"name":"From The Heart Hospital, London, UK (D.M.S., S.K.W., S.M.B., T.T., G.C., M.F., V.M., A.S.F., P.M.E., J.C.M.); Institute of Cardiovascular Science, University College London, London, UK (D.M.S., S.K.W., S.M.B., G.C., P.M.E., J.C.M.); Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK (S.K.P., M.D.R., S.N.); Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, University College London, London, UK ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derralynn","family":"Hughes","sequence":"additional","affiliation":[{"name":"From The Heart Hospital, London, UK (D.M.S., S.K.W., S.M.B., T.T., G.C., M.F., V.M., A.S.F., P.M.E., J.C.M.); Institute of Cardiovascular Science, University College London, London, UK (D.M.S., S.K.W., S.M.B., G.C., P.M.E., J.C.M.); Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK (S.K.P., M.D.R., S.N.); Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, University College London, London, UK ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Neubauer","sequence":"additional","affiliation":[{"name":"From The Heart Hospital, London, UK (D.M.S., S.K.W., S.M.B., T.T., G.C., M.F., V.M., A.S.F., P.M.E., J.C.M.); Institute of Cardiovascular Science, University College London, London, UK (D.M.S., S.K.W., S.M.B., G.C., P.M.E., J.C.M.); Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK (S.K.P., M.D.R., S.N.); Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, University College London, London, UK ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry M.","family":"Elliott","sequence":"additional","affiliation":[{"name":"From The Heart Hospital, London, UK (D.M.S., S.K.W., S.M.B., T.T., G.C., M.F., V.M., A.S.F., P.M.E., J.C.M.); Institute of Cardiovascular Science, University College London, London, UK (D.M.S., S.K.W., S.M.B., G.C., P.M.E., J.C.M.); Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK (S.K.P., M.D.R., S.N.); Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, University College London, London, UK ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Moon","sequence":"additional","affiliation":[{"name":"From The Heart Hospital, London, UK (D.M.S., S.K.W., S.M.B., T.T., G.C., M.F., V.M., A.S.F., P.M.E., J.C.M.); Institute of Cardiovascular Science, University College London, London, UK (D.M.S., S.K.W., S.M.B., G.C., P.M.E., J.C.M.); Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK (S.K.P., M.D.R., S.N.); Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, University College London, London, UK ..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.063818"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2009.11.002"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107053450102"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.104026"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2009.072462"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2000.105105"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-42"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-12-69"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.11.013"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/circimaging.112.976738"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/10976640600572889"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.gim.0000237866.70357.c6"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055484"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-88"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001683"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm342"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm095"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.190405"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2003.09.017"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-43"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0402.102975"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2009.05.003"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302346"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2011.01.020"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.05.010"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01606034"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910140306"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.3.249"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2004.01309.x"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp105"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300364"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.089409"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/circimaging.112.979815"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22753"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.104.504415"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.112.000070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T21:11:42Z","timestamp":1715548302000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.112.000070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1161\/CIRCIMAGING.112.000070"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.112.000070","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"2012-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}