{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:53:57Z","timestamp":1787018037018,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>Our purpose was to test the following hypotheses: (1) patients with hypoplastic left heart syndrome who develop significant tricuspid regurgitation (TR) or require tricuspid valve (TV) surgery in the medium term have detectable TV abnormalities by 3-dimensional echocardiography (3DE) prestage 1 palliation and (2) TR is associated with reduced survival and increased TV intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>\n                      Infants were prospectively studied with 3DE and 2DE prestage 1 and followed up for the end points of TR, TV surgery, transplantation, or death. From prestage 1 3DE, spatial coordinates of TV annulus and leaflets were extracted; annulus size, leaflet area, prolapse volume, tethering volume, bending angle, and papillary muscle angle were measured. TR was assessed prestage 1 and at latest follow-up. Of 70 patients, 62 (88.6%) had mild or less TR and 8 (11.4%) had moderate or greater TR prestage 1. Prestage 1 tethering volume correlated to leaflet area (\n                      <jats:italic>r<\/jats:italic>\n                      =0.736;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), annulus area (\n                      <jats:italic>r<\/jats:italic>\n                      =0.651;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), right ventricular end-diastolic area (\n                      <jats:italic>r<\/jats:italic>\n                      =0.347;\n                      <jats:italic>P<\/jats:italic>\n                      =0.003), fractional area change (\n                      <jats:italic>r<\/jats:italic>\n                      =\u22120.387;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), and TR grade (\n                      <jats:italic>r<\/jats:italic>\n                      =0.447;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). At follow-up, 46 (65.7%) had mild or less TR (group A) and 24 (34.3%) had moderate or greater TR (group B). Prestage 1 3DE showed greater TV tethering volume and flatter annulus in group B. Survival was better in group A.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Increased TV tethering volume and flatter bending angle prestage 1 palliation is associated with TV failure at medium-term follow-up. Increased prestage 1 tethering is related to having larger TV annulus, larger leaflet area, larger right ventricular size, and reduced systolic function. TR progression results in increased TV intervention and decreased survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circimaging.113.001161","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T23:11:22Z","timestamp":1406675482000},"page":"765-772","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":60,"title":["Tricuspid Regurgitation in Hypoplastic Left Heart Syndrome"],"prefix":"10.1161","volume":"7","author":[{"given":"Shelby","family":"Kutty","sequence":"first","affiliation":[{"name":"From Pediatric Cardiology, Children\u2019s Hospital and Medical Center and University of Nebraska Medical Center, Omaha (S.K., L.L., A.P., D.A.D.); Stollery Children\u2019s Hospital (T.C., E.T., C.V., D.T.T., J.F.S., N.S.K.) and Department of Biomedical Engineering (R.B.T.), University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Colen","sequence":"additional","affiliation":[{"name":"From Pediatric Cardiology, Children\u2019s Hospital and Medical Center and University of Nebraska Medical Center, Omaha (S.K., L.L., A.P., D.A.D.); Stollery Children\u2019s Hospital (T.C., E.T., C.V., D.T.T., J.F.S., N.S.K.) and Department of Biomedical Engineering (R.B.T.), University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Thompson","sequence":"additional","affiliation":[{"name":"From Pediatric Cardiology, Children\u2019s Hospital and Medical Center and University of Nebraska Medical Center, Omaha (S.K., L.L., A.P., D.A.D.); Stollery Children\u2019s Hospital (T.C., E.T., C.V., D.T.T., J.F.S., N.S.K.) and Department of Biomedical Engineering (R.B.T.), University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edythe","family":"Tham","sequence":"additional","affiliation":[{"name":"From Pediatric Cardiology, Children\u2019s Hospital and Medical Center and University of Nebraska Medical Center, Omaha (S.K., L.L., A.P., D.A.D.); Stollery Children\u2019s Hospital (T.C., E.T., C.V., D.T.T., J.F.S., N.S.K.) and Department of Biomedical Engineering (R.B.T.), University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"From Pediatric Cardiology, Children\u2019s Hospital and Medical Center and University of Nebraska Medical Center, Omaha (S.K., L.L., A.P., D.A.D.); Stollery Children\u2019s Hospital (T.C., E.T., C.V., D.T.T., J.F.S., N.S.K.) and Department of Biomedical Engineering (R.B.T.), University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chodchanok","family":"Vijarnsorn","sequence":"additional","affiliation":[{"name":"From Pediatric Cardiology, Children\u2019s Hospital and Medical Center and University of Nebraska Medical Center, Omaha (S.K., L.L., A.P., D.A.D.); Stollery Children\u2019s Hospital (T.C., E.T., C.V., D.T.T., J.F.S., N.S.K.) and Department of Biomedical Engineering (R.B.T.), University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Polak","sequence":"additional","affiliation":[{"name":"From Pediatric Cardiology, Children\u2019s Hospital and Medical Center and University of Nebraska Medical Center, Omaha (S.K., L.L., A.P., D.A.D.); Stollery Children\u2019s Hospital (T.C., E.T., C.V., D.T.T., J.F.S., N.S.K.) and Department of Biomedical Engineering (R.B.T.), University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongngan T.","family":"Truong","sequence":"additional","affiliation":[{"name":"From Pediatric Cardiology, Children\u2019s Hospital and Medical Center and University of Nebraska Medical Center, Omaha (S.K., L.L., A.P., D.A.D.); Stollery Children\u2019s Hospital (T.C., E.T., C.V., D.T.T., J.F.S., N.S.K.) and Department of Biomedical Engineering (R.B.T.), University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Danford","sequence":"additional","affiliation":[{"name":"From Pediatric Cardiology, Children\u2019s Hospital and Medical Center and University of Nebraska Medical Center, Omaha (S.K., L.L., A.P., D.A.D.); Stollery Children\u2019s Hospital (T.C., E.T., C.V., D.T.T., J.F.S., N.S.K.) and Department of Biomedical Engineering (R.B.T.), University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey F.","family":"Smallhorn","sequence":"additional","affiliation":[{"name":"From Pediatric Cardiology, Children\u2019s Hospital and Medical Center and University of Nebraska Medical Center, Omaha (S.K., L.L., A.P., D.A.D.); Stollery Children\u2019s Hospital (T.C., E.T., C.V., D.T.T., J.F.S., N.S.K.) and Department of Biomedical Engineering (R.B.T.), University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nee Scze","family":"Khoo","sequence":"additional","affiliation":[{"name":"From Pediatric Cardiology, Children\u2019s Hospital and Medical Center and University of Nebraska Medical Center, Omaha (S.K., L.L., A.P., D.A.D.); Stollery Children\u2019s Hospital (T.C., E.T., C.V., D.T.T., J.F.S., N.S.K.) and Department of Biomedical Engineering (R.B.T.), University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(88)90744-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.07.052"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.05.020"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.809566"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jes123"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32834aa56a"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.06.002"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.04.017"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-007-9210-3"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jep044"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.08.011"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.10.047"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.06.005"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.10.997"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.02.008"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.016"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)02795-3"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(00)00495-4"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.025"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000025426.39426.83"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000156449.49998.51"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.07.027"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.04.001"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.846782"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.844019"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.749440"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.6.1826"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.10.066"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(97)00184-X"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.11.065"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.10.040"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.08.012"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.113.001161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:52:52Z","timestamp":1715554372000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.113.001161"}},"subtitle":["Mechanistic Insights From 3-Dimensional Echocardiography and Relationship With Outcomes"],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1161\/CIRCIMAGING.113.001161"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.113.001161","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"2013-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-07-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-07-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}