{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T14:19:04Z","timestamp":1782569944145,"version":"3.54.5"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Differentiation of cardiac amyloidosis (CA) from other causes of concentric left ventricular hypertrophy remains a clinical challenge, especially in patients with preserved ejection fraction at the early disease stages.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Consecutive hypertrophic patients with CA, isolated arterial hypertension, Fabry disease, and Friedreich ataxia (n=25 per group) were investigated; 25 healthy volunteers served as a control group. Standard echocardiography was performed, and segmental longitudinal peak systolic strain (LSsys) in the septum was assessed by 2-dimensional speckle tracking imaging. Indices of left ventricular hypertrophy and ejection fraction were similar among all patient groups. Deceleration time of early filling was significantly lower in patients with CA (147\u00b146 milliseconds) compared with those with isolated arterial hypertension, Fabry disease, or control subjects (all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0125). Septal basal LSsys (\u22126\u00b12%) was significantly lower in patients with CA compared with those with isolated arterial hypertension (\u221214\u00b16%), Fabry disease (\u221212\u00b15%), Friedreich ataxia (\u221216\u00b12%), or control subjects (\u221217\u00b13%; all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), whereas septal apical LSsys was similar among all patient groups and control subjects (all\n              <jats:italic>P<\/jats:italic>\n              &gt;0.05). A data-driven cutoff value for the ratio of septal apical to basal LSsys ratio &gt;2.1 differentiated CA from other causes of left ventricular hypertrophy (sensitivity, 88%; specificity, 85%; positive predictive value, 67%; negative predictive value, 96%). The prevalence of septal apical to basal LSsys ratio &gt;2.1 plus deceleration time of early filling &lt;200 milliseconds was 88% in CA but 0% in all other groups.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>A systolic septal longitudinal base-to-apex strain gradient (septal apical to basal LSsys ratio &gt;2.1), combined with a shortened diastolic deceleration time of early filling (deceleration time of early filling &lt;200 milliseconds), aids in differentiating CA from other causes of concentric left ventricular hypertrophy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.113.000683","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T02:54:46Z","timestamp":1381200886000},"page":"1066-1072","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":180,"title":["Effect of Combined Systolic and Diastolic Functional Parameter Assessment for Differentiation of Cardiac Amyloidosis From Other Causes of Concentric Left Ventricular Hypertrophy"],"prefix":"10.1161","volume":"6","author":[{"given":"Dan","family":"Liu","sequence":"first","affiliation":[{"name":"From the Department of Internal Medicine I (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), Comprehensive Heart Failure Center (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), and Department of Internal Medicine II (S.K.), University of W\u00fcrzburg, W\u00fcrzburg, Germany; Department of Cardiovascular Diseases, University Hospital Center Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia (M.C.); ICREA\u2013Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and Department of Cardiovascular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Hu","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine I (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), Comprehensive Heart Failure Center (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), and Department of Internal Medicine II (S.K.), University of W\u00fcrzburg, W\u00fcrzburg, Germany; Department of Cardiovascular Diseases, University Hospital Center Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia (M.C.); ICREA\u2013Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and Department of Cardiovascular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Niemann","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine I (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), Comprehensive Heart Failure Center (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), and Department of Internal Medicine II (S.K.), University of W\u00fcrzburg, W\u00fcrzburg, Germany; Department of Cardiovascular Diseases, University Hospital Center Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia (M.C.); ICREA\u2013Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and Department of Cardiovascular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Herrmann","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine I (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), Comprehensive Heart Failure Center (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), and Department of Internal Medicine II (S.K.), University of W\u00fcrzburg, W\u00fcrzburg, Germany; Department of Cardiovascular Diseases, University Hospital Center Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia (M.C.); ICREA\u2013Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and Department of Cardiovascular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Cikes","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine I (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), Comprehensive Heart Failure Center (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), and Department of Internal Medicine II (S.K.), University of W\u00fcrzburg, W\u00fcrzburg, Germany; Department of Cardiovascular Diseases, University Hospital Center Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia (M.C.); ICREA\u2013Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and Department of Cardiovascular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"St\u00f6rk","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine I (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), Comprehensive Heart Failure Center (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), and Department of Internal Medicine II (S.K.), University of W\u00fcrzburg, W\u00fcrzburg, Germany; Department of Cardiovascular Diseases, University Hospital Center Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia (M.C.); ICREA\u2013Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and Department of Cardiovascular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp Daniel","family":"Gaudron","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine I (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), Comprehensive Heart Failure Center (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), and Department of Internal Medicine II (S.K.), University of W\u00fcrzburg, W\u00fcrzburg, Germany; Department of Cardiovascular Diseases, University Hospital Center Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia (M.C.); ICREA\u2013Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and Department of Cardiovascular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Knop","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine I (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), Comprehensive Heart Failure Center (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), and Department of Internal Medicine II (S.K.), University of W\u00fcrzburg, W\u00fcrzburg, Germany; Department of Cardiovascular Diseases, University Hospital Center Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia (M.C.); ICREA\u2013Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and Department of Cardiovascular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Ertl","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine I (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), Comprehensive Heart Failure Center (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), and Department of Internal Medicine II (S.K.), University of W\u00fcrzburg, W\u00fcrzburg, Germany; Department of Cardiovascular Diseases, University Hospital Center Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia (M.C.); ICREA\u2013Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and Department of Cardiovascular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Bijnens","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine I (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), Comprehensive Heart Failure Center (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), and Department of Internal Medicine II (S.K.), University of W\u00fcrzburg, W\u00fcrzburg, Germany; Department of Cardiovascular Diseases, University Hospital Center Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia (M.C.); ICREA\u2013Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and Department of Cardiovascular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Weidemann","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine I (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), Comprehensive Heart Failure Center (D.L., K.H., M.N., S.H., S.S., P.D.G., G.E., F.W.), and Department of Internal Medicine II (S.K.), University of W\u00fcrzburg, W\u00fcrzburg, Germany; Department of Cardiovascular Diseases, University Hospital Center Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia (M.C.); ICREA\u2013Universitat Pompeu Fabra, Barcelona, Spain (B.B.); and Department of Cardiovascular..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.104.489187"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060225"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.08.043"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2007.01.012"},{"key":"e_1_3_3_6_2","first-page":"45","article-title":"Primary systemic amyloidosis: clinical and laboratory features in 474 cases.","volume":"32","author":"Kyle RA","year":"1995","unstructured":"Kyle RA, Gertz MA. 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