{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T08:31:01Z","timestamp":1789115461502,"version":"build-2803163510"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>In aortic valve stenosis (AS), the occurrence of heart failure symptoms does not always correlate with severity of valve stenosis and left ventricular (LV) function. Therefore, we tested the hypothesis that symptomatic patients with AS have impaired diastolic, longitudinal systolic function, and left atrial dilatation compared with asymptomatic patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              In a retrospective descriptive study, we compared clinical characteristics and echocardiographic parameters in 99 symptomatic and 139 asymptomatic patients with severe AS and LV ejection fraction \u226550%. Independent predictors of symptomatic state were identified using logistic regression analysis. Symptomatic patients were younger (72\u00b110 versus 76\u00b112 years of age;\n              <jats:italic>P<\/jats:italic>\n              =0.002), presented less often with atrial fibrillation (13% versus 24%;\n              <jats:italic>P<\/jats:italic>\n              =0.05) and chronic obstructive pulmonary disease (2% versus 19%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and had a lower prevalence of hypertension (73% versus 40%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Despite similar AS severity, symptomatic patients had higher LV mass index (120\u00b139 versus 95\u00b125 g\/m\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001), increased relative wall thickness (0.61\u00b10.15 versus 0.50\u00b10.11;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001), shorter mitral deceleration time (199\u00b158 versus 268\u00b162 ms;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001), and increased left atrial volume index (49\u00b118 versus 42\u00b115 mL\/m\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              =0.02). When adjusting for age, history of hypertension, atrial fibrillation, and chronic obstructive pulmonary disease in a multivariable logistic regression analysis, LV mass index, relative wall thickness, left atrial volume index, and deceleration time were still associated with the presence of symptoms.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>The present study demonstrates that symptomatic status in severe AS is associated with impaired diastolic function, LV hypertrophy, concentric remodeling, and left atrial dilatation when corrected for indices of AS severity.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00294775.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.113.000636","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T03:46:25Z","timestamp":1383191185000},"page":"142-148","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":66,"title":["Left Ventricular Diastolic Function Is Associated With Symptom Status in Severe Aortic Valve Stenosis"],"prefix":"10.1161","volume":"7","author":[{"given":"Jordi S.","family":"Dahl","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, Odense University Hospital, Odense, Denmark (J.S.D., N.L.C., L.V., M.K.P., R.C.-S., T.M.H., J.E.M.); Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (P.A.P.); and Department of Cardiology, Vejle Hospital, Vejle, Denmark (F.H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaj L.","family":"Christensen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Odense University Hospital, Odense, Denmark (J.S.D., N.L.C., L.V., M.K.P., R.C.-S., T.M.H., J.E.M.); Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (P.A.P.); and Department of Cardiology, Vejle Hospital, Vejle, Denmark (F.H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Videb\u00e6k","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Odense University Hospital, Odense, Denmark (J.S.D., N.L.C., L.V., M.K.P., R.C.-S., T.M.H., J.E.M.); Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (P.A.P.); and Department of Cardiology, Vejle Hospital, Vejle, Denmark (F.H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael K.","family":"Poulsen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Odense University Hospital, Odense, Denmark (J.S.D., N.L.C., L.V., M.K.P., R.C.-S., T.M.H., J.E.M.); Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (P.A.P.); and Department of Cardiology, Vejle Hospital, Vejle, Denmark (F.H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus","family":"Carter-Storch","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Odense University Hospital, Odense, Denmark (J.S.D., N.L.C., L.V., M.K.P., R.C.-S., T.M.H., J.E.M.); Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (P.A.P.); and Department of Cardiology, Vejle Hospital, Vejle, Denmark (F.H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Hey","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Odense University Hospital, Odense, Denmark (J.S.D., N.L.C., L.V., M.K.P., R.C.-S., T.M.H., J.E.M.); Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (P.A.P.); and Department of Cardiology, Vejle Hospital, Vejle, Denmark (F.H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Pellikka","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Odense University Hospital, Odense, Denmark (J.S.D., N.L.C., L.V., M.K.P., R.C.-S., T.M.H., J.E.M.); Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (P.A.P.); and Department of Cardiology, Vejle Hospital, Vejle, Denmark (F.H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flemming H.","family":"Steffensen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Odense University Hospital, Odense, Denmark (J.S.D., N.L.C., L.V., M.K.P., R.C.-S., T.M.H., J.E.M.); Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (P.A.P.); and Department of Cardiology, Vejle Hospital, Vejle, Denmark (F.H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob E.","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Odense University Hospital, Odense, Denmark (J.S.D., N.L.C., L.V., M.K.P., R.C.-S., T.M.H., J.E.M.); Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (P.A.P.); and Department of Cardiology, Vejle Hospital, Vejle, Denmark (F.H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm095"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.495903"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.10.013"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi290"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.01.032"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.11.029"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(03)00335-3"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.11.023"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.86.3.309"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90595-R"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.77.3.613"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.09.043"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.112.977348"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2006.11.020"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052256"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.145441"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.01.007"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr084"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.072"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.112.973834"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jes115"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.030601"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.11.048"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.113.000636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:19:41Z","timestamp":1715566781000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.113.000636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1161\/CIRCIMAGING.113.000636"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.113.000636","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"2013-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}