{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:00:30Z","timestamp":1792569630853,"version":"4.5.0"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>\n              Fabry disease (FD) is an X-linked disorder of lysosomal metabolism affecting multiple organs with cardiac disease being the leading cause of death. Current imaging evaluations of the heart are suboptimal. The goals of the current study are to evaluate the potential of quantitative T\n              <jats:sub>1<\/jats:sub>\n              mapping with cardiovascular MRI as a disease-specific imaging biomarker.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              A total of 31 patients with FD, 23 healthy controls, and 21 subjects with concentric remodeling or hypertrophy underwent cardiovascular MRI to measure left ventricular (LV) morphology, function, delayed enhancement, as well as myocardial T\n              <jats:sub>1<\/jats:sub>\n              values, and derived parameters (extracellular volume). All subjects had LV ejection fraction &gt;50% and similar volumes. FD and concentric remodeling or hypertrophy had similarly increased mass, wall thickness, and mass\/volume as compared with controls. A total of 16 of 31 FD subjects and 10 of 21 concentric remodeling or hypertrophy subjects had LV hypertrophy. Noncontrast myocardial T\n              <jats:sub>1<\/jats:sub>\n              values were substantially lower in FD as compared with controls and concentric remodeling or hypertrophy (1070\u00b150, 1177\u00b127, and 1207\u00b133 ms, respectively;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), but extracellular volume was similar in all groups (21.7\u00b12.4%, 22.2\u00b13.1%, and 21.8\u00b13.9%, respectively). Single-voxel NMR spectroscopy in 4 FD and 4 healthy control subjects showed a significant negative linear relationship between lipid content and noncontrast T\n              <jats:sub>1<\/jats:sub>\n              values (\n              <jats:italic>r<\/jats:italic>\n              =\u22120.9;\n              <jats:italic>P<\/jats:italic>\n              =0.002). Female subjects had lower LV mass and wall thickness, longer myocardial T\n              <jats:sub>1<\/jats:sub>\n              values and larger extracellular volume suggesting a key sex difference in cardiac remodeling.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              Reduced noncontrast myocardial T\n              <jats:sub>1<\/jats:sub>\n              values are the most sensitive and specific cardiovascular MRI parameter in patients with FD irrespective of sex and LV morphology and function.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.113.000482","type":"journal-article","created":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T05:24:02Z","timestamp":1375853042000},"page":"637-645","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":184,"title":["T\n            <sub>1<\/sub>\n            Mapping With Cardiovascular MRI Is Highly Sensitive for Fabry Disease Independent of Hypertrophy and Sex"],"prefix":"10.1161","volume":"6","author":[{"given":"Richard B.","family":"Thompson","sequence":"first","affiliation":[{"name":"From the Departments of Biomedical Engineering (R.B.T., K.C.), Medical Genetics (A.C.), and Division of Cardiology, Mazankowski Alberta Heart Institute (M.S., I.P., G.Y.O.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; and Department of Medical Genetics and Pediatrics, University of Calgary, Calgary, Alberta, Canada (A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin","family":"Chow","sequence":"additional","affiliation":[{"name":"From the Departments of Biomedical Engineering (R.B.T., K.C.), Medical Genetics (A.C.), and Division of Cardiology, Mazankowski Alberta Heart Institute (M.S., I.P., G.Y.O.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; and Department of Medical Genetics and Pediatrics, University of Calgary, Calgary, Alberta, Canada (A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneal","family":"Khan","sequence":"additional","affiliation":[{"name":"From the Departments of Biomedical Engineering (R.B.T., K.C.), Medical Genetics (A.C.), and Division of Cardiology, Mazankowski Alberta Heart Institute (M.S., I.P., G.Y.O.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; and Department of Medical Genetics and Pediatrics, University of Calgary, Calgary, Alberta, Canada (A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Chan","sequence":"additional","affiliation":[{"name":"From the Departments of Biomedical Engineering (R.B.T., K.C.), Medical Genetics (A.C.), and Division of Cardiology, Mazankowski Alberta Heart Institute (M.S., I.P., G.Y.O.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; and Department of Medical Genetics and Pediatrics, University of Calgary, Calgary, Alberta, Canada (A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Shanks","sequence":"additional","affiliation":[{"name":"From the Departments of Biomedical Engineering (R.B.T., K.C.), Medical Genetics (A.C.), and Division of Cardiology, Mazankowski Alberta Heart Institute (M.S., I.P., G.Y.O.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; and Department of Medical Genetics and Pediatrics, University of Calgary, Calgary, Alberta, Canada (A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Paterson","sequence":"additional","affiliation":[{"name":"From the Departments of Biomedical Engineering (R.B.T., K.C.), Medical Genetics (A.C.), and Division of Cardiology, Mazankowski Alberta Heart Institute (M.S., I.P., G.Y.O.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; and Department of Medical Genetics and Pediatrics, University of Calgary, Calgary, Alberta, Canada (A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin Y.","family":"Oudit","sequence":"additional","affiliation":[{"name":"From the Departments of Biomedical Engineering (R.B.T., K.C.), Medical Genetics (A.C.), and Division of Cardiology, Mazankowski Alberta Heart Institute (M.S., I.P., G.Y.O.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; 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