{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:41:10Z","timestamp":1781246470520,"version":"3.54.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Right ventricular diastolic dysfunction influences outcomes in pulmonary arterial hypertension (PAH), but echocardiographic parameters have not been investigated in relation to invasive reference standards in pediatric PAH. We investigated echocardiographic parameters of right ventricular diastolic function in children with PAH in relation to simultaneously measured invasive reference measures.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We prospectively recruited children undergoing a clinically indicated cardiac catheterization for evaluation of PAH and pulmonary vasoreactivity testing. Echocardiography was performed simultaneously with invasive reference measurements by high-fidelity micromanometer catheter. For analysis, patients were divided into shunt and nonshunt groups. Sixteen children were studied. In the group as a whole, significant correlations were found among \u03c4 and tricuspid deceleration time,\n              <jats:italic>E\u2032<\/jats:italic>\n              ,\n              <jats:italic>E\/E\u2032<\/jats:italic>\n              , Time\n              <jats:sub>\n                <jats:italic>E<\/jats:italic>\n                \u2013\n                <jats:italic>E<\/jats:italic>\n              <\/jats:sub>\n              <jats:italic>\u2032<\/jats:italic>\n              , A wave velocity, and global early and late diastolic strain rate. d\n              <jats:italic>p<\/jats:italic>\n              \/d\n              <jats:italic>t<\/jats:italic>\n              minimum correlated significantly with late diastolic tricuspid annular velocity (\n              <jats:italic>A\u2032<\/jats:italic>\n              ), tissue Doppler imaging\u2013derived systolic:diastolic duration ratio, and global late diastolic strain rate. End-diastolic pressure correlated significantly with tissue Doppler imaging\u2013derived systolic:diastolic duration ratio. On multivariate analysis, tricuspid deceleration time, Time\n              <jats:sub>\n                <jats:italic>E<\/jats:italic>\n                \u2013\n                <jats:italic>E<\/jats:italic>\n              <\/jats:sub>\n              <jats:italic>\u2032<\/jats:italic>\n              , and global early diastolic strain rate were independent predictors of \u03c4, whereas tissue Doppler imaging\u2013derived systolic:diastolic duration ratio was an independent predictor of d\n              <jats:italic>p<\/jats:italic>\n              \/d\n              <jats:italic>t<\/jats:italic>\n              minimum. In general, correlations between echocardiographic and invasive parameters were better in the shunt group than in the nonshunt group.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Echocardiography correlates with invasive reference measures of right ventricular diastolic function in children with PAH, although it does not differentiate between early versus late diastolic abnormalities. Newer echocardiographic techniques may have added value to assess right ventricular diastolic dysfunction in this population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.113.001071","type":"journal-article","created":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T04:48:10Z","timestamp":1393562890000},"page":"491-501","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":56,"title":["Right Ventricular Diastolic Performance in Children With Pulmonary Arterial Hypertension Associated With Congenital Heart Disease"],"prefix":"10.1161","volume":"7","author":[{"given":"Kenichi","family":"Okumura","sequence":"first","affiliation":[{"name":"From the Division of Cardiology, The Labatt Family Heart Center, Hospital for Sick Children, University of Toronto, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Slorach","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, The Labatt Family Heart Center, Hospital for Sick Children, University of Toronto, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Mroczek","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, The Labatt Family Heart Center, Hospital for Sick Children, University of Toronto, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Dragulescu","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, The Labatt Family Heart Center, Hospital for Sick Children, University of Toronto, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Mertens","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, The Labatt Family Heart Center, Hospital for Sick Children, University of Toronto, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N.","family":"Redington","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, The Labatt Family Heart Center, Hospital for Sick Children, University of Toronto, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K.","family":"Friedberg","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, The Labatt Family Heart Center, Hospital for Sick Children, University of Toronto, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00782.2001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/15.suppl_D.2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-0620(98)80049-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.68.7.16"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-5-343"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.03.090"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.02.027"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circimaging.112.000175"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20051"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2007.01370.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.6.1393"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.04.027"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00595-0"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.844340"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.06.005"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00056110"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.679654"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.16.1606"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.05.010"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2010.01277.x"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.03.048"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(96)90476-9"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-008-9215-2"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-11-0703"},{"key":"e_1_3_3_26_2","first-page":"389","article-title":"Diastolic dysfunction.","volume":"12","author":"Tardif JC","year":"1996","unstructured":"Tardif JC, Rouleau JL. 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