{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:07:00Z","timestamp":1791288420532,"version":"4.3.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>\n              The relationship between biomechanical properties and biological activities in aortic aneurysms was investigated with finite element simulations and\n              <jats:sup>18<\/jats:sup>\n              F-fluoro-deoxy-glucose (\n              <jats:sup>18<\/jats:sup>\n              F-FDG) positron emission tomography.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              The study included 53 patients (45 men) with aortic aneurysms, 47 infrarenal (abdominal aortic) and 6 thoracic (thoracic aortic), who had \u22651\n              <jats:sup>18<\/jats:sup>\n              F-FDG positron emission tomography\/computed tomography. During a 30-month period, more clinical events occurred in patients with increased\n              <jats:sup>18<\/jats:sup>\n              F-FDG uptake on their last examination than in those without (5 of 18 [28%] versus 2 of 35 [6%];\n              <jats:italic>P<\/jats:italic>\n              =0.03). Wall stress and stress\/strength index computed by finite element simulations and\n              <jats:sup>18<\/jats:sup>\n              F-FDG uptake were evaluated in a total of 68 examinations. Twenty-five (38%) examinations demonstrated \u22651 aneurysm wall area of increased\n              <jats:sup>18<\/jats:sup>\n              F-FDG uptake. The mean number of these areas per examination was 1.6 (18 of 11) in thoracic aortic aneurysms versus 0.25 (14 of 57) in abdominal aortic aneurysms, whereas the mean number of increased uptake areas colocalizing with highest wall stress and stress\/strength index areas was 0.55 (6 of 11) and 0.02 (1 of 57), respectively. Quantitatively,\n              <jats:sup>18<\/jats:sup>\n              F-FDG positron emission tomographic uptake correlated positively with both wall stress and stress\/strength index (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05).\n              <jats:sup>18<\/jats:sup>\n              F-FDG uptake was particularly high in subjects with personal history of angina pectoris and familial aneurysm.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              Increased\n              <jats:sup>18<\/jats:sup>\n              F-FDG positron emission tomographic uptake in aortic aneurysms is strongly related to aneurysm location, wall stress as derived by finite element simulations, and patient risk factors such as acquired and inherited susceptibilities.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.112.000415","type":"journal-article","created":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T03:55:05Z","timestamp":1383623705000},"page":"82-91","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":59,"title":["Multifactorial Relationship Between\n            <sup>18<\/sup>\n            F-Fluoro-Deoxy-Glucose Positron Emission Tomography Signaling and Biomechanical Properties in Unruptured Aortic Aneurysms"],"prefix":"10.1161","volume":"7","author":[{"given":"Alain","family":"Nchimi","sequence":"first","affiliation":[{"name":"From the Departments of Cardiovascular and Thoracic Imaging (A.N.) and Cardiovascular and Thoracic Surgery (J.-P.C.-B., J.O.D., N.S.), University Hospital, Li\u00e8ge, Belgium; Department of Solid Mechanics, Royal Institute of Technology (KTH), Stockholm, Sweden (T.C.G.); Department of Nuclear Medicine, Centre Hospitalier Chr\u00e9tien St Joseph, Li\u00e8ge, Belgium (G.N., P.G.); Medical Informatics and Biostatistics, University of Li\u00e8ge, Li\u00e8ge, Belgium (L.S., A.A.); and Stony Brook University Medical Center, NY ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Cheramy-Bien","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiovascular and Thoracic Imaging (A.N.) and Cardiovascular and Thoracic Surgery (J.-P.C.-B., J.O.D., N.S.), University Hospital, Li\u00e8ge, Belgium; Department of Solid Mechanics, Royal Institute of Technology (KTH), Stockholm, Sweden (T.C.G.); Department of Nuclear Medicine, Centre Hospitalier Chr\u00e9tien St Joseph, Li\u00e8ge, Belgium (G.N., P.G.); Medical Informatics and Biostatistics, University of Li\u00e8ge, Li\u00e8ge, Belgium (L.S., A.A.); and Stony Brook University Medical Center, NY ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Christian","family":"Gasser","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiovascular and Thoracic Imaging (A.N.) and Cardiovascular and Thoracic Surgery (J.-P.C.-B., J.O.D., N.S.), University Hospital, Li\u00e8ge, Belgium; Department of Solid Mechanics, Royal Institute of Technology (KTH), Stockholm, Sweden (T.C.G.); Department of Nuclear Medicine, Centre Hospitalier Chr\u00e9tien St Joseph, Li\u00e8ge, Belgium (G.N., P.G.); Medical Informatics and Biostatistics, University of Li\u00e8ge, Li\u00e8ge, Belgium (L.S., A.A.); and Stony Brook University Medical Center, NY ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauthier","family":"Namur","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiovascular and Thoracic Imaging (A.N.) and Cardiovascular and Thoracic Surgery (J.-P.C.-B., J.O.D., N.S.), University Hospital, Li\u00e8ge, Belgium; Department of Solid Mechanics, Royal Institute of Technology (KTH), Stockholm, Sweden (T.C.G.); Department of Nuclear Medicine, Centre Hospitalier Chr\u00e9tien St Joseph, Li\u00e8ge, Belgium (G.N., P.G.); Medical Informatics and Biostatistics, University of Li\u00e8ge, Li\u00e8ge, Belgium (L.S., A.A.); and Stony Brook University Medical Center, NY ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Gomez","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiovascular and Thoracic Imaging (A.N.) and Cardiovascular and Thoracic Surgery (J.-P.C.-B., J.O.D., N.S.), University Hospital, Li\u00e8ge, Belgium; Department of Solid Mechanics, Royal Institute of Technology (KTH), Stockholm, Sweden (T.C.G.); Department of Nuclear Medicine, Centre Hospitalier Chr\u00e9tien St Joseph, Li\u00e8ge, Belgium (G.N., P.G.); Medical Informatics and Biostatistics, University of Li\u00e8ge, Li\u00e8ge, Belgium (L.S., A.A.); and Stony Brook University Medical Center, NY ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Seidel","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiovascular and Thoracic Imaging (A.N.) and Cardiovascular and Thoracic Surgery (J.-P.C.-B., J.O.D., N.S.), University Hospital, Li\u00e8ge, Belgium; Department of Solid Mechanics, Royal Institute of Technology (KTH), Stockholm, Sweden (T.C.G.); Department of Nuclear Medicine, Centre Hospitalier Chr\u00e9tien St Joseph, Li\u00e8ge, Belgium (G.N., P.G.); Medical Informatics and Biostatistics, University of Li\u00e8ge, Li\u00e8ge, Belgium (L.S., A.A.); and Stony Brook University Medical Center, NY ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelin","family":"Albert","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiovascular and Thoracic Imaging (A.N.) and Cardiovascular and Thoracic Surgery (J.-P.C.-B., J.O.D., N.S.), University Hospital, Li\u00e8ge, Belgium; Department of Solid Mechanics, Royal Institute of Technology (KTH), Stockholm, Sweden (T.C.G.); Department of Nuclear Medicine, Centre Hospitalier Chr\u00e9tien St Joseph, Li\u00e8ge, Belgium (G.N., P.G.); Medical Informatics and Biostatistics, University of Li\u00e8ge, Li\u00e8ge, Belgium (L.S., A.A.); and Stony Brook University Medical Center, NY ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Olivier","family":"Defraigne","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiovascular and Thoracic Imaging (A.N.) and Cardiovascular and Thoracic Surgery (J.-P.C.-B., J.O.D., N.S.), University Hospital, Li\u00e8ge, Belgium; Department of Solid Mechanics, Royal Institute of Technology (KTH), Stockholm, Sweden (T.C.G.); Department of Nuclear Medicine, Centre Hospitalier Chr\u00e9tien St Joseph, Li\u00e8ge, Belgium (G.N., P.G.); Medical Informatics and Biostatistics, University of Li\u00e8ge, Li\u00e8ge, Belgium (L.S., A.A.); and Stony Brook University Medical Center, NY ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicos","family":"Labropoulos","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiovascular and Thoracic Imaging (A.N.) and Cardiovascular and Thoracic Surgery (J.-P.C.-B., J.O.D., N.S.), University Hospital, Li\u00e8ge, Belgium; Department of Solid Mechanics, Royal Institute of Technology (KTH), Stockholm, Sweden (T.C.G.); Department of Nuclear Medicine, Centre Hospitalier Chr\u00e9tien St Joseph, Li\u00e8ge, Belgium (G.N., P.G.); Medical Informatics and Biostatistics, University of Li\u00e8ge, Li\u00e8ge, Belgium (L.S., A.A.); and Stony Brook University Medical Center, NY ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natzi","family":"Sakalihasan","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiovascular and Thoracic Imaging (A.N.) and Cardiovascular and Thoracic Surgery (J.-P.C.-B., J.O.D., N.S.), University Hospital, Li\u00e8ge, Belgium; Department of Solid Mechanics, Royal Institute of Technology (KTH), Stockholm, Sweden (T.C.G.); Department of Nuclear Medicine, Centre Hospitalier Chr\u00e9tien St Joseph, Li\u00e8ge, Belgium (G.N., P.G.); Medical Informatics and Biostatistics, University of Li\u00e8ge, Li\u00e8ge, Belgium (L.S., A.A.); and Stony Brook University Medical Center, NY ..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(95)00045-3"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb33294.x"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.11.017"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909305"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000133279.07468.9F"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)04147-4"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2003.363"},{"key":"e_1_3_4_9_2","first-page":"II161","article-title":"Autopsy study of unoperated abdominal aortic aneurysms. The case for early resection.","volume":"56","author":"Darling RC","year":"1977","unstructured":"Darling RC, Messina CR, Brewster DC, Ottinger LW. Autopsy study of unoperated abdominal aortic aneurysms. The case for early resection. Circulation. 1977;56(3 Suppl):II161\u2013II164.","journal-title":"Circulation"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(98)70065-5"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199909000-00002"},{"key":"e_1_3_4_12_2","volume-title":"The Finite Elements Method. The Basis","author":"Zienkiewicz OC","year":"2000","unstructured":"Zienkiewicz OC, Taylor R.L., J.Z. Zhu. The Finite Elements Method. The Basis. 5th ed. Oxford, United Kingdom: Butterworth-Heinemann;2000.","edition":"5"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2011.06.004"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.01.036"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.106.137851"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64447-1"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2148"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(03)00513-3"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2008.12.024"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1583\/08-2447.1"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2008.12.016"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2004.03.002"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.rlu.0000159681.24833.95"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.03.059"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2009.10.016"},{"key":"e_1_3_4_26_2","unstructured":"http:\/\/ec.europa.eu\/research\/health\/medical-research\/cardiovascular-diseases\/projects\/fad_en.html. Accessed November 25 2013."},{"key":"e_1_3_4_27_2","unstructured":"A4clinics User Manual vers. 3.0 VG. A4clinics Vascops GmbH Graz Austria."},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.109.858712"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-010-0191-0"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2002.126087"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(03)00791-2"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)44876-0"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2003.213"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66459-8"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.180"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(95)70196-6"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2009.11.021"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2010.04.003"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.09.008"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.112.000415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:13:26Z","timestamp":1715562806000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.112.000415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1161\/CIRCIMAGING.112.000415"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.112.000415","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"2012-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}