{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T23:45:53Z","timestamp":1771890353518,"version":"3.50.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Noninvasive echocardiographic differentiation between old and fresh left ventricular thrombi after myocardial infarction would be of clinical importance to estimate the risk for embolization and the necessity of anticoagulation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Fifty-two patients, aged 41 to 87 years, with a thrombus after myocardial infarction were included in this 2-part study: In substudy-I, 20 patients, 10 each with a definite diagnosis of fresh or old thrombus, were included. In the subsequent prospective substudy-II, 32 consecutive patients with an incident thrombus after myocardial infarction but unknown thrombus age were started on phenprocoumon and followed for 6 months. Data on medical history, standard echocardiography, strain-rate (SR) imaging and magnetic resonance tomography were analyzed. In substudy-I, analysis of thrombus deformation revealed the most rapid change in SR during the isovolumetric relaxation period when cavity pressure decreases rapidly. Fresh (range: 5\u201327 days) and old thrombi (4\u201326 months) could be discriminated without overlap by peak SR during the isovolumetric relaxation period, using a cutoff value of 1 s\n              <jats:sup>\u22121<\/jats:sup>\n              . Applying this threshold value in substudy-II, 17 thrombi were echocardiographically classified as fresh (=SR \u22651 s\n              <jats:sup>\u22121<\/jats:sup>\n              ) and 15 as old. After 6 months in the fresh thrombus group, 16 of 17 thrombi had disappeared (94%), and in 1 patient the thrombus size was diminished by &gt;50% (now presenting an old thrombus SR pattern). In contrast, 14 of the 15 old thrombi remained unchanged in size and deformation (1 thrombus disappeared).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Fresh and old intracavitary thrombi can be reliably differentiated by deformation imaging. In fresh thrombi, anticoagulation with phenprocoumon results in thrombus resolution in most patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.112.974964","type":"journal-article","created":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T06:34:10Z","timestamp":1341556450000},"page":"667-675","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Differentiation Between Fresh and Old Left Ventricular Thrombi by Deformation Imaging"],"prefix":"10.1161","volume":"5","author":[{"given":"Markus","family":"Niemann","sequence":"first","affiliation":[{"name":"From the Comprehensive Heart Failure Center (M.N., P.D.G., S.S., M.B., S.H., K.H., G.E., F.W.), Department of Internal Medicine I (M.N., P.D.G., S.S., H.H., S.H., K.H., G.E., F.W.), and Institute of Radiology (M.B.), University of Wuerzburg, Germany; ICREA-Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and University of Zagreb School of Medicine, Department of Cardiovascular Diseases, University Hospital Center Zagreb, Croatia (M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp Daniel","family":"Gaudron","sequence":"additional","affiliation":[{"name":"From the Comprehensive Heart Failure Center (M.N., P.D.G., S.S., M.B., S.H., K.H., G.E., F.W.), Department of Internal Medicine I (M.N., P.D.G., S.S., H.H., S.H., K.H., G.E., F.W.), and Institute of Radiology (M.B.), University of Wuerzburg, Germany; ICREA-Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and University of Zagreb School of Medicine, Department of Cardiovascular Diseases, University Hospital Center Zagreb, Croatia (M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart","family":"Bijnens","sequence":"additional","affiliation":[{"name":"From the Comprehensive Heart Failure Center (M.N., P.D.G., S.S., M.B., S.H., K.H., G.E., F.W.), Department of Internal Medicine I (M.N., P.D.G., S.S., H.H., S.H., K.H., G.E., F.W.), and Institute of Radiology (M.B.), University of Wuerzburg, Germany; ICREA-Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and University of Zagreb School of Medicine, Department of Cardiovascular Diseases, University Hospital Center Zagreb, Croatia (M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"St\u00f6rk","sequence":"additional","affiliation":[{"name":"From the Comprehensive Heart Failure Center (M.N., P.D.G., S.S., M.B., S.H., K.H., G.E., F.W.), Department of Internal Medicine I (M.N., P.D.G., S.S., H.H., S.H., K.H., G.E., F.W.), and Institute of Radiology (M.B.), University of Wuerzburg, Germany; ICREA-Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and University of Zagreb School of Medicine, Department of Cardiovascular Diseases, University Hospital Center Zagreb, Croatia (M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meinrad","family":"Beer","sequence":"additional","affiliation":[{"name":"From the Comprehensive Heart Failure Center (M.N., P.D.G., S.S., M.B., S.H., K.H., G.E., F.W.), Department of Internal Medicine I (M.N., P.D.G., S.S., H.H., S.H., K.H., G.E., F.W.), and Institute of Radiology (M.B.), University of Wuerzburg, Germany; ICREA-Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and University of Zagreb School of Medicine, Department of Cardiovascular Diseases, University Hospital Center Zagreb, Croatia (M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanns","family":"Hillenbrand","sequence":"additional","affiliation":[{"name":"From the Comprehensive Heart Failure Center (M.N., P.D.G., S.S., M.B., S.H., K.H., G.E., F.W.), Department of Internal Medicine I (M.N., P.D.G., S.S., H.H., S.H., K.H., G.E., F.W.), and Institute of Radiology (M.B.), University of Wuerzburg, Germany; ICREA-Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and University of Zagreb School of Medicine, Department of Cardiovascular Diseases, University Hospital Center Zagreb, Croatia (M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Cikes","sequence":"additional","affiliation":[{"name":"From the Comprehensive Heart Failure Center (M.N., P.D.G., S.S., M.B., S.H., K.H., G.E., F.W.), Department of Internal Medicine I (M.N., P.D.G., S.S., H.H., S.H., K.H., G.E., F.W.), and Institute of Radiology (M.B.), University of Wuerzburg, Germany; ICREA-Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and University of Zagreb School of Medicine, Department of Cardiovascular Diseases, University Hospital Center Zagreb, Croatia (M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Herrmann","sequence":"additional","affiliation":[{"name":"From the Comprehensive Heart Failure Center (M.N., P.D.G., S.S., M.B., S.H., K.H., G.E., F.W.), Department of Internal Medicine I (M.N., P.D.G., S.S., H.H., S.H., K.H., G.E., F.W.), and Institute of Radiology (M.B.), University of Wuerzburg, Germany; ICREA-Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and University of Zagreb School of Medicine, Department of Cardiovascular Diseases, University Hospital Center Zagreb, Croatia (M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Hu","sequence":"additional","affiliation":[{"name":"From the Comprehensive Heart Failure Center (M.N., P.D.G., S.S., M.B., S.H., K.H., G.E., F.W.), Department of Internal Medicine I (M.N., P.D.G., S.S., H.H., S.H., K.H., G.E., F.W.), and Institute of Radiology (M.B.), University of Wuerzburg, Germany; ICREA-Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and University of Zagreb School of Medicine, Department of Cardiovascular Diseases, University Hospital Center Zagreb, Croatia (M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Ertl","sequence":"additional","affiliation":[{"name":"From the Comprehensive Heart Failure Center (M.N., P.D.G., S.S., M.B., S.H., K.H., G.E., F.W.), Department of Internal Medicine I (M.N., P.D.G., S.S., H.H., S.H., K.H., G.E., F.W.), and Institute of Radiology (M.B.), University of Wuerzburg, Germany; ICREA-Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and University of Zagreb School of Medicine, Department of Cardiovascular Diseases, University Hospital Center Zagreb, Croatia (M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Weidemann","sequence":"additional","affiliation":[{"name":"From the Comprehensive Heart Failure Center (M.N., P.D.G., S.S., M.B., S.H., K.H., G.E., F.W.), Department of Internal Medicine I (M.N., P.D.G., S.S., H.H., S.H., K.H., G.E., F.W.), and Institute of Radiology (M.B.), University of Wuerzburg, Germany; ICREA-Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and University of Zagreb School of Medicine, Department of Cardiovascular Diseases, University Hospital Center Zagreb, Croatia (M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000134791.68010.FA"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)91069-D"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90341-0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.75.5.1004"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80336-3"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198108063050601"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.2.512"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00392-5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1998.0871"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00003-4"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90409-T"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-6-789"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.08.021"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000044389.51236.91"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.179.6.1791539"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.113.10.e409"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jen323"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.10.040"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.01.032"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.11.023"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm454"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00429.2011"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0967-2109(96)00008-7"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90873-4"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.001"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90275-T"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.72.4.774"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90798-2"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012369367-9\/50778-3"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-104-5-689"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000199147.30016.74"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90463-4"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.112.974964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:29:48Z","timestamp":1715563788000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.112.974964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1161\/CIRCIMAGING.112.974964"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.112.974964","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"2012-01-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-06-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-07-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}