{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:11:55Z","timestamp":1791483115450,"version":"4.3.4"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>There are very few validated prognostic markers in pediatric pulmonary hypertension. Cardiac MRI is a useful, noninvasive method for determining prognosis in adults. The present study is the first to assess its prognostic value in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>\n                      A total of 100 children with pulmonary hypertension (median, 10.4 years; range, 0.5\u201317.6 years) were evaluated (idiopathic, n=60; repaired congenital heart disease, n=22; miscellaneous, n=18). In all patients, ventricular volumes and great vessel flow were measured. Volumetric data were obtained using retrospectively gated cine imaging (n=37) or real-time imaging (n=63), depending on the patient\u2019s ability to hold his or her breath. During a median follow-up of 1.9 years, 11 patients died and 3 received lung transplantation. Of the cardiac MR parameters measured, right ventricular ejection fraction and left ventricular stroke volume index were most strongly predictive of survival on univariate analysis (2.6- and 2.5-fold increase in mortality for every 1-SD decrease, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.05). These results were reflected in good separation of tertile-based Kaplan-Meier survival curves for these variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Cardiac MR measures correlate with clinical status and prognosis in children with pulmonary hypertension. Cardiac MR is feasible and may be useful in clinical decision making in pediatric pulmonary hypertension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circimaging.112.000082","type":"journal-article","created":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T01:18:22Z","timestamp":1365556702000},"page":"407-414","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":112,"title":["Prognostic Significance of Cardiac Magnetic Resonance Imaging in Children With Pulmonary Hypertension"],"prefix":"10.1161","volume":"6","author":[{"given":"Shahin","family":"Moledina","sequence":"first","affiliation":[{"name":"From the Centre for Cardiovascular Imaging, UCL Institute of Cardiovascular Science, London, UK (S.M., B.P., K.H.M., A.M.T., V.M.);and National Pulmonary Hypertension Service, Great Ormond Street Hospital for Children, London, UK (S.M., M.B., M.M., S.Q., S.G.H., I.S.-N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bejal","family":"Pandya","sequence":"additional","affiliation":[{"name":"From the Centre for Cardiovascular Imaging, UCL Institute of Cardiovascular Science, London, UK (S.M., B.P., K.H.M., A.M.T., V.M.);and National Pulmonary Hypertension Service, Great Ormond Street Hospital for Children, London, UK (S.M., M.B., M.M., S.Q., S.G.H., I.S.-N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Bartsota","sequence":"additional","affiliation":[{"name":"From the Centre for Cardiovascular Imaging, UCL Institute of Cardiovascular Science, London, UK (S.M., B.P., K.H.M., A.M.T., V.M.);and National Pulmonary Hypertension Service, Great Ormond Street Hospital for Children, London, UK (S.M., M.B., M.M., S.Q., S.G.H., I.S.-N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian H.","family":"Mortensen","sequence":"additional","affiliation":[{"name":"From the Centre for Cardiovascular Imaging, UCL Institute of Cardiovascular Science, London, UK (S.M., B.P., K.H.M., A.M.T., V.M.);and National Pulmonary Hypertension Service, Great Ormond Street Hospital for Children, London, UK (S.M., M.B., M.M., S.Q., S.G.H., I.S.-N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merlin","family":"McMillan","sequence":"additional","affiliation":[{"name":"From the Centre for Cardiovascular Imaging, UCL Institute of Cardiovascular Science, London, UK (S.M., B.P., K.H.M., A.M.T., V.M.);and National Pulmonary Hypertension Service, Great Ormond Street Hospital for Children, London, UK (S.M., M.B., M.M., S.Q., S.G.H., I.S.-N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadia","family":"Quyam","sequence":"additional","affiliation":[{"name":"From the Centre for Cardiovascular Imaging, UCL Institute of Cardiovascular Science, London, UK (S.M., B.P., K.H.M., A.M.T., V.M.);and National Pulmonary Hypertension Service, Great Ormond Street Hospital for Children, London, UK (S.M., M.B., M.M., S.Q., S.G.H., I.S.-N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Taylor","sequence":"additional","affiliation":[{"name":"From the Centre for Cardiovascular Imaging, UCL Institute of Cardiovascular Science, London, UK (S.M., B.P., K.H.M., A.M.T., V.M.);and National Pulmonary Hypertension Service, Great Ormond Street Hospital for Children, London, UK (S.M., M.B., M.M., S.Q., S.G.H., I.S.-N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila G.","family":"Haworth","sequence":"additional","affiliation":[{"name":"From the Centre for Cardiovascular Imaging, UCL Institute of Cardiovascular Science, London, UK (S.M., B.P., K.H.M., A.M.T., V.M.);and National Pulmonary Hypertension Service, Great Ormond Street Hospital for Children, London, UK (S.M., M.B., M.M., S.Q., S.G.H., I.S.-N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingram","family":"Schulze-Neick","sequence":"additional","affiliation":[{"name":"From the Centre for Cardiovascular Imaging, UCL Institute of Cardiovascular Science, London, UK (S.M., B.P., K.H.M., A.M.T., V.M.);and National Pulmonary Hypertension Service, Great Ormond Street Hospital for Children, London, UK (S.M., M.B., M.M., S.Q., S.G.H., I.S.-N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Muthurangu","sequence":"additional","affiliation":[{"name":"From the Centre for Cardiovascular Imaging, UCL Institute of Cardiovascular Science, London, UK (S.M., B.P., K.H.M., A.M.T., V.M.);and National Pulmonary Hypertension Service, Great Ormond Street Hospital for Children, London, UK (S.M., M.B., M.M., S.Q., S.G.H., 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